ENAH and ROBO4

Number of citations of the paper that reports this interaction (PMID 12941633)
67

Data Source:
HPRD (in vitro)

		ENAH	ROBO4
Gene Name		enabled homolog (Drosophila)	roundabout, axon guidance receptor, homolog 4 (Drosophila)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Plasma Membrane Focal Adhesion Lamellipodium Cell Junction Filopodium Synapse	External Side Of Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Protein Binding SH3 Domain Binding WW Domain Binding	Receptor Activity
	Biological Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Intracellular Transport T Cell Receptor Signaling Pathway	Angiogenesis Cell Differentiation Regulation Of Cell Migration Negative Regulation Of Cell Migration
Pathways		TCR signaling Generation of second messenger molecules Axon guidance Signaling by Robo receptor Adaptive Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		20 interactors: ABI1 ABI2 ABI3 ABL1 APBB1 BAIAP2 DNMBP FAT1 FYB GPHN MAPK1 PFN1 PRPF40A ROBO4 SPTA1 TERF2IP TES WAS XIRP1 ZYX	4 interactors: ENAH PPARG RXRA THRB
Entrez ID		55740	54538
HPRD ID		12360	09604
Ensembl ID		ENSG00000154380	ENSG00000154133
Uniprot IDs		Q8N8S7	B4DYV8 Q8WZ75
PDB IDs		2HO2 2IYB 2XQN
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Cytoskeleton Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of Cytoskeleton Organization Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Immune Response-regulating Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Anatomical Structure Morphogenesis Positive Regulation Of Immune Response Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Anatomical Structure Development Cell Projection Organization Actin Polymerization Or Depolymerization Neuron Projection Development Locomotion Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Immune Response Regulation Of Immune System Process Cell Development Axonogenesis Developmental Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Development Neuron Development Cell Morphogenesis Involved In Neuron Differentiation T Cell Receptor Signaling Pathway Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Cell Motility Neuron Projection Morphogenesis System Development Regulation Of Response To DNA Damage Stimulus Cell Morphogenesis Endocytosis Regulation Of Actin Nucleation	Peroxisome Proliferator Activated Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Epithelium Development Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Tissue Development Response To Steroid Hormone Epithelial Cell Differentiation Cellular Response To Hormone Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Retinoic Acid Response To Metformin Response To Diuretic Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Pancreatic Stellate Cell Proliferation Response To Lipid Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Response To Hormone Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Vitamin E Positive Regulation Of Translational Initiation By Iron Regulation Of Cholesterol Transporter Activity Negative Regulation Of Transcription, DNA-templated Placenta Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cell Differentiation Negative Regulation Of Female Receptivity Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Reproductive Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process System Development Positive Regulation Of Gene Expression Cellular Response To Hyperoxia Receptor Biosynthetic Process Female Courtship Behavior Negative Regulation Of Multicellular Organismal Metabolic Process Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable eventually icoslg identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation	adaptation antiangiogenic attenuation coordinated demethylase drive dysregulation embryonal g9a germ h3k9 hallmark hypoxia igfbp4 instrumental jmjd1a mutually notch4 offering opposing opposition played renewal sac seminomas striking tfpi whereby yolk
Tagcloud (Difference) ?		atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable eventually icoslg identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation	adaptation antiangiogenic attenuation coordinated demethylase drive dysregulation embryonal g9a germ h3k9 hallmark hypoxia igfbp4 instrumental jmjd1a mutually notch4 offering opposing opposition played renewal sac seminomas striking tfpi whereby yolk
Tagcloud (Intersection) ?