VPS29

Gene Name		vacuolar protein sorting 29 homolog (S. cerevisiae)
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Gene Ontology Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Retromer Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Protein Transporter Activity
	Biological Process	Intracellular Protein Transport Retrograde Transport, Endosome To Golgi Retrograde Transport, Endosome To Plasma Membrane
Pathways		WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: APP FRA10AC1 RGS2 TBC1D5 VPS35
Entrez ID		51699
HPRD ID		09499
Ensembl ID		ENSG00000111237
Uniprot IDs		F8VXU5 Q9UBQ0
PDB IDs		1W24 2R17
Enriched GO Terms of Interacting Partners?		Retrograde Transport, Endosome To Golgi Synaptic Growth At Neuromuscular Junction Negative Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of Hydrolase Activity Endosomal Transport Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Translation Vesicle-mediated Transport Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Adrenergic Receptor Signaling Pathway Intracellular Transport Positive Regulation Of Catalytic Activity Axon Choice Point Recognition Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Neuron Remodeling Relaxation Of Vascular Smooth Muscle Retrograde Transport, Endosome To Plasma Membrane Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Hydrolase Activity Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Transcytosis Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Microtubule Polymerization Relaxation Of Cardiac Muscle Establishment Of Localization In Cell Negative Regulation Of Smooth Muscle Contraction Cellular Copper Ion Homeostasis Positive Regulation Of Receptor Internalization Negative Regulation Of Lipase Activity Negative Regulation Of Muscle Contraction Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Copper Ion Homeostasis Suckling Behavior Regulation Of Catalytic Activity Cellular Localization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Cardiac Muscle Hypertrophy Regulation Of Receptor Internalization
Tagcloud ?		branched building cargo comprises coordinate dimer dysregulation endosomal endosome fam21 laboratories nexins operate recruits retromer rme snx1 sort sorting subcomplexes trimer tubulate tubulating tubulation tubules vital vps26 vps35 wash