PDIA2 and CALR

Number of citations of the paper that reports this interaction (PMID 8537405)
18

Data Source:
HPRD (in vitro, in vivo)

		PDIA2	CALR
Gene Name		protein disulfide isomerase family A, member 2	calreticulin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Acrosomal Vesicle Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Intracellular Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Polysome Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Sarcoplasmic Reticulum Lumen MHC Class I Peptide Loading Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Endocytic Vesicle Lumen
	Molecular Function	Protein Disulfide Isomerase Activity Steroid Binding Protein Binding Peptidyl-proline 4-dioxygenase Activity	Complement Component C1q Binding Glycoprotein Binding DNA Binding MRNA Binding Integrin Binding Iron Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Carbohydrate Binding Ubiquitin Protein Ligase Binding Peptide Binding Hormone Binding Protein Binding Involved In Protein Folding Poly(A) RNA Binding Androgen Receptor Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Protein Folding Protein Retention In ER Lumen Peptidyl-proline Hydroxylation Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Transcription, DNA-templated Protein Folding Protein Export From Nucleus Cellular Calcium Ion Homeostasis Receptor-mediated Endocytosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest Spermatogenesis Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Translation Protein N-linked Glycosylation Via Asparagine Protein Maturation By Protein Folding Cortical Actin Cytoskeleton Organization Endoplasmic Reticulum Unfolded Protein Response Response To Estradiol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Testosterone Protein Localization To Nucleus Regulation Of Meiosis Response To Drug Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Glucocorticoid Receptor Signaling Pathway Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phagocytosis Protein Stabilization Sequestering Of Calcium Ion Cardiac Muscle Cell Differentiation Chaperone-mediated Protein Folding Cellular Response To Lithium Ion Cellular Senescence Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Dendritic Cell Chemotaxis
Pathways			Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Virus Assembly and Release Defective MOGS causes MOGS-CDG (CDG-2b) Influenza Life Cycle Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Scavenging by Class F Receptors Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Scavenging by Class A Receptors Assembly of Viral Components at the Budding Site ATF6-alpha activates chaperones Unfolded Protein Response (UPR) Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) ATF6-alpha activates chaperone genes Influenza Infection Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Antigen processing-Cross presentation ER-Phagosome pathway Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle
Drugs
Diseases
GWAS			Red blood cell traits ( 23222517)
Protein-Protein Interactions		7 interactors: CALR COL2A1 CUL3 GAPDH P4HTM PPARG SST	39 interactors: APOB APP AR B2M CD1D F5 F8 FBN1 FGB HLA-A HLA-C HLA-E ITGA2B ITGA3 ITGAV LPL LRIF1 LRP1 MAPK6 MBL2 MTNR1A NKX2-1 NR3C1 PDIA2 PDIA3 PLAT PLP1 PRF1 SCARF1 SLC2A1 SLC6A4 SMARCB1 SUMO4 TAPBP TF THBS1 TSHR UPF2 VWF
Entrez ID		64714	811
HPRD ID		07617	00169
Ensembl ID		ENSG00000185615	ENSG00000179218
Uniprot IDs		Q13087	P27797
PDB IDs			2CLR 3DOW 3POS 3POW
Enriched GO Terms of Interacting Partners?		Cellular Response To Lithium Ion Response To Lithium Ion Cellular Response To Organic Substance Positive Regulation Of Phagocytosis Apoptotic Process Programmed Cell Death Cell Death Death Negative Regulation Of Signal Transduction Regulation Of Phagocytosis Negative Regulation Of Signaling Response To Organic Substance Response To Steroid Hormone Negative Regulation Of Translation Response To Metformin Low-density Lipoprotein Particle Receptor Biosynthetic Process Peptide Antigen Assembly With MHC Class I Protein Complex Negative Regulation Of Pancreatic Stellate Cell Proliferation Peptidyl-cysteine S-trans-nitrosylation Response To Diuretic Protein Stabilization Response To Drug Heart Development Positive Regulation Of Endocytosis Regulation Of Cell Proliferation Regulation Of DNA Replication Cellular Response To Metal Ion Regulation Of Cholesterol Transporter Activity Cellular Response To Vitamin E Hormone-mediated Signaling Pathway Regulation Of Protein Stability Cellular Response To Inorganic Substance Cell Cycle Arrest Trophectodermal Cellular Morphogenesis Sequestering Of Calcium Ion Regulation Of Endocytosis Negative Regulation Of Cellular Protein Metabolic Process Response To Temperature Stimulus Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Collagen Biosynthetic Process Peptidyl-cysteine S-nitrosylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Response To Lipid Cardiovascular System Development Response To Estrogen Response To Organic Cyclic Compound Negative Regulation Of Protein Metabolic Process Negative Regulation Of Receptor Biosynthetic Process Peroxisome Proliferator Activated Receptor Signaling Pathway	Response To Stimulus Response To Stress Platelet Degranulation Blood Coagulation Hemostasis Antigen Processing And Presentation Of Endogenous Antigen Regulation Of Body Fluid Levels Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Wound Healing Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cell Activation Response To Wounding Platelet Activation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Exocytosis Response To External Stimulus Cellular Response To Stimulus Immune System Process Extracellular Matrix Organization Extracellular Structure Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Defense Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I System Development Secretion By Cell Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Cell Communication Immune Response Behavior Positive Regulation Of Leukocyte Mediated Cytotoxicity Transport Secretion Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Protection From Natural Killer Cell Mediated Cytotoxicity Signaling Multicellular Organismal Development Signal Transduction Negative Regulation Of Signaling Cell Adhesion Response To Hormone Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Anatomical Structure Development Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Organic Substance
Tagcloud ?		calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia3 pdia4 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization	administrating aspirin avws busulfan calreticulin erythrocytosis expectancy extreme failures fibrotic hematocrit hematol hydroxyurea leukocytosis microcirculatory periodicals phlebotomy prefibrotic pruritus pv splenomegaly stratification survivals thrombocytosis thrombohemorrhagic thrombosis von wiley willebrand
Tagcloud (Difference) ?		calnexin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia3 pdia4 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization	administrating aspirin avws busulfan erythrocytosis expectancy extreme failures fibrotic hematocrit hematol hydroxyurea leukocytosis microcirculatory periodicals phlebotomy prefibrotic pruritus pv splenomegaly stratification survivals thrombocytosis thrombohemorrhagic thrombosis von wiley willebrand
Tagcloud (Intersection) ?		calreticulin