VPS29 and RGS2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		VPS29	RGS2
Gene Name		vacuolar protein sorting 29 homolog (S. cerevisiae)	regulator of G-protein signaling 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Retromer Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Neuron Projection
	Molecular Function	Protein Binding Zinc Ion Binding Protein Transporter Activity	GTPase Activator Activity Protein Binding Calmodulin Binding Beta-tubulin Binding
	Biological Process	Intracellular Protein Transport Retrograde Transport, Endosome To Golgi Retrograde Transport, Endosome To Plasma Membrane	Regulation Of Translation Cell Cycle Spermatogenesis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Phospholipase Activity Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Microtubule Polymerization Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Brown Fat Cell Differentiation Relaxation Of Cardiac Muscle Relaxation Of Vascular Smooth Muscle Positive Regulation Of Cardiac Muscle Contraction Regulation Of Adrenergic Receptor Signaling Pathway
Pathways		WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking	G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APP FRA10AC1 RGS2 TBC1D5 VPS35	58 interactors: ADCY5 ADRA1A ADRB2 ARFGAP1 BBS10 CALM1 CHD3 CLTA COMT COPB1 COPB2 CRMP1 CTSB DDR1 DUSP21 DYNLL1 EIF3L FZD5 GDE1 GIT1 GNA15 GNAI3 GNAQ GNAS HAUS5 HSPA8 IER3IP1 KIAA1377 KLK8 LIG1 LRFN1 METTL18 MON1A MTUS2 NINL NIPSNAP1 PARK2 PPP1R9B PRKCA PRKCB PRKCG PRKCSH PRKG1 RAB2A RABAC1 RAP1B REEP5 RIN3 SCN5A TSPAN15 TUBB2B UBC VPS29 WDR74 XRCC6 ZBTB48 ZNF579 ZYX
Entrez ID		51699	5997
HPRD ID		09499	02917
Ensembl ID		ENSG00000111237	ENSG00000116741
Uniprot IDs		F8VXU5 Q9UBQ0	P41220
PDB IDs		1W24 2R17	2AF0 2V4Z 4EKC 4EKD
Enriched GO Terms of Interacting Partners?		Retrograde Transport, Endosome To Golgi Synaptic Growth At Neuromuscular Junction Negative Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of Hydrolase Activity Endosomal Transport Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Translation Vesicle-mediated Transport Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Adrenergic Receptor Signaling Pathway Intracellular Transport Positive Regulation Of Catalytic Activity Axon Choice Point Recognition Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Neuron Remodeling Relaxation Of Vascular Smooth Muscle Retrograde Transport, Endosome To Plasma Membrane Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Hydrolase Activity Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Transcytosis Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Microtubule Polymerization Relaxation Of Cardiac Muscle Establishment Of Localization In Cell Negative Regulation Of Smooth Muscle Contraction Cellular Copper Ion Homeostasis Positive Regulation Of Receptor Internalization Negative Regulation Of Lipase Activity Negative Regulation Of Muscle Contraction Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Copper Ion Homeostasis Suckling Behavior Regulation Of Catalytic Activity Cellular Localization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Cardiac Muscle Hypertrophy Regulation Of Receptor Internalization	Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Platelet Activation Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Catalytic Activity Regulation Of Body Fluid Levels Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Wounding Blood Coagulation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Hemostasis Wound Healing Cell-cell Signaling Regulation Of Phosphorus Metabolic Process Regulation Of Adenylate Cyclase Activity Nervous System Development Regulation Of Cyclase Activity Activation Of Adenylate Cyclase Activity Signaling Response To Stress Neurotrophin Signaling Pathway Cell Communication Regulation Of Phosphorylation Dopamine Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Developmental Process Positive Regulation Of Adenylate Cyclase Activity Regulation Of Kinase Activity Response To Organic Substance Cellular Response To Stimulus Regulation Of Muscle Contraction Anatomical Structure Development Regulation Of CAMP Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Positive Regulation Of Hydrolase Activity Cell Activation Membrane Organization Regulation Of CAMP Metabolic Process Regulation Of Protein Phosphorylation System Development Positive Regulation Of Lyase Activity Enzyme Linked Receptor Protein Signaling Pathway Golgi Vesicle Budding Adrenergic Receptor Signaling Pathway
Tagcloud ?		branched building cargo comprises coordinate dimer dysregulation endosomal endosome fam21 laboratories nexins operate recruits retromer rme snx1 sort sorting subcomplexes trimer tubulate tubulating tubulation tubules vital vps26 vps35 wash	3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rho seemed steps takes tc10 vdr
Tagcloud (Difference) ?		branched building cargo comprises coordinate dimer dysregulation endosomal endosome fam21 laboratories nexins operate recruits retromer rme snx1 sort sorting subcomplexes trimer tubulate tubulating tubulation tubules vital vps26 vps35 wash	3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rho seemed steps takes tc10 vdr
Tagcloud (Intersection) ?