PDE3B and ANKRA2

Number of citations of the paper that reports this interaction (PMID 22649097)
2

Data Source:
BioGRID (unspecified method)

		PDE3B	ANKRA2
Gene Name		phosphodiesterase 3B, cGMP-inhibited	ankyrin repeat, family A (RFXANK-like), 2
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Cytosol Membrane Integral Component Of Membrane Guanyl-nucleotide Exchange Factor Complex	Nucleus Cytosol Cytoskeleton Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity CGMP-inhibited Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Protein Kinase B Binding Metal Ion Binding	Transcription Cofactor Activity Low-density Lipoprotein Particle Binding Histone Deacetylase Binding
	Biological Process	Angiogenesis CAMP Catabolic Process Negative Regulation Of Cell Adhesion Blood Coagulation Insulin Receptor Signaling Pathway Negative Regulation Of Angiogenesis Endocrine Pancreas Development Cellular Response To Insulin Stimulus Negative Regulation Of Cell Adhesion Mediated By Integrin Glucose Homeostasis Negative Regulation Of CAMP-mediated Signaling Regulation Of Insulin Secretion Negative Regulation Of Lipid Catabolic Process	Regulation Of Transcription From RNA Polymerase II Promoter Biological_process
Pathways		Signaling by GPCR Insulin receptor signalling cascade G alpha (s) signalling events IRS-mediated signalling IRS-related events PDE3B signalling cGMP effects IGF1R signaling cascade IRS-related events triggered by IGF1R GPCR downstream signaling IRS-mediated signalling Platelet homeostasis Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Nitric oxide stimulates guanylate cyclase PKB-mediated events PKB-mediated events PDE3B signalling PI3K Cascade PI3K Cascade Signaling by Insulin receptor
Drugs		(5r)-6-(4-{[2-(3-Iodobenzyl)-3-Oxocyclohex-1-En-1-Yl]Amino}Phenyl)-5-Methyl-4,5-Dihydropyridazin-3(2h)-One Hg9a-9, Nonanoyl-N-Hydroxyethylglucamide 3-ISOBUTYL-1-METHYLXANTHINE
Diseases
GWAS
Protein-Protein Interactions		5 interactors: AKT1 ANKRA2 PRKACA YWHAB YWHAQ	10 interactors: ABL1 APP HDAC4 HDAC5 HDAC9 LRP2 MPL NEK6 PDE3B RFX5
Entrez ID		5140	57763
HPRD ID		03626	12044
Ensembl ID		ENSG00000152270	ENSG00000164331
Uniprot IDs		A7E2E5 B7ZM37 Q13370	Q9H9E1
PDB IDs		1SO2 1SOJ	3SO8 3V2O 3V2X 3V31 4LG6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Positive Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Regulation Of Intracellular Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Protein Localization Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Membrane Organization Apoptotic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Transport Positive Regulation Of Organelle Organization Protein Targeting Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Endothelial Cell Proliferation Response To Peptide Hormone Regulation Of Apoptotic Process Regulation Of Glucose Import Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Response To Peptide Positive Regulation Of Kinase Activity Regulation Of Cell Death Positive Regulation Of Epithelial Cell Migration Regulation Of Endothelial Cell Proliferation Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus	Regulation Of Skeletal Muscle Fiber Development B Cell Differentiation Cell Activation Histone H4 Deacetylation Regulation Of Muscle Cell Differentiation Histone H3 Deacetylation B Cell Activation Histone H3-K9 Modification Regulation Of Myotube Differentiation Collateral Sprouting Regulation Of Skeletal Muscle Tissue Development Lymphocyte Differentiation Histone Deacetylation Protein Deacetylation Peptidyl-lysine Deacetylation Regulation Of Striated Muscle Cell Differentiation Response To Stress Leukocyte Differentiation Signal Transduction Negative Regulation Of Myotube Differentiation Lymphocyte Activation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Blood Coagulation Regulation Of Striated Muscle Tissue Development Signaling Hemostasis Cell Communication Regulation Of Sprouting Angiogenesis Notch Signaling Pathway Regulation Of Protein Binding Cellular Response To Organonitrogen Compound Negative Regulation Of Striated Muscle Cell Differentiation Leukocyte Activation Organ Development Osteoblast Development Regulation Of Cellular Senescence Regulation Of Body Fluid Levels Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Wound Healing Cellular Response To Stimulus Cellular Response To Insulin Stimulus Hemopoiesis Regulation Of Angiogenesis Defense Response Response To Wounding Immune System Development Regulation Of Binding Negative Regulation Of Muscle Cell Differentiation Negative Regulation Of Osteoblast Differentiation
Tagcloud ?		amounts analogs camp cyclic decreases fact feedback glp glucagonlike hit igf immunoprecipitation inhibits insulin islets mediates nonhydrolyzable pancreatic parallel phosphodiesterase secretagogues secreted secreting secretion stimulate substrates t15 turn	ankyrin deacetylases docking hdac4 hdac5 hdac9 iia lock megalin motif operate paralog preference principle proteome pxlpxi recognize recognizes repeat repeats residue rfx5 rfxank sequester serving switch tumbler uncharacterized uncover
Tagcloud (Difference) ?		amounts analogs camp cyclic decreases fact feedback glp glucagonlike hit igf immunoprecipitation inhibits insulin islets mediates nonhydrolyzable pancreatic parallel phosphodiesterase secretagogues secreted secreting secretion stimulate substrates t15 turn	ankyrin deacetylases docking hdac4 hdac5 hdac9 iia lock megalin motif operate paralog preference principle proteome pxlpxi recognize recognizes repeat repeats residue rfx5 rfxank sequester serving switch tumbler uncharacterized uncover
Tagcloud (Intersection) ?