RRAS2 and RASSF5

Number of citations of the paper that reports this interaction (PMID 11857081)
43

Data Source:
HPRD (in vitro)

		RRAS2	RASSF5
Gene Name		related RAS viral (r-ras) oncogene homolog 2	Ras association (RalGDS/AF-6) domain family member 5
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Microtubule
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Protein Binding Metal Ion Binding
	Biological Process	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death	Apoptotic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Protein Ubiquitination Intracellular Signal Transduction Regulation Of Protein Localization To Nucleus
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		29 interactors: ACVR1 AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB LGALS4 MLLT4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6	31 interactors: ADH6 AMOTL2 APPBP2 BTRC HRAS KRAS KRT40 KRTAP4-2 LSM7 MAP1S MRAS MYLIP NRAS RABIF RALA RAP1B RAP2A RAP2B RASSF1 RASSF2 REL RRAS RRAS2 SMAD4 STK3 STK4 TERF2IP TRAF1 TRAF2 UBQLN1 VPS28
Entrez ID		22800	83593
HPRD ID		02518	06117
Ensembl ID		ENSG00000133818	ENSG00000136653
Uniprot IDs		B7Z5Z2 P62070	Q8WWW0
PDB IDs		2ERY	4LGD
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Metabolic Process Signal Transduction Response To Stimulus Signaling Cell Communication Positive Regulation Of Metabolic Process Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Catalytic Activity Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Hydrolase Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Phosphorylation Response To Growth Factor Regulation Of Intracellular Signal Transduction Endothelial Cell Differentiation Positive Regulation Of Catalytic Activity Regulation Of Cell Death Endothelium Development Regulation Of Cellular Protein Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Process Regulation Of GTPase Activity Response To Stress Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Negative Regulation Of Cell Death Positive Regulation Of Rap GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Bone Mineralization Defense Response BMP Signaling Pathway Regulation Of Cytokine Production Regulation Of Ras GTPase Activity Regulation Of Protein Localization	Ras Protein Signal Transduction Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Signaling Cell Communication Regulation Of Signaling Response To Stimulus Branching Morphogenesis Of An Epithelial Tube Regulation Of Phosphorylation Rap Protein Signal Transduction Positive Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Epithelial Tube Morphogenesis Morphogenesis Of A Branching Epithelium Regulation Of MAPK Cascade Morphogenesis Of A Branching Structure Regulation Of Phosphorus Metabolic Process Tube Morphogenesis Endocardium Development Regulation Of Cell Death Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Neuron Death Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Morphogenesis Of An Epithelium Positive Regulation Of Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Neuron Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Hippo Signaling Neurotrophin Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Tissue Morphogenesis Regulation Of Synaptic Transmission, GABAergic
Tagcloud ?			action activates acts allows arrest catenin dictate effector exhibit explanation frequently ikappab ligase lost nore1a observation oncogene promoted promoting proteasome scf stimulate substrate suppressor toward trcp ubiquitin wnt
Tagcloud (Difference) ?			action activates acts allows arrest catenin dictate effector exhibit explanation frequently ikappab ligase lost nore1a observation oncogene promoted promoting proteasome scf stimulate substrate suppressor toward trcp ubiquitin wnt
Tagcloud (Intersection) ?