RAP2A and RAPGEF3

Number of citations of the paper that reports this interaction (PMID 10777494)
67

Data Source:
BioGRID (enzymatic study)

		RAP2A	RAPGEF3
Gene Name		RAP2A, member of RAS oncogene family	Rap guanine nucleotide exchange factor (GEF) 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane Extracellular Vesicular Exosome	Plasma Membrane CAMP-dependent Protein Kinase Complex Endomembrane System Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Rap Guanyl-nucleotide Exchange Factor Activity CAMP Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Cellular Response To Drug Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane	Angiogenesis Energy Reserve Metabolic Process Signal Transduction Blood Coagulation Cell Proliferation CAMP-mediated Signaling Platelet Activation Positive Regulation Of CAMP Catabolic Process Rap Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Small Molecule Metabolic Process Positive Regulation Of Angiogenesis Regulation Of Protein Kinase Activity Regulation Of Insulin Secretion Positive Regulation Of Stress Fiber Assembly Establishment Of Endothelial Barrier Cellular Response To CAMP Regulation Of Actin Cytoskeleton Reorganization
Pathways			Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Integration of energy metabolism Regulation of insulin secretion Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) Adaptive Immune System
Drugs		Guanosine-5\'-Triphosphate Guanosine-5\'-Diphosphate
Diseases
GWAS
Protein-Protein Interactions		32 interactors: ACVR1 ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 MLLT4 NEDD4 PLG RAF1 RALA RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK	6 interactors: AP2B1 MAP1A PNMA1 RAP1A RAP2A RRAS2
Entrez ID		5911	10411
HPRD ID		01547	06928
Ensembl ID			ENSG00000079337
Uniprot IDs		P10114	O95398 Q99777
PDB IDs		1KAO 2RAP 3RAP
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Response To Stimulus Regulation Of Signaling Regulation Of Catalytic Activity Cell Communication Signal Transduction Cellular Response To Stimulus Positive Regulation Of Metabolic Process Positive Regulation Of Rap GTPase Activity Signaling Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rap GTPase Activity Positive Regulation Of Catalytic Activity Regulation Of Rap Protein Signal Transduction Signal Transduction By Phosphorylation Regulation Of Metabolic Process Small GTPase Mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Regulation Of GTPase Activity Wound Healing Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Ras Protein Signal Transduction Regulation Of Dendrite Morphogenesis Response To Wounding Regulation Of Cell Projection Organization Positive Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Platelet Activation Regulation Of Ras GTPase Activity Cellular Response To Growth Factor Stimulus Response To Organic Substance Regulation Of Cellular Process Response To Growth Factor Regulation Of Dendrite Development Cardiovascular System Development Cell Surface Receptor Signaling Pathway Positive Regulation Of Ras GTPase Activity Regulation Of Cell Differentiation Negative Regulation Of Cell Proliferation Cell Activation Regulation Of Cellular Localization Cell Differentiation Blood Vessel Development Response To Stress Vasculature Development Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Activation Of MAPKK Activity	Rap Protein Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction
Tagcloud ?		cleave competitors degrades diaminopimelic effectors endopeptidase endopeptidases exploiting extrude heteromeric marcescens meso muropeptides neutralization neutralize orthologues pentapeptides promiscuity rap1a raps serratia ssp1 ssp2 steric tetrapenta tetrapeptides tetratetra tetratetrapeptides tripeptides
Tagcloud (Difference) ?		cleave competitors degrades diaminopimelic effectors endopeptidase endopeptidases exploiting extrude heteromeric marcescens meso muropeptides neutralization neutralize orthologues pentapeptides promiscuity rap1a raps serratia ssp1 ssp2 steric tetrapenta tetrapeptides tetratetra tetratetrapeptides tripeptides
Tagcloud (Intersection) ?