ENAH and WAS

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
HPRD (in vitro, in vivo)

		ENAH	WAS
Gene Name		enabled homolog (Drosophila)	Wiskott-Aldrich syndrome
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Plasma Membrane Focal Adhesion Lamellipodium Cell Junction Filopodium Synapse	Cytosol Cell-cell Junction Vesicle Membrane Actin Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding SH3 Domain Binding WW Domain Binding	Actin Binding Small GTPase Regulator Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Identical Protein Binding Phospholipase Binding
	Biological Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Intracellular Transport T Cell Receptor Signaling Pathway	Protein Complex Assembly Defense Response Immune Response Blood Coagulation Actin Polymerization Or Depolymerization Epidermis Development Endosomal Transport Actin Filament Polymerization Actin Filament-based Movement Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Innate Immune Response Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		TCR signaling Generation of second messenger molecules Axon guidance Signaling by Robo receptor Adaptive Immune System	TCR signaling Generation of second messenger molecules Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		20 interactors: ABI1 ABI2 ABI3 ABL1 APBB1 BAIAP2 DNMBP FAT1 FYB GPHN MAPK1 PFN1 PRPF40A ROBO4 SPTA1 TERF2IP TES WAS XIRP1 ZYX	53 interactors: ABI3 ACTC1 APBB1 APPBP2 ARHGAP1 ARHGEF7 ARPC1B ARPC2 ARPC3 BAIAP2L1 BTK C5AR1 CDC42 CIB1 CRKL CSNK2A1 CSNK2A2 DLG1 ENAH EVL FCHSD2 FGR FYB FYN GAS7 GRB2 HCK HCLS1 ITK ITSN2 LCK LCP2 NCK1 NCK2 NCKIPSD PIK3R1 PLCG1 PRPF40A PSTPIP1 PTPN12 RAC1 RGS14 RHOJ SORBS2 SRC TCERG1 TEC TNK2 TRIP10 VASP WBP4 WIPF1 WIPF2
Entrez ID		55740	7454
HPRD ID		12360	02314
Ensembl ID		ENSG00000154380	ENSG00000015285
Uniprot IDs		Q8N8S7	P42768
PDB IDs		2HO2 2IYB 2XQN	1CEE 1EJ5 1T84 2A3Z 2K42 2OT0
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Cytoskeleton Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of Cytoskeleton Organization Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Immune Response-regulating Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Anatomical Structure Morphogenesis Positive Regulation Of Immune Response Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Anatomical Structure Development Cell Projection Organization Actin Polymerization Or Depolymerization Neuron Projection Development Locomotion Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Immune Response Regulation Of Immune System Process Cell Development Axonogenesis Developmental Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Development Neuron Development Cell Morphogenesis Involved In Neuron Differentiation T Cell Receptor Signaling Pathway Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Cell Motility Neuron Projection Morphogenesis System Development Regulation Of Response To DNA Damage Stimulus Cell Morphogenesis Endocytosis Regulation Of Actin Nucleation	Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Immune System Process Locomotion Axon Guidance Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Actin Filament Organization Innate Immune Response Chemotaxis Positive Regulation Of Actin Filament Polymerization Axonogenesis Neuron Projection Morphogenesis Immune Response Positive Regulation Of Protein Polymerization Enzyme Linked Receptor Protein Signaling Pathway Axon Development Actin Cytoskeleton Organization Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Positive Regulation Of Protein Complex Assembly Cell Morphogenesis Involved In Differentiation Cytoskeleton Organization Actin Filament-based Process Regulation Of Actin Filament Polymerization Cell Surface Receptor Signaling Pathway Endocytosis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Protein Complex Assembly Regulation Of Actin Filament Length Neuron Projection Development Regulation Of Cellular Component Organization Antigen Receptor-mediated Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis Response To External Stimulus Signal Transduction T Cell Receptor Signaling Pathway Signaling
Tagcloud ?		atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable eventually icoslg identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation
Tagcloud (Difference) ?		atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable eventually icoslg identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation
Tagcloud (Intersection) ?