ASAP1 and CRK

Number of citations of the paper that reports this interaction (PMID 9819391)
44

Data Source:
BioGRID (pull down, affinity chromatography technology)

		ASAP1	CRK
Gene Name		ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	v-crk avian sarcoma virus CT10 oncogene homolog
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding ARF GTPase Activator Activity Zinc Ion Binding	SH3/SH2 Adaptor Activity Protein Binding SH2 Domain Binding Protein Phosphorylated Amino Acid Binding Ephrin Receptor Binding
	Biological Process	Organelle Organization Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Cilium Morphogenesis	Activation Of MAPKK Activity Regulation Of Transcription From RNA Polymerase II Promoter Blood Coagulation Insulin Receptor Signaling Pathway Platelet Activation Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Rac Protein Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance VxPx cargo-targeting to cilium Assembly of the primary cilium	Signalling to ERKs Prolonged ERK activation events Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway Regulation of signaling by CBL Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Signaling by Insulin receptor Innate Immune System Signaling by PDGF Signalling by NGF Insulin receptor signalling cascade p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane ARMS-mediated activation Signaling by Interleukins Signal attenuation Signaling by VEGF Downstream signal transduction Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS		Multiple sclerosis ( 19525955)
Protein-Protein Interactions		13 interactors: ARF1 CBL CRK GRB2 HCK IKBKG PACSIN3 PTK2 PTK2B PXN REPS2 SH3KBP1 SRC	84 interactors: ABL1 ABL2 ARHGAP17 ARHGAP32 ASAP1 ATXN1 AVIL BCAR1 BCR BUB1 CBL CBLC CRKL DAB1 DOCK1 DOCK3 DOK1 DOK4 DPPA4 EFS EGFR EPHA3 EPHB2 EPHB3 EPHB6 EPS15 ERBB2 ERBB3 ERBB4 FAM154A FASLG FGFR1 FLT1 FRS2 FYN GAB1 GRB2 IGF1R INSR IRS1 IRS2 IRS4 KDR KHDRBS1 KIT MAP4K1 MAP4K5 MAPK4 MAPK8 MICAL1 NCK1 NEDD9 NTRK1 PDGFRA PDGFRB PIK3R1 PLSCR1 POT1 PPFIBP2 PPP1CA PSMC6 PTK2 PTK2B PTPN1 PTPN4 PXN RAPGEF1 REPS1 RET SH3BP1 SHB SHC1 SOCS1 SOS1 SPRR2A STAT5A STAT5B SYN1 TERF2IP VAV1 WASF1 WEE1 XPO1 ZAP70
Entrez ID		50807	1398
HPRD ID		05809	01267
Ensembl ID		ENSG00000153317	ENSG00000167193
Uniprot IDs		Q9ULH1	L7RT18 P46108
PDB IDs		2D1X 2DA0 2ED1 2RQT 2RQU	1JU5 2DVJ 2EYV 2EYW 2EYX 2EYY 2EYZ
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Complex Assembly Regulation Of Cellular Component Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cell Surface Receptor Signaling Pathway Regulation Of Cell Shape Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Endocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Endocytosis Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Response To Peptide Hormone Positive Regulation Of Protein Kinase Activity Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Positive Regulation Of Kinase Activity Response To Peptide Regulation Of Cytoskeleton Organization Signal Transduction Positive Regulation Of Immune System Process Regulation Of Organelle Organization Phagocytosis Vesicle-mediated Transport Peptidyl-tyrosine Phosphorylation Activation Of Protein Kinase Activity Response To Hormone Positive Regulation Of Transferase Activity Regulation Of Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Signaling Response To Growth Factor Cell Communication Regulation Of MAPK Cascade	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signaling ERBB Signaling Pathway Regulation Of Signal Transduction Signaling Positive Regulation Of Signal Transduction Signal Transduction Cell Communication Cell Surface Receptor Signaling Pathway Response To Growth Factor Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Catalytic Activity Protein Autophosphorylation Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Response To Stimulus Cellular Response To Organonitrogen Compound Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Response To Organic Substance Phosphatidylinositol-mediated Signaling Regulation Of Immune Response Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Peptidyl-amino Acid Modification Immune Response-regulating Signaling Pathway Response To Fibroblast Growth Factor Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Cellular Response To Peptide Hormone Stimulus Regulation Of MAPK Cascade Immune System Process Positive Regulation Of Transferase Activity Phosphorylation Cellular Response To Peptide Positive Regulation Of MAPK Cascade Fc-epsilon Receptor Signaling Pathway Innate Immune Response
Tagcloud ?		actin apical associate bar basal base believed bleu cobl cordon curved ectopic localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited sh3 shortens snx9 syndapin unlikely wh2	abundantly adhesions arises associating carboxy cas conferring connect coordinating dim1p efs encompassed encompasses fyn hef1 identifies interactor localize multidomain oncoproteins p105 p115 p130 p55 sh3 sin spindle sum unexpectedly
Tagcloud (Difference) ?		actin apical associate bar basal base believed bleu cobl cordon curved ectopic localization localized microvillar microvilli nucleation nucleator pacsin participate proteomic recruit recruited shortens snx9 syndapin unlikely wh2	abundantly adhesions arises associating carboxy cas conferring connect coordinating dim1p efs encompassed encompasses fyn hef1 identifies interactor localize multidomain oncoproteins p105 p115 p130 p55 sin spindle sum unexpectedly
Tagcloud (Intersection) ?		sh3