ENAH and XIRP1

Number of citations of the paper that reports this interaction (PMID 16631741)
16

Data Source:
BioGRID (two hybrid)

		ENAH	XIRP1
Gene Name		enabled homolog (Drosophila)	xin actin-binding repeat containing 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Plasma Membrane Focal Adhesion Lamellipodium Cell Junction Filopodium Synapse	Fascia Adherens
	Molecular Function	Actin Binding Protein Binding SH3 Domain Binding WW Domain Binding	Actin Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Intracellular Transport T Cell Receptor Signaling Pathway	Negative Regulation Of Cell Proliferation Regulation Of Membrane Potential Sarcomere Organization Cardiac Muscle Cell Development
Pathways		TCR signaling Generation of second messenger molecules Axon guidance Signaling by Robo receptor Adaptive Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		20 interactors: ABI1 ABI2 ABI3 ABL1 APBB1 BAIAP2 DNMBP FAT1 FYB GPHN MAPK1 PFN1 PRPF40A ROBO4 SPTA1 TERF2IP TES WAS XIRP1 ZYX	7 interactors: ACTA1 ENAH EVL FLNC NEB NEBL VASP
Entrez ID		55740	165904
HPRD ID		12360	16727
Ensembl ID		ENSG00000154380	ENSG00000168334
Uniprot IDs		Q8N8S7	Q702N8
PDB IDs		2HO2 2IYB 2XQN
Enriched GO Terms of Interacting Partners?		Actin Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Cytoskeleton Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of Cytoskeleton Organization Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Cellular Component Organization Immune Response-regulating Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Anatomical Structure Morphogenesis Positive Regulation Of Immune Response Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Actin Nucleation Anatomical Structure Development Cell Projection Organization Actin Polymerization Or Depolymerization Neuron Projection Development Locomotion Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Immune Response Regulation Of Immune System Process Cell Development Axonogenesis Developmental Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Development Neuron Development Cell Morphogenesis Involved In Neuron Differentiation T Cell Receptor Signaling Pathway Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Cell Motility Neuron Projection Morphogenesis System Development Regulation Of Response To DNA Damage Stimulus Cell Morphogenesis Endocytosis Regulation Of Actin Nucleation	Actin Filament-based Process Actin Filament Organization Actin Cytoskeleton Organization Cell Development Actin Polymerization Or Depolymerization Cytoskeleton Organization Muscle Structure Development Striated Muscle Cell Development Muscle Cell Development Anatomical Structure Development Movement Of Cell Or Subcellular Component Regulation Of Actin Filament Length Striated Muscle Cell Differentiation Muscle Filament Sliding Actin-myosin Filament Sliding Developmental Process Cell Differentiation Cellular Component Assembly Actin-mediated Cell Contraction Muscle Cell Differentiation Regulation Of Cellular Component Size Muscle Fiber Development Regulation Of Actin Cytoskeleton Organization Anatomical Structure Formation Involved In Morphogenesis Actin Filament-based Movement Axon Guidance Protein Homotetramerization Regulation Of Actin Filament-based Process System Development Anatomical Structure Morphogenesis Myofibril Assembly Cardiac Muscle Thin Filament Assembly Regulation Of Cytoskeleton Organization Axonogenesis Multicellular Organismal Development Protein Tetramerization Neural Tube Closure Positive Regulation Of Actin Filament Polymerization T Cell Receptor Signaling Pathway Axon Development Actomyosin Structure Organization Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Protein Polymerization Chemotaxis Skeletal Muscle Fiber Adaptation Neural Tube Formation Neuron Projection Morphogenesis Organelle Organization Antigen Receptor-mediated Signaling Pathway Embryonic Epithelial Tube Formation
Tagcloud ?		atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable eventually icoslg identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation	0x 1x adamts13 aspm atp6v0a2 bioinformatic bl chickens col12a1 fowl grm5 interpretations jungle lrp2 obscn plau ppp1ca prkdc resequencing rnf168 sanger sl slv smyth stab2 ubc ubiquitinylation vitiliginous vitiligo
Tagcloud (Difference) ?		atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable eventually icoslg identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation	0x 1x adamts13 aspm atp6v0a2 bioinformatic bl chickens col12a1 fowl grm5 interpretations jungle lrp2 obscn plau ppp1ca prkdc resequencing rnf168 sanger sl slv smyth stab2 ubc ubiquitinylation vitiliginous vitiligo
Tagcloud (Intersection) ?