POU3F1 and HMGA1

Number of citations of the paper that reports this interaction (PMID 7791781)
33

Data Source:
HPRD (in vivo, in vitro)

		POU3F1	HMGA1
Gene Name		POU class 3 homeobox 1	high mobility group AT-hook 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleus Nucleoplasm Transcription Factor Complex Cytosol Focal Adhesion Senescence-associated Heterochromatin Focus
	Molecular Function	RNA Polymerase II Transcription Coactivator Activity Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding	DNA Binding AT DNA Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Protein Binding Transcription Factor Binding Enzyme Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Retinoid X Receptor Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	Transcription, DNA-templated Axon Ensheathment Positive Regulation Of Gene Expression Myelination In Peripheral Nervous System Keratinocyte Differentiation Forebrain Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	DNA Catabolic Process, Endonucleolytic DNA Unwinding Involved In DNA Replication Base-excision Repair Nucleosome Disassembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Negative Regulation Of Cell Proliferation Response To Virus Viral Process Negative Regulation Of Chromatin Silencing Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Establishment Of Integrated Proviral Latency Oncogene-induced Cell Senescence Positive Regulation Of Cellular Senescence
Pathways			DNA Damage/Telomere Stress Induced Senescence Vpr-mediated nuclear import of PICs HIV Infection Cellular Senescence Host Interactions of HIV factors Integration of provirus Interactions of Vpr with host cellular proteins Early Phase of HIV Life Cycle Autointegration results in viral DNA circles HIV Life Cycle Formation of Senescence-Associated Heterochromatin Foci (SAHF) 2-LTR circle formation Integration of viral DNA into host genomic DNA APOBEC3G mediated resistance to HIV-1 infection
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 20453842) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-to-hip circumference ratio (interaction) ( 23192594)	Body mass index ( 20935630) Height ( 21998595 20881960 19396169 19343178 19893584 23563607 18391951 20397748 20189936)
Protein-Protein Interactions		3 interactors: HMGA1 HMGB2 POU3F4	60 interactors: ANXA1 ANXA2 APEX1 ATF2 CDK1 CEBPB CREBBP CSNK2A1 CSNK2A2 CWC27 DNAJC8 EIF2S2 ELF1 EWSR1 GTF2F2 HIPK2 HMGB1 HMGB2 HMGB3 HNRNPA1 HNRNPAB HNRNPD HNRNPDL HNRNPL HSPA1A IRF1 JUN KAT2B METAP2 NCL NFKB1 NFYA NPM1 OLA1 ORC6 PA2G4 PARP1 PCBP1 PCBP2 POU2F1 POU2F2 POU3F1 PPARG PPP1R8 PRKCA PRMT6 PSIP1 PTBP1 RARA RARG RCC1 RN7SK RNF4 RXRA SP1 SRF SSB SUFU SYNCRIP UPF2
Entrez ID		5453	3159
HPRD ID		03921	02829
Ensembl ID		ENSG00000185668	ENSG00000137309
Uniprot IDs		Q03052	P17096 Q5T6U8
PDB IDs			2EZD 2EZE 2EZF 2EZG
Enriched GO Terms of Interacting Partners?		Base-excision Repair DNA Catabolic Process, Endonucleolytic Chromatin Assembly DNA Catabolic Process Nucleosome Organization Chromatin Assembly Or Disassembly Chromatin Remodeling DNA Packaging Oncogene-induced Cell Senescence Senescence-associated Heterochromatin Focus Assembly DNA Conformation Change Positive Regulation Of Cellular Senescence Nucleic Acid Phosphodiester Bond Hydrolysis Base-excision Repair, DNA Ligation Negative Regulation Of Chromatin Silencing Establishment Of Integrated Proviral Latency Positive Regulation Of Cell Aging Aromatic Compound Catabolic Process Establishment Of Viral Latency Positive Regulation Of Megakaryocyte Differentiation DNA Ligation Involved In DNA Repair Heterochromatin Assembly Negative Regulation Of Mesenchymal Cell Apoptotic Process DNA Unwinding Involved In DNA Replication DNA Ligation Nucleosome Disassembly Heterochromatin Organization DNA Repair Chromatin Modification Positive Regulation Of Gene Expression, Epigenetic Regulation Of Megakaryocyte Differentiation Apoptotic DNA Fragmentation Positive Regulation Of Erythrocyte Differentiation Response To Other Organism Chromatin Organization Regulation Of Gene Silencing Response To Biotic Stimulus Regulation Of Cellular Senescence Cochlea Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Chemotaxis Spermatid Nucleus Differentiation V(D)J Recombination Cellular Senescence Cellular Response To DNA Damage Stimulus Apoptotic Nuclear Changes Cellular Macromolecule Catabolic Process Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Topological Change Negative Regulation Of Apoptotic Process	Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Gene Expression Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Biosynthetic Process RNA Splicing, Via Transesterification Reactions Negative Regulation Of Gene Expression RNA Splicing Biosynthetic Process Negative Regulation Of Transcription, DNA-templated RNA Processing Transcription Initiation From RNA Polymerase II Promoter MRNA Processing Regulation Of Cell Cycle Viral Process Cell Differentiation Metabolic Process DNA-templated Transcription, Initiation Cellular Response To Organic Substance Developmental Process Regulation Of Cell Differentiation
Tagcloud ?		acting additive c38 c40 caat cebpa cebpb collectively commitment composed concert elusive embryonic enhancer epidermis evolutionary fate keratinocyte keratinocytes layer modules p63 p63lre partly pluripotent redundant repress robust	arresting attribute augments bcl2 concomitantly e2 e6 evidences g0 galactosidase hmgb1 hpv16 htert kb linking mechanistic messaging papilloma re senescence senescent sensitizes shifted siha survivin sustaining tendency tnf tumorigenesis
Tagcloud (Difference) ?		acting additive c38 c40 caat cebpa cebpb collectively commitment composed concert elusive embryonic enhancer epidermis evolutionary fate keratinocyte keratinocytes layer modules p63 p63lre partly pluripotent redundant repress robust	arresting attribute augments bcl2 concomitantly e2 e6 evidences g0 galactosidase hmgb1 hpv16 htert kb linking mechanistic messaging papilloma re senescence senescent sensitizes shifted siha survivin sustaining tendency tnf tumorigenesis
Tagcloud (Intersection) ?