ANKRA2 and MPL

Number of citations of the paper that reports this interaction (PMID 22649097)
2

Data Source:
BioGRID (unspecified method)

		ANKRA2	MPL
Gene Name		ankyrin repeat, family A (RFXANK-like), 2	MPL proto-oncogene, thrombopoietin receptor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Transcription Cofactor Activity Low-density Lipoprotein Particle Binding Histone Deacetylase Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Biological_process	Cell Surface Receptor Signaling Pathway Blood Coagulation Cell Proliferation Cytokine-mediated Signaling Pathway Platelet Activation Regulation Of Chemokine Production Homeostasis Of Number Of Cells
Pathways			Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ABL1 APP HDAC4 HDAC5 HDAC9 LRP2 MPL NEK6 PDE3B RFX5	9 interactors: ANKRA2 ATXN2L IRS2 JAK2 PTPN11 SHC1 SOCS1 THPO YWHAQ
Entrez ID		57763	4352
HPRD ID		12044	01161
Ensembl ID		ENSG00000164331	ENSG00000117400
Uniprot IDs		Q9H9E1	P40238
PDB IDs		3SO8 3V2O 3V2X 3V31 4LG6
Enriched GO Terms of Interacting Partners?		Regulation Of Skeletal Muscle Fiber Development B Cell Differentiation Cell Activation Histone H4 Deacetylation Regulation Of Muscle Cell Differentiation Histone H3 Deacetylation B Cell Activation Histone H3-K9 Modification Regulation Of Myotube Differentiation Collateral Sprouting Regulation Of Skeletal Muscle Tissue Development Lymphocyte Differentiation Histone Deacetylation Protein Deacetylation Peptidyl-lysine Deacetylation Regulation Of Striated Muscle Cell Differentiation Response To Stress Leukocyte Differentiation Signal Transduction Negative Regulation Of Myotube Differentiation Lymphocyte Activation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Blood Coagulation Regulation Of Striated Muscle Tissue Development Signaling Hemostasis Cell Communication Regulation Of Sprouting Angiogenesis Notch Signaling Pathway Regulation Of Protein Binding Cellular Response To Organonitrogen Compound Negative Regulation Of Striated Muscle Cell Differentiation Leukocyte Activation Organ Development Osteoblast Development Regulation Of Cellular Senescence Regulation Of Body Fluid Levels Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Wound Healing Cellular Response To Stimulus Cellular Response To Insulin Stimulus Hemopoiesis Regulation Of Angiogenesis Defense Response Response To Wounding Immune System Development Regulation Of Binding Negative Regulation Of Muscle Cell Differentiation Negative Regulation Of Osteoblast Differentiation	Cellular Response To Peptide Hormone Stimulus Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Peptide JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Growth Hormone Response To Peptide JAK-STAT Cascade Cellular Response To Hormone Stimulus Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Response To Organonitrogen Compound Positive Regulation Of Hormone Secretion Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Response To Hormone Interferon-gamma-mediated Signaling Pathway Blood Coagulation Hemostasis Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling Cellular Response To Interferon-gamma Regulation Of Protein Phosphorylation Insulin Receptor Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Interferon-gamma Negative Regulation Of Lipid Transport Immune System Process Regulation Of Body Fluid Levels Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Cytokine Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Signal Transduction Wound Healing Regulation Of Insulin Secretion
Tagcloud ?		ankyrin deacetylases docking hdac4 hdac5 hdac9 iia lock megalin motif operate paralog preference principle proteome pxlpxi recognize recognizes repeat repeats residue rfx5 rfxank sequester serving switch tumbler uncharacterized uncover	advances begun biology commitment correlate determination developmental dlk experimental flk gata genetic hematopoietic hoxb4 identify impact implicated loci major mapping numbers others recently regulators scl stem strategies strongly variety
Tagcloud (Difference) ?		ankyrin deacetylases docking hdac4 hdac5 hdac9 iia lock megalin motif operate paralog preference principle proteome pxlpxi recognize recognizes repeat repeats residue rfx5 rfxank sequester serving switch tumbler uncharacterized uncover	advances begun biology commitment correlate determination developmental dlk experimental flk gata genetic hematopoietic hoxb4 identify impact implicated loci major mapping numbers others recently regulators scl stem strategies strongly variety
Tagcloud (Intersection) ?