SNRK and STK11

Number of citations of the paper that reports this interaction (PMID 15733851)
39

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro, in vivo)

		SNRK	STK11
Gene Name		SNF related kinase	serine/threonine kinase 11
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Mitochondrion Cytosol Membrane TCR Signalosome Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding	Magnesium Ion Binding P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding LRR Domain Binding Protein Kinase Activator Activity Protein Complex Binding
	Biological Process	Protein Phosphorylation Myeloid Cell Differentiation	Regulation Of Cell Growth Tissue Homeostasis Vasculature Development Energy Reserve Metabolic Process Protein Phosphorylation Autophagy Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Spermatid Development Axonogenesis Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Response To Ionizing Radiation Establishment Of Cell Polarity Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase Activity Response To Glucagon Response To Lipid TCR Signalosome Assembly Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Anoikis Small Molecule Metabolic Process Positive Thymic T Cell Selection Positive Regulation Of Gluconeogenesis Protein Autophosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Protein Heterooligomerization Golgi Localization Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways			Insulin receptor signalling cascade Integration of energy metabolism IRS-mediated signalling Regulation of AMPK activity via LKB1 mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Alzheimer's disease ( 22005930)
Protein-Protein Interactions		3 interactors: HSPA1A JUN STK11	29 interactors: APP ATM CAB39 CDC37 ETV4 MAPRE1 MARK1 MARK2 MARK4 MOB4 PARD3 PRKAA1 PRKAA2 PRKACA PTEN RPS6KA3 RPS6KA5 RPS6KB1 SIK1 SIRT1 SMARCA4 SNRK SPDEF STK11IP STRADA STRADB TNIP2 TP53 UBE2D2
Entrez ID		54861	6794
HPRD ID		18082	03740
Ensembl ID		ENSG00000163788	ENSG00000118046
Uniprot IDs		E7EUC4 Q9NRH2	Q15831
PDB IDs			2WTK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Proliferation Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Immune System Process Response To Abiotic Stimulus Cellular Response To Potassium Ion Starvation TCR Signalosome Assembly Negative Regulation Of Cell Growth Regulation Of Myeloid Cell Differentiation Regulation Of Immune System Process Leading Edge Cell Differentiation Cellular Heat Acclimation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Regulation Of Cell Proliferation Cellular Response To Stress Regulation Of Cell Differentiation Negative Regulation Of Growth Regulation Of Epithelial Cell Proliferation Leukocyte Differentiation Regulation Of Cellular Protein Metabolic Process Apoptotic Signaling Pathway Regulation Of Cell Growth Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Monocyte Differentiation Anoikis Regulation Of Protein Metabolic Process Cellular Response To UV-B Response To Oxidative Stress SMAD Protein Import Into Nucleus Response To Radiation Immune Response-regulating Signaling Pathway Positive Regulation By Host Of Viral Transcription Negative Regulation Of Inclusion Body Assembly Positive Thymic T Cell Selection Response To Organic Substance Leukocyte Activation Negative Regulation By Host Of Viral Transcription Negative Regulation Of Protein Autophosphorylation Vasculature Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Microglial Cell Activation Regulation Of Signal Transduction Axon Development Regulation Of Monocyte Differentiation Golgi Localization Regulation Of Growth Hemopoiesis Response To UV-B Positive Regulation Of Immune Response Regulation Of Inclusion Body Assembly	Regulation Of Cell Cycle Protein Phosphorylation Cell Cycle Cellular Protein Modification Process Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Protein Metabolic Process Cell Cycle Arrest Regulation Of Protein Metabolic Process Intracellular Signal Transduction Regulation Of Cell Death Histone Phosphorylation Regulation Of Mitotic Cell Cycle Cell Cycle Process Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Phosphate-containing Compound Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Histone-serine Phosphorylation Cellular Response To Organic Substance Regulation Of Protein Kinase Activity Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Insulin Receptor Signaling Pathway Protein Metabolic Process Cell Differentiation Signaling Response To Insulin Response To Peptide Hormone Cell Communication Response To External Stimulus Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Peptide Hormone Stimulus Response To Peptide Cellular Response To Peptide Positive Regulation Of Protein Phosphorylation Negative Regulation Of Cell Death Regulation Of Signal Transduction
Tagcloud ?		ablation abundantly activates adipocyte adipocytes adipose aspects attributable biology cultured defective fermenting ikkbeta indication jnk knockdown knocking lipolysis macrophage maintaining mtorc1 obese onefold phosphoproteomic rapamycin repressed sensitizer sucrose summary	alleles atm brca1 brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp suggestive suspicion unlikely venue
Tagcloud (Difference) ?		ablation abundantly activates adipocyte adipocytes adipose aspects attributable biology cultured defective fermenting ikkbeta indication jnk knockdown knocking lipolysis macrophage maintaining mtorc1 obese onefold phosphoproteomic rapamycin repressed sensitizer sucrose summary	alleles atm brca1 brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp suggestive suspicion unlikely venue
Tagcloud (Intersection) ?