RAP2A and ARHGAP29

Number of citations of the paper that reports this interaction (PMID 15752761)
7

Data Source:
HPRD (two hybrid, in vitro)

		RAP2A	ARHGAP29
Gene Name		RAP2A, member of RAS oncogene family	Rho GTPase activating protein 29
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane Extracellular Vesicular Exosome	Cytosol
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Rho GTPase Activator Activity PDZ Domain Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Cellular Response To Drug Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Rho GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways			Rho GTPase cycle Signaling by Rho GTPases
Drugs		Guanosine-5\'-Triphosphate Guanosine-5\'-Diphosphate
Diseases
GWAS			D-dimer levels ( 21502573)
Protein-Protein Interactions		32 interactors: ACVR1 ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 MLLT4 NEDD4 PLG RAF1 RALA RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK	7 interactors: AKT1 CDC42 KDM1A MAGEA11 PTPN13 RAP2A RHOD
Entrez ID		5911	9411
HPRD ID		01547	06674
Ensembl ID
Uniprot IDs		P10114	Q52LW3
PDB IDs		1KAO 2RAP 3RAP
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Response To Stimulus Regulation Of Signaling Regulation Of Catalytic Activity Cell Communication Signal Transduction Cellular Response To Stimulus Positive Regulation Of Metabolic Process Positive Regulation Of Rap GTPase Activity Signaling Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rap GTPase Activity Positive Regulation Of Catalytic Activity Regulation Of Rap Protein Signal Transduction Signal Transduction By Phosphorylation Regulation Of Metabolic Process Small GTPase Mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Regulation Of GTPase Activity Wound Healing Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Ras Protein Signal Transduction Regulation Of Dendrite Morphogenesis Response To Wounding Regulation Of Cell Projection Organization Positive Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Platelet Activation Regulation Of Ras GTPase Activity Cellular Response To Growth Factor Stimulus Response To Organic Substance Regulation Of Cellular Process Response To Growth Factor Regulation Of Dendrite Development Cardiovascular System Development Cell Surface Receptor Signaling Pathway Positive Regulation Of Ras GTPase Activity Regulation Of Cell Differentiation Negative Regulation Of Cell Proliferation Cell Activation Regulation Of Cellular Localization Cell Differentiation Blood Vessel Development Response To Stress Vasculature Development Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Activation Of MAPKK Activity	Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Regulation Of Cellular Component Organization Regulation Of Organelle Organization Cell Projection Assembly Muscle Cell Differentiation Positive Regulation Of Cell Adhesion Cell Projection Organization Blood Coagulation Hemostasis Endomembrane System Organization Actin Filament Bundle Assembly Cellular Protein Localization T Cell Costimulation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cell Projection Organization Gland Development Muscle Structure Development Adherens Junction Organization Organelle Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Glycogen Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Primitive Erythrocyte Differentiation Regulation Of Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cell Migration Wound Healing Actin Cytoskeleton Organization Regulation Of MAPK Cascade Small GTPase Mediated Signal Transduction Regulation Of Cell Adhesion Regulation Of Cell Motility Myeloid Leukocyte Differentiation Actin Filament-based Process Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Positive Regulation Of Hair Follicle Cell Proliferation Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Protein Binding Protein Localization Regulation Of Cellular Protein Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		cleave competitors degrades diaminopimelic effectors endopeptidase endopeptidases exploiting extrude heteromeric marcescens meso muropeptides neutralization neutralize orthologues pentapeptides promiscuity rap1a raps serratia ssp1 ssp2 steric tetrapenta tetrapeptides tetratetra tetratetrapeptides tripeptides
Tagcloud (Difference) ?		cleave competitors degrades diaminopimelic effectors endopeptidase endopeptidases exploiting extrude heteromeric marcescens meso muropeptides neutralization neutralize orthologues pentapeptides promiscuity rap1a raps serratia ssp1 ssp2 steric tetrapenta tetrapeptides tetratetra tetratetrapeptides tripeptides
Tagcloud (Intersection) ?