TIAM2

Gene Name		T-cell lymphoma invasion and metastasis 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Lamellipodium Filopodium Growth Cone Extracellular Vesicular Exosome
	Molecular Function	Receptor Signaling Protein Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Rho GTPase cycle PPARA activates gene expression Signaling by GPCR GPCR downstream signaling Signalling by NGF Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-protein Interactions		9 interactors: ANXA7 DISC1 DNM2 H2AFX PARD3 SH3GL2 TK1 TNIK UFD1L
Entrez ID		26230
HPRD ID		05273
Ensembl ID		ENSG00000146426
Uniprot IDs		B3KW11 E9PKT1 Q8IVF5
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Organization Anatomical Structure Development Developmental Process Generation Of Neurons System Development Neurogenesis Multicellular Organismal Development Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Fetal Process Involved In Parturition Organelle Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Cell Differentiation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cell Projection Organization Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Nervous System Development Synaptic Vesicle Transport Negative Regulation Of Membrane Tubulation Skeletal Muscle Cell Proliferation Regulation Of Neuron Differentiation Cellular Localization Response To Stimulus Neuron Projection Morphogenesis Regulation Of Neurogenesis Cell Proliferation Response To Cortisol Apical Constriction Thymidine Metabolic Process Asymmetric Cell Division Establishment Of Vesicle Localization Vesicle Localization Deoxyribonucleoside Monophosphate Biosynthetic Process Neuron Projection Development Cell Projection Morphogenesis Antigen Processing And Presentation Of Peptide Antigen Regulation Of Cell Development Cell Part Morphogenesis Activation Of JNKK Activity Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Cellular Component Assembly Protein Localization Positive Regulation Of Myelination Golgi Vesicle Transport Neuron Development Wnt Signaling Pathway
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