PDE3B

Gene Name		phosphodiesterase 3B, cGMP-inhibited
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Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Cytosol Membrane Integral Component Of Membrane Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity CGMP-inhibited Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Protein Kinase B Binding Metal Ion Binding
	Biological Process	Angiogenesis CAMP Catabolic Process Negative Regulation Of Cell Adhesion Blood Coagulation Insulin Receptor Signaling Pathway Negative Regulation Of Angiogenesis Endocrine Pancreas Development Cellular Response To Insulin Stimulus Negative Regulation Of Cell Adhesion Mediated By Integrin Glucose Homeostasis Negative Regulation Of CAMP-mediated Signaling Regulation Of Insulin Secretion Negative Regulation Of Lipid Catabolic Process
Pathways		Signaling by GPCR Insulin receptor signalling cascade G alpha (s) signalling events IRS-mediated signalling IRS-related events PDE3B signalling cGMP effects IGF1R signaling cascade IRS-related events triggered by IGF1R GPCR downstream signaling IRS-mediated signalling Platelet homeostasis Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Nitric oxide stimulates guanylate cyclase PKB-mediated events PKB-mediated events PDE3B signalling PI3K Cascade PI3K Cascade Signaling by Insulin receptor
Drugs		(5r)-6-(4-{[2-(3-Iodobenzyl)-3-Oxocyclohex-1-En-1-Yl]Amino}Phenyl)-5-Methyl-4,5-Dihydropyridazin-3(2h)-One Hg9a-9, Nonanoyl-N-Hydroxyethylglucamide 3-ISOBUTYL-1-METHYLXANTHINE
Diseases
GWAS
Protein-protein Interactions		5 interactors: AKT1 ANKRA2 PRKACA YWHAB YWHAQ
Entrez ID		5140
HPRD ID		03626
Ensembl ID		ENSG00000152270
Uniprot IDs		A7E2E5 B7ZM37 Q13370
PDB IDs		1SO2 1SOJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Positive Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Regulation Of Intracellular Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Protein Localization Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Membrane Organization Apoptotic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Signal Transduction Negative Regulation Of Transport Positive Regulation Of Organelle Organization Protein Targeting Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Endothelial Cell Proliferation Response To Peptide Hormone Regulation Of Apoptotic Process Regulation Of Glucose Import Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Response To Peptide Positive Regulation Of Kinase Activity Regulation Of Cell Death Positive Regulation Of Epithelial Cell Migration Regulation Of Endothelial Cell Proliferation Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus
Tagcloud ?		amounts analogs camp cyclic decreases fact feedback glp glucagonlike hit igf immunoprecipitation inhibits insulin islets mediates nonhydrolyzable pancreatic parallel phosphodiesterase secretagogues secreted secreting secretion stimulate substrates t15 turn