ASAP1 and REPS2

Number of citations of the paper that reports this interaction (PMID 12149250)
9

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		ASAP1	REPS2
Gene Name		ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	RALBP1 associated Eps domain containing 2
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Cytoplasm
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding ARF GTPase Activator Activity Zinc Ion Binding	Calcium Ion Binding Protein Binding
	Biological Process	Organelle Organization Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Cilium Morphogenesis	Protein Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance VxPx cargo-targeting to cilium Assembly of the primary cilium
Drugs
Diseases
GWAS		Multiple sclerosis ( 19525955)
Protein-Protein Interactions		13 interactors: ARF1 CBL CRK GRB2 HCK IKBKG PACSIN3 PTK2 PTK2B PXN REPS2 SH3KBP1 SRC	13 interactors: AR ASAP1 ASAP2 CDK1 CDK5RAP2 EPN1 EPS15 GRB2 PXN RALB RALBP1 RELA REPS1
Entrez ID		50807	9185
HPRD ID		05809	02262
Ensembl ID		ENSG00000153317	ENSG00000169891
Uniprot IDs		Q9ULH1	B4DQQ8 Q8NFH8
PDB IDs		2D1X 2DA0 2ED1 2RQT 2RQU	1IQ3
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Complex Assembly Regulation Of Cellular Component Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cell Surface Receptor Signaling Pathway Regulation Of Cell Shape Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Endocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Endocytosis Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Response To Peptide Hormone Positive Regulation Of Protein Kinase Activity Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Positive Regulation Of Kinase Activity Response To Peptide Regulation Of Cytoskeleton Organization Signal Transduction Positive Regulation Of Immune System Process Regulation Of Organelle Organization Phagocytosis Vesicle-mediated Transport Peptidyl-tyrosine Phosphorylation Activation Of Protein Kinase Activity Response To Hormone Positive Regulation Of Transferase Activity Regulation Of Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Signaling Response To Growth Factor Cell Communication Regulation Of MAPK Cascade	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Schwann Cell Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Hormone Stimulus Cellular Response To Growth Factor Stimulus Regulation Of ERBB Signaling Pathway Response To Growth Factor Regulation Of Intracellular Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Reactive Oxygen Species Cellular Response To Peptide Positive Regulation Of Catalytic Activity Response To Peptide Hormone Response To Hormone Cellular Response To Organonitrogen Compound Response To Peptide Response To Reactive Oxygen Species Protein Complex Assembly Cellular Response To Oxidative Stress Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Ras Protein Signal Transduction Fc-epsilon Receptor Signaling Pathway Cellular Response To Organic Substance Small GTPase Mediated Signal Transduction Negative Regulation Of Signaling Endocytosis Signal Transduction Fc Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Toll-like Receptor 10 Signaling Pathway Regulation Of Phosphorylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Response To Insulin Cellular Response To Hydrogen Peroxide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		actin apical associate bar basal base believed bleu cobl cordon curved ectopic localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited sh3 shortens snx9 syndapin unlikely wh2	amphiphysin arrays bioinformatics bridging cytoskeleton differently ectopic endocytosis leaving linking machinery mammals motifs mutagenic partner phage pob1 predictions proline ralbp1 recruiting rich scaffold sh3 spaced traffic transferrin unaffected vesicular
Tagcloud (Difference) ?		actin apical associate bar basal base believed bleu cobl cordon curved localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited shortens snx9 syndapin unlikely wh2	amphiphysin arrays bioinformatics bridging cytoskeleton differently endocytosis leaving linking machinery mammals motifs mutagenic partner phage pob1 predictions proline ralbp1 recruiting rich scaffold spaced traffic transferrin unaffected vesicular
Tagcloud (Intersection) ?		ectopic sh3