ORM1 and PIK3R3

Number of citations of the paper that reports this interaction (PMID 18624398)
4

Data Source:
BioGRID (two hybrid)

		ORM1	PIK3R3
Gene Name		orosomucoid 1	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome Blood Microparticle	Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Protein Binding	Protein Binding 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Regulator Activity
	Biological Process	Regulation Of Immune System Process Transport Acute-phase Response Inflammatory Response	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Insulin Receptor Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase Activity Small Molecule Metabolic Process
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Interleukin receptor SHC signaling PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Interleukin-7 signaling Phospholipid metabolism Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR Signaling by Interleukins GPCR downstream signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System G alpha (q) signalling events Costimulation by the CD28 family PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR G alpha (12/13) signalling events PI Metabolism Innate Immune System Signalling by NGF Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR GPVI-mediated activation cascade Interleukin receptor SHC signaling
Drugs
Diseases
GWAS		End-stage coagulation ( 23381943) Tourette syndrome ( 22889924)
Protein-Protein Interactions		9 interactors: ALB BLVRB CCR5 GLUD1 GSDMB PIK3R3 SERPINE1 TMEM37 TP63	38 interactors: ABCB6 AMBP AXL DARS DRAP1 DSN1 EGFR ERBB2 ERBB3 ESR1 FBN3 FGB FSD2 GC IGF1R INSR IRS1 IRS2 KARS KHDRBS1 KIAA1377 KLC2 L3MBTL3 LUC7L2 MBIP MICAL1 ORM1 PDGFRB PIK3CA PSME1 QARS RB1 RING1 SERF1A TEC TRIM54 TRMT2A VBP1
Entrez ID		5004	8503
HPRD ID		00724	05831
Ensembl ID		ENSG00000229314	ENSG00000117461
Uniprot IDs		P02763	F6TDL0 Q8N381 Q92569
PDB IDs		3KQ0
Enriched GO Terms of Interacting Partners?		Platelet Degranulation Cell Aging Negative Regulation Of Vascular Wound Healing Epidermal Cell Division Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Ectoderm And Mesoderm Interaction Interaction With Host Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Maintenance Of Mitochondrion Location Regulation Of Body Fluid Levels Positive Regulation Of Behavior Regulation Of Smooth Muscle Cell-matrix Adhesion Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Epidermal Cell Division Chronological Cell Aging Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Regulation Of Vascular Wound Healing Female Genitalia Morphogenesis Cloacal Septation Urinary Bladder Development Regulation Of Behavior Platelet Activation Positive Regulation Of Fibroblast Apoptotic Process Prostatic Bud Formation Cloaca Development Glutamate Catabolic Process Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Mesoderm Development Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Keratinocyte Proliferation Negative Regulation Of Plasminogen Activation Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Heme Catabolic Process Polarized Epithelial Cell Differentiation Negative Regulation Of Apoptotic Process Glutamate Biosynthetic Process Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Programmed Cell Death Negative Regulation Of Cellular Senescence Lateral Sprouting From An Epithelium Replicative Cell Aging Negative Regulation Of Cell Death Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Fibrinolysis Positive Regulation Of Monocyte Chemotaxis Sarcoplasmic Reticulum Calcium Ion Transport	Phosphatidylinositol-mediated Signaling Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Innate Immune Response Immune System Process Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase Signaling Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Hormone Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Negative Regulation Of Cell Death Cellular Response To Hormone Stimulus Positive Regulation Of Signal Transduction Wound Healing Positive Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Defense Response Organ Development Negative Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Regulation Of Signaling Response To Wounding Protein Autophosphorylation Regulation Of Apoptotic Process Regulation Of Signal Transduction Negative Regulation Of Signaling Peptidyl-amino Acid Modification
Tagcloud ?		3t3 a4 adipocytes antioxidants cyclic cytoprotection dismutase endoplasmic ern1 fabp4 glutathione gmp gsh gsta4 h2o2 kinds l1 lowering nitro ormdl3 peroxide reticulum scavenger sod spliced ssr1 superoxide transferase xbp1s	akt carcinogenesis diagnostic downregulated elucidating hcc hepatocellular insights invasion inversely investigations lead malignancy markedly micrornas migration mir mirnas mtor negatively phosphoinositide regulating repressing strategies suppressed suppression taken tissues underlying
Tagcloud (Difference) ?		3t3 a4 adipocytes antioxidants cyclic cytoprotection dismutase endoplasmic ern1 fabp4 glutathione gmp gsh gsta4 h2o2 kinds l1 lowering nitro ormdl3 peroxide reticulum scavenger sod spliced ssr1 superoxide transferase xbp1s	akt carcinogenesis diagnostic downregulated elucidating hcc hepatocellular insights invasion inversely investigations lead malignancy markedly micrornas migration mir mirnas mtor negatively phosphoinositide regulating repressing strategies suppressed suppression taken tissues underlying
Tagcloud (Intersection) ?