PRMT8 and SERBP1

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		PRMT8	SERBP1
Gene Name		protein arginine methyltransferase 8	SERPINE1 mRNA binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane	Nucleus Cytoplasm Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Histone-arginine N-methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Identical Protein Binding Protein Homodimerization Activity Histone Methyltransferase Activity (H4-R3 Specific) Protein Heterodimerization Activity	MRNA 3'-UTR Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone Arginine Methylation Regulation Of Protein Binding Histone H4-R3 Methylation	Regulation Of Apoptotic Process Regulation Of MRNA Stability
Pathways
Drugs
Diseases
GWAS		HDL cholesterol ( 19060911)	Crohn's disease ( 22412388)
Protein-Protein Interactions		13 interactors: CEP162 COIL DCAF8 GPATCH2L HIST1H4A OFCC1 PPARA PRMT1 SERBP1 SYNCRIP TAF15 VHL ZNF451	20 interactors: APP CHD3 CSNK2A1 DAXX FBXO25 FXYD3 ITFG1 KAT2B PCAP PIAS1 PIAS3 PIAS4 PRMT8 TDG TERT TOPORS UBA2 UPF2 VAV2 VIM
Entrez ID		56341	26135
HPRD ID		11029	09570
Ensembl ID		ENSG00000111218	ENSG00000142864
Uniprot IDs		Q59GT2 Q9NR22	Q5VU21 Q63HR1 Q8NC51
PDB IDs			3J3A
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Megakaryocyte Differentiation Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Gene Expression Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Negative Regulation Of Myeloid Cell Differentiation Posttranscriptional Regulation Of Gene Expression Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H4-K20 Demethylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Chromatin Modification CRD-mediated MRNA Stabilization Transcription Initiation From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of Myeloid Cell Differentiation Negative Regulation Of Receptor Biosynthetic Process Chromatin Organization Behavioral Response To Nicotine Enamel Mineralization Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Sequestering Of Triglyceride Negative Regulation Of Cholesterol Storage Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription DNA-templated Transcription, Initiation Negative Regulation Of Glycolytic Process DNA Replication-dependent Nucleosome Assembly Regulation Of RNA Biosynthetic Process Negative Regulation Of Appetite Tooth Mineralization Regulation Of RNA Metabolic Process Positive Regulation Of Fatty Acid Beta-oxidation Peptidyl-arginine N-methylation DNA Methylation On Cytosine Histone H4-R3 Methylation Cellular Protein Modification Process Response To Hypoxia Amelogenesis Negative Regulation Of Transcription Regulatory Region DNA Binding Chromatin Silencing At RDNA Negative Regulation Of Macrophage Derived Foam Cell Differentiation	Protein Sumoylation Peptidyl-lysine Modification Positive Regulation Of Protein Sumoylation RNA Metabolic Process Regulation Of Gene Expression Regulation Of Protein Sumoylation Positive Regulation Of Metabolic Process Gene Expression Regulation Of Metabolic Process RNA Biosynthetic Process Peptidyl-amino Acid Modification Chromatin Modification Protein Modification By Small Protein Conjugation Chromatin Organization Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Modification Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Apoptotic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Chromosome Organization Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Cell Death Death Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Protein Binding Positive Regulation Of Cellular Metabolic Process Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Process Cellular Metabolic Process Regulation Of Cell Death Negative Regulation Of Production Of SiRNA Involved In RNA Interference
Tagcloud ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt6 prmt7 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	9q altered cgi contexts experimentally explain familiar functionally give habp4 haplotype hek293t identity inducer insights ki knockdown link microchip overexpression paralogs prompting qrt shared similarity sirna thapsigargin transcriptome tumorigenic
Tagcloud (Difference) ?		bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt1 prmt2 prmt3 prmt4 prmt5 prmt6 prmt7 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized	9q altered cgi contexts experimentally explain familiar functionally give habp4 haplotype hek293t identity inducer insights ki knockdown link microchip overexpression paralogs prompting qrt shared similarity sirna thapsigargin transcriptome tumorigenic
Tagcloud (Intersection) ?