RASIP1 and RAP2A

Number of citations of the paper that reports this interaction (PMID 15031288)
17

Data Source:
HPRD (two hybrid)

		RASIP1	RAP2A
Gene Name		Ras interacting protein 1	RAP2A, member of RAS oncogene family
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Stack Perinuclear Region Of Cytoplasm	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function		GTPase Activity Protein Binding GTP Binding
	Biological Process	Angiogenesis Vasculogenesis Signal Transduction Negative Regulation Of Autophagy Regulation Of Rho GTPase Activity Branching Morphogenesis Of An Epithelial Tube	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Cellular Response To Drug Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane
Pathways
Drugs			Guanosine-5\'-Triphosphate Guanosine-5\'-Diphosphate
Diseases
GWAS		Bipolar disorder ( 21926972) Crohn's disease ( 21102463) Dietary macronutrient intake ( 23372041) Retinal vascular caliber ( 21060863)
Protein-Protein Interactions		8 interactors: ARFGAP1 HRAS LDB2 MRAS RAP1A RAP2A RRAS RRAS2	32 interactors: ACVR1 ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 MLLT4 NEDD4 PLG RAF1 RALA RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK
Entrez ID		54922	5911
HPRD ID		15214	01547
Ensembl ID		ENSG00000105538
Uniprot IDs		Q5U651 Q7L251 Q8IUR2	P10114
PDB IDs			1KAO 2RAP 3RAP
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Rap Protein Signal Transduction Intracellular Signal Transduction Regulation Of Cell Migration Regulation Of Phosphorylation Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Movement Positive Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Signal Transduction Cell Differentiation Activation Of MAPKK Activity Developmental Process Regulation Of Protein Phosphorylation Signaling Positive Regulation Of Cellular Protein Metabolic Process Cell Communication Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Projection Organization Positive Regulation Of Kinase Activity Regulation Of Ras GTPase Activity System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Cellular Response To Stimulus Positive Regulation Of ERK1 And ERK2 Cascade Actin Cytoskeleton Organization Regulation Of Signal Transduction Actin Filament-based Process Generation Of Neurons Regulation Of Ras Protein Signal Transduction Regulation Of Cell Differentiation Multicellular Organismal Development Neurogenesis Regulation Of JNK Cascade Positive Regulation Of GTPase Activity Anatomical Structure Development Regulation Of Signaling Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Regulation Of Stress-activated MAPK Cascade	Intracellular Signal Transduction Response To Stimulus Regulation Of Signaling Regulation Of Catalytic Activity Cell Communication Signal Transduction Cellular Response To Stimulus Positive Regulation Of Metabolic Process Positive Regulation Of Rap GTPase Activity Signaling Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rap GTPase Activity Positive Regulation Of Catalytic Activity Regulation Of Rap Protein Signal Transduction Signal Transduction By Phosphorylation Regulation Of Metabolic Process Small GTPase Mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Regulation Of GTPase Activity Wound Healing Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Ras Protein Signal Transduction Regulation Of Dendrite Morphogenesis Response To Wounding Regulation Of Cell Projection Organization Positive Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Platelet Activation Regulation Of Ras GTPase Activity Cellular Response To Growth Factor Stimulus Response To Organic Substance Regulation Of Cellular Process Response To Growth Factor Regulation Of Dendrite Development Cardiovascular System Development Cell Surface Receptor Signaling Pathway Positive Regulation Of Ras GTPase Activity Regulation Of Cell Differentiation Negative Regulation Of Cell Proliferation Cell Activation Regulation Of Cellular Localization Cell Differentiation Blood Vessel Development Response To Stress Vasculature Development Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Activation Of MAPKK Activity
Tagcloud ?			cleave competitors degrades diaminopimelic effectors endopeptidase endopeptidases exploiting extrude heteromeric marcescens meso muropeptides neutralization neutralize orthologues pentapeptides promiscuity rap1a raps serratia ssp1 ssp2 steric tetrapenta tetrapeptides tetratetra tetratetrapeptides tripeptides
Tagcloud (Difference) ?			cleave competitors degrades diaminopimelic effectors endopeptidase endopeptidases exploiting extrude heteromeric marcescens meso muropeptides neutralization neutralize orthologues pentapeptides promiscuity rap1a raps serratia ssp1 ssp2 steric tetrapenta tetrapeptides tetratetra tetratetrapeptides tripeptides
Tagcloud (Intersection) ?