PARD3 and TIAM2

Number of citations of the paper that reports this interaction (PMID 15723051)
93

Data Source:
HPRD (in vivo, in vitro)

		PARD3	TIAM2
Gene Name		par-3 family cell polarity regulator	T-cell lymphoma invasion and metastasis 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Cytosol Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Tight Junction Cell Cortex Endomembrane System Cell Junction Internode Region Of Axon Neuronal Cell Body Protein Complex Axonal Growth Cone Apical Part Of Cell	Cytosol Membrane Lamellipodium Filopodium Growth Cone Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase C Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding	Receptor Signaling Protein Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity
	Biological Process	Microtubule Cytoskeleton Organization Apical Constriction Protein Complex Assembly Protein Targeting To Membrane Cell Cycle Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Axonogenesis Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Positive Regulation Of Myelination Regulation Of Actin Filament-based Process Cell Junction Assembly Wound Healing, Spreading Of Cells Cell-cell Junction Organization Centrosome Localization Regulation Of Cellular Localization Tight Junction Assembly Establishment Of Epithelial Cell Polarity	Small GTPase Mediated Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer Cell junction organization TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Tight junction interactions Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Cell-cell junction organization Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer	Rho GTPase cycle PPARA activates gene expression Signaling by GPCR GPCR downstream signaling Signalling by NGF Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 19684603) Emphysema-related traits ( 20709820) Major depressive disorder ( 21621269) Schizophrenia ( 21682944)
Protein-Protein Interactions		27 interactors: CDC42 DYNLL1 F11R INADL INSC LIMK2 PARD6A PARD6B PARD6G PLCB1 PLCB3 PNMA1 PRKCG PRKCI PVRL1 PVRL3 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 YWHAB YWHAG YWHAH YWHAZ	9 interactors: ANXA7 DISC1 DNM2 H2AFX PARD3 SH3GL2 TK1 TNIK UFD1L
Entrez ID		56288	26230
HPRD ID		05994	05273
Ensembl ID		ENSG00000148498	ENSG00000146426
Uniprot IDs		Q8TEW0	B3KW11 E9PKT1 Q8IVF5
PDB IDs		2KOM
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Organization Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cell Junction Assembly Cellular Response To Growth Factor Stimulus Cellular Component Assembly Tight Junction Assembly Positive Regulation Of Apoptotic Process Response To Growth Factor Regulation Of Cellular Component Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Apical Junction Assembly Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Signal Transduction Cellular Response To Organic Substance Regulation Of Cell Death Positive Regulation Of Transport Cell-cell Junction Assembly Signaling Positive Regulation Of Mitochondrion Organization Cell Communication Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Development Regulation Of Intracellular Transport Regulation Of Apoptotic Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation System Development Regulation Of Establishment Of Protein Localization Nervous System Development Regulation Of Cell Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Anatomical Structure Development Regulation Of Signal Transduction Response To Transforming Growth Factor Beta Positive Regulation Of Signal Transduction Intrinsic Apoptotic Signaling Pathway SMAD Protein Complex Assembly Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cellular Localization Response To Organic Substance Regulation Of Protein Localization Multicellular Organismal Development	Membrane Organization Anatomical Structure Development Developmental Process Generation Of Neurons System Development Neurogenesis Multicellular Organismal Development Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Fetal Process Involved In Parturition Organelle Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Cell Differentiation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cell Projection Organization Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Nervous System Development Synaptic Vesicle Transport Negative Regulation Of Membrane Tubulation Skeletal Muscle Cell Proliferation Regulation Of Neuron Differentiation Cellular Localization Response To Stimulus Neuron Projection Morphogenesis Regulation Of Neurogenesis Cell Proliferation Response To Cortisol Apical Constriction Thymidine Metabolic Process Asymmetric Cell Division Establishment Of Vesicle Localization Vesicle Localization Deoxyribonucleoside Monophosphate Biosynthetic Process Neuron Projection Development Cell Projection Morphogenesis Antigen Processing And Presentation Of Peptide Antigen Regulation Of Cell Development Cell Part Morphogenesis Activation Of JNKK Activity Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Cellular Component Assembly Protein Localization Positive Regulation Of Myelination Golgi Vesicle Transport Neuron Development Wnt Signaling Pathway
Tagcloud ?		antisaccade assayed blink disrupt eeg electrodermal endophenotype endophenotypes exome exonic eye illumina kernel maf mapped movements neutral nonsynonymous pleasant pnpla7 polymorphic psychophysiological rare resting snp snps startle technologies theta
Tagcloud (Difference) ?		antisaccade assayed blink disrupt eeg electrodermal endophenotype endophenotypes exome exonic eye illumina kernel maf mapped movements neutral nonsynonymous pleasant pnpla7 polymorphic psychophysiological rare resting snp snps startle technologies theta
Tagcloud (Intersection) ?