PGGT1B and RRAS2

Number of citations of the paper that reports this interaction (PMID 15451670)
58

Data Source:
HPRD (in vitro)

		PGGT1B	RRAS2
Gene Name		protein geranylgeranyltransferase type I, beta subunit	related RAS viral (r-ras) oncogene homolog 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	CAAX-protein Geranylgeranyltransferase Complex	Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Drug Binding Zinc Ion Binding Isoprenoid Binding Peptide Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Positive Regulation Of Cell Proliferation Protein Geranylgeranylation Response To Cytokine Positive Regulation Of Cell Cycle Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death
Pathways
Drugs		4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE GERANYLGERANYL DIPHOSPHATE 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		5 interactors: CDC42 GNG2 KRAS RHOB RRAS2	29 interactors: ACVR1 AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB LGALS4 MLLT4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6
Entrez ID		5229	22800
HPRD ID		03612	02518
Ensembl ID		ENSG00000164219	ENSG00000133818
Uniprot IDs		P53609	B7Z5Z2 P62070
PDB IDs			2ERY
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Small GTPase Mediated Signal Transduction Response To Wounding Ras Protein Signal Transduction Regulation Of Neuron Death Axon Guidance Regulation Of Cell Death Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Vascular Endothelial Growth Factor Receptor Signaling Pathway Intracellular Signal Transduction Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Small GTPase Mediated Signal Transduction Neuron Projection Development Positive Regulation Of Hair Follicle Cell Proliferation Cell Projection Morphogenesis Cell Part Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Signal Transduction Actin Filament Branching Submandibular Salivary Gland Formation Neuron Development Platelet Activation Signaling Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Cell Morphogenesis Cell Communication Leukocyte Migration Positive Regulation Of Rac Protein Signal Transduction Regulation Of Neuron Apoptotic Process Neuron Differentiation Cell Projection Organization Establishment Of Golgi Localization Fc Receptor Signaling Pathway Transformed Cell Apoptotic Process Positive Regulation Of Metalloenzyme Activity Locomotion Cellular Response To Peptide Hormone Stimulus Neuron Fate Determination Epithelial-mesenchymal Cell Signaling Cellular Response To Stimulus Muscle Cell Differentiation	Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Metabolic Process Signal Transduction Response To Stimulus Signaling Cell Communication Positive Regulation Of Metabolic Process Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Catalytic Activity Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Hydrolase Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Phosphorylation Response To Growth Factor Regulation Of Intracellular Signal Transduction Endothelial Cell Differentiation Positive Regulation Of Catalytic Activity Regulation Of Cell Death Endothelium Development Regulation Of Cellular Protein Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Process Regulation Of GTPase Activity Response To Stress Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Negative Regulation Of Cell Death Positive Regulation Of Rap GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Bone Mineralization Defense Response BMP Signaling Pathway Regulation Of Cytokine Production Regulation Of Ras GTPase Activity Regulation Of Protein Localization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?