POU3F1 and HMGB2

Number of citations of the paper that reports this interaction (PMID 7720710)
71

Data Source:
HPRD (in vivo, in vitro)

		POU3F1	HMGB2
Gene Name		POU class 3 homeobox 1	high mobility group box 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Condensed Chromosome Extracellular Space Nucleus Nucleoplasm Cytoplasm Protein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Coactivator Activity Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding	DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Transcription Regulatory Region DNA Binding Poly(A) RNA Binding RAGE Receptor Binding
	Biological Process	Transcription, DNA-templated Axon Ensheathment Positive Regulation Of Gene Expression Myelination In Peripheral Nervous System Keratinocyte Differentiation Forebrain Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Positive Regulation Of Endothelial Cell Proliferation DNA Topological Change Base-excision Repair, DNA Ligation Apoptotic DNA Fragmentation Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Spermatid Nucleus Differentiation Male Gonad Development Positive Regulation Of Nuclease Activity V(D)J Recombination Positive Regulation Of DNA Binding Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Positive Chemotaxis DNA Ligation Involved In DNA Repair Cell Chemotaxis Cellular Response To Lipopolysaccharide Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways			Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 20453842) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-Protein Interactions		3 interactors: HMGA1 HMGB2 POU3F4	20 interactors: APEX1 APP AR CHAF1A CREBBP CSNK1A1 GZMA GZMK HMGA1 NR3C1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 SET TP53
Entrez ID		5453	3148
HPRD ID		03921	01229
Ensembl ID		ENSG00000185668
Uniprot IDs		Q03052	P26583
PDB IDs
Enriched GO Terms of Interacting Partners?		Base-excision Repair DNA Catabolic Process, Endonucleolytic Chromatin Assembly DNA Catabolic Process Nucleosome Organization Chromatin Assembly Or Disassembly Chromatin Remodeling DNA Packaging Oncogene-induced Cell Senescence Senescence-associated Heterochromatin Focus Assembly DNA Conformation Change Positive Regulation Of Cellular Senescence Nucleic Acid Phosphodiester Bond Hydrolysis Base-excision Repair, DNA Ligation Negative Regulation Of Chromatin Silencing Establishment Of Integrated Proviral Latency Positive Regulation Of Cell Aging Aromatic Compound Catabolic Process Establishment Of Viral Latency Positive Regulation Of Megakaryocyte Differentiation DNA Ligation Involved In DNA Repair Heterochromatin Assembly Negative Regulation Of Mesenchymal Cell Apoptotic Process DNA Unwinding Involved In DNA Replication DNA Ligation Nucleosome Disassembly Heterochromatin Organization DNA Repair Chromatin Modification Positive Regulation Of Gene Expression, Epigenetic Regulation Of Megakaryocyte Differentiation Apoptotic DNA Fragmentation Positive Regulation Of Erythrocyte Differentiation Response To Other Organism Chromatin Organization Regulation Of Gene Silencing Response To Biotic Stimulus Regulation Of Cellular Senescence Cochlea Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Chemotaxis Spermatid Nucleus Differentiation V(D)J Recombination Cellular Senescence Cellular Response To DNA Damage Stimulus Apoptotic Nuclear Changes Cellular Macromolecule Catabolic Process Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Topological Change Negative Regulation Of Apoptotic Process	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Chromosome Organization Macromolecule Biosynthetic Process Regulation Of Metabolic Process Organ Development Chromatin Organization Cellular Metabolic Process Developmental Process Lymphocyte Differentiation B Cell Differentiation Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chromatin Assembly Leukocyte Differentiation T Cell Differentiation Chromatin Assembly Or Disassembly B Cell Activation Positive Regulation Of Cell Aging Transcription Initiation From RNA Polymerase II Promoter B Cell Lineage Commitment Cell Activation Multicellular Organismal Development DNA Metabolic Process DNA Packaging Lymphocyte Activation Intracellular Receptor Signaling Pathway
Tagcloud ?		acting additive c38 c40 caat cebpa cebpb collectively commitment composed concert elusive embryonic enhancer epidermis evolutionary fate keratinocyte keratinocytes layer modules p63 p63lre partly pluripotent redundant repress robust	advance aromatase bioinformatic chipseq coactivator concise contexts coregulatory ddx18 defines doi endocrine helicase integration october oestrogen onc online partners publication resistant reveals setting src steroid switch switched tamoxifen verified
Tagcloud (Difference) ?		acting additive c38 c40 caat cebpa cebpb collectively commitment composed concert elusive embryonic enhancer epidermis evolutionary fate keratinocyte keratinocytes layer modules p63 p63lre partly pluripotent redundant repress robust	advance aromatase bioinformatic chipseq coactivator concise contexts coregulatory ddx18 defines doi endocrine helicase integration october oestrogen onc online partners publication resistant reveals setting src steroid switch switched tamoxifen verified
Tagcloud (Intersection) ?