P4HTM and PDIA2

Number of citations of the paper that reports this interaction (PMID 12485997)
13

Data Source:
BioGRID (pull down)

		P4HTM	PDIA2
Gene Name		prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	protein disulfide isomerase family A, member 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Iron Ion Binding Calcium Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors L-ascorbic Acid Binding	Protein Disulfide Isomerase Activity Steroid Binding Protein Binding Peptidyl-proline 4-dioxygenase Activity
	Biological Process	Oxidation-reduction Process	Protein Folding Protein Retention In ER Lumen Peptidyl-proline Hydroxylation Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: GLP1R PDIA2 UBC	7 interactors: CALR COL2A1 CUL3 GAPDH P4HTM PPARG SST
Entrez ID		54681	64714
HPRD ID		17842	07617
Ensembl ID		ENSG00000178467	ENSG00000185615
Uniprot IDs		Q9NXG6	Q13087
PDB IDs
Enriched GO Terms of Interacting Partners?		Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Generation Of Precursor Metabolites And Energy Protein Retention In ER Lumen Viral Protein Processing Maintenance Of Protein Localization In Endoplasmic Reticulum Regulation Of Signaling Cellular Homeostasis CAMP-mediated Signaling Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Stress Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Peptidyl-proline Hydroxylation Glycogen Biosynthetic Process Intracellular Transport Of Virus Activation Of Adenylate Cyclase Activity Protein Hydroxylation Cyclic-nucleotide-mediated Signaling Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Glucagon Stimulus Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Lyase Activity Negative Regulation Of ERBB Signaling Pathway Regulation Of Cellular Response To Oxidative Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Response To Glucagon Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Adenylate Cyclase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 9 Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Glycogen Metabolic Process Positive Regulation Of CAMP Biosynthetic Process	Cellular Response To Lithium Ion Response To Lithium Ion Cellular Response To Organic Substance Positive Regulation Of Phagocytosis Apoptotic Process Programmed Cell Death Cell Death Death Negative Regulation Of Signal Transduction Regulation Of Phagocytosis Negative Regulation Of Signaling Response To Organic Substance Response To Steroid Hormone Negative Regulation Of Translation Response To Metformin Low-density Lipoprotein Particle Receptor Biosynthetic Process Peptide Antigen Assembly With MHC Class I Protein Complex Negative Regulation Of Pancreatic Stellate Cell Proliferation Peptidyl-cysteine S-trans-nitrosylation Response To Diuretic Protein Stabilization Response To Drug Heart Development Positive Regulation Of Endocytosis Regulation Of Cell Proliferation Regulation Of DNA Replication Cellular Response To Metal Ion Regulation Of Cholesterol Transporter Activity Cellular Response To Vitamin E Hormone-mediated Signaling Pathway Regulation Of Protein Stability Cellular Response To Inorganic Substance Cell Cycle Arrest Trophectodermal Cellular Morphogenesis Sequestering Of Calcium Ion Regulation Of Endocytosis Negative Regulation Of Cellular Protein Metabolic Process Response To Temperature Stimulus Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Peptidyl-cysteine S-nitrosylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Response To Lipid Cardiovascular System Development Response To Estrogen Response To Organic Cyclic Compound Negative Regulation Of Protein Metabolic Process Negative Regulation Of Receptor Biosynthetic Process Peroxisome Proliferator Activated Receptor Signaling Pathway
Tagcloud ?			calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia3 pdia4 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization
Tagcloud (Difference) ?			calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia3 pdia4 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization
Tagcloud (Intersection) ?