ASAP1 and SH3KBP1

Number of citations of the paper that reports this interaction (PMID 15719014)
33

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ASAP1	SH3KBP1
Gene Name		ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	SH3-domain kinase binding protein 1
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Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Cytoplasmic Vesicle Membrane Neuron Projection Synapse
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding ARF GTPase Activator Activity Zinc Ion Binding	Protein Binding SH3 Domain Binding
	Biological Process	Organelle Organization Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Cilium Morphogenesis	Endocytosis Apoptotic Process Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance VxPx cargo-targeting to cilium Assembly of the primary cilium	Signaling by the B Cell Receptor (BCR) Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
Drugs
Diseases
GWAS		Multiple sclerosis ( 19525955)
Protein-Protein Interactions		13 interactors: ARF1 CBL CRK GRB2 HCK IKBKG PACSIN3 PTK2 PTK2B PXN REPS2 SH3KBP1 SRC	45 interactors: ABI2 ARAP1 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CD2 GRB2 HCK INPP5D ITSN2 LMNA MVB12A NEDD4 PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 PSMA3 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SUMO1 SUMO2 SUMO3 SYNJ1 TAF6 TJP2 UBB UBC ZBTB7B ZNF219
Entrez ID		50807	30011
HPRD ID		05809	02301
Ensembl ID		ENSG00000153317	ENSG00000147010
Uniprot IDs		Q9ULH1	B7Z6E8 Q5JPT6 Q96B97
PDB IDs		2D1X 2DA0 2ED1 2RQT 2RQU	2BZ8 2K6D 2K9G 2O2O 2YDL
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Complex Assembly Regulation Of Cellular Component Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cell Surface Receptor Signaling Pathway Regulation Of Cell Shape Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Endocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Endocytosis Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Response To Peptide Hormone Positive Regulation Of Protein Kinase Activity Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Positive Regulation Of Kinase Activity Response To Peptide Regulation Of Cytoskeleton Organization Signal Transduction Positive Regulation Of Immune System Process Regulation Of Organelle Organization Phagocytosis Vesicle-mediated Transport Peptidyl-tyrosine Phosphorylation Activation Of Protein Kinase Activity Response To Hormone Positive Regulation Of Transferase Activity Regulation Of Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Signaling Response To Growth Factor Cell Communication Regulation Of MAPK Cascade	Regulation Of Signal Transduction Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Cellular Process Signaling Signal Transduction Cell Communication Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Fibroblast Growth Factor Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Cell Death Antigen Receptor-mediated Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Apoptotic Process Immune System Process Programmed Cell Death Cellular Response To Stimulus Cell Death Death Fc Receptor Signaling Pathway Immune Response Viral Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Endocytosis Locomotion Movement Of Cell Or Subcellular Component Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Catalytic Activity Regulation Of Immune Response
Tagcloud ?		actin apical associate bar basal base believed bleu cobl cordon curved ectopic localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited sh3 shortens snx9 syndapin unlikely wh2	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		actin apical associate bar basal base believed bleu cobl cordon curved ectopic localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited sh3 shortens snx9 syndapin unlikely wh2	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?