PIK3R3 and ERBB3

Number of citations of the paper that reports this interaction (PMID 16273093)
170

Data Source:
BioGRID (unspecified method)

		PIK3R3	ERBB3
Gene Name		phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	erb-b2 receptor tyrosine kinase 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Phosphatidylinositol 3-kinase Complex	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Receptor Complex
	Molecular Function	Protein Binding 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Regulator Activity	Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Insulin Receptor Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase Activity Small Molecule Metabolic Process	Endocardial Cushion Development Protein Phosphorylation Negative Regulation Of Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Peripheral Nervous System Development Heart Development Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Signal Transduction Schwann Cell Differentiation Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cranial Nerve Development Fc-epsilon Receptor Signaling Pathway Wound Healing Regulation Of Cell Proliferation Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Secretion Neuron Apoptotic Process Positive Regulation Of Protein Tyrosine Kinase Activity Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Interleukin receptor SHC signaling PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Interleukin-7 signaling Phospholipid metabolism Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR Signaling by Interleukins GPCR downstream signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System G alpha (q) signalling events Costimulation by the CD28 family PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR G alpha (12/13) signalling events PI Metabolism Innate Immune System Signalling by NGF Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR GPVI-mediated activation cascade Interleukin receptor SHC signaling
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Type 1 diabetes ( 19430480 18198356 17554260 17554300 18978792) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 22951725)
Protein-Protein Interactions		38 interactors: ABCB6 AMBP AXL DARS DRAP1 DSN1 EGFR ERBB2 ERBB3 ESR1 FBN3 FGB FSD2 GC IGF1R INSR IRS1 IRS2 KARS KHDRBS1 KIAA1377 KLC2 L3MBTL3 LUC7L2 MBIP MICAL1 ORM1 PDGFRB PIK3CA PSME1 QARS RB1 RING1 SERF1A TEC TRIM54 TRMT2A VBP1	66 interactors: ABL1 ABL2 AGTR2 BCAR3 CD82 CDK5 CHN2 CRK CRKL DAB1 DAPP1 EGF EGFR EGR1 ERBB2 ERBB4 FER FGFR1 FLNA FLYWCH1 GRB2 GRB7 HCK HDAC6 IL6ST ITK JAK2 JAK3 MUC1 NCK1 NCK2 NEDD4 NRG1 NRG2 ODF2L PA2G4 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTGES3 PTK2 PTK2B PTK6 RASA1 RASA4 RGS4 RIN1 RNF41 RPN1 SH2B3 SH2D1A SHC1 SHC3 SOS1 SRC SYK TNS2 TNS3 TNS4 TXK VAV1 VAV2 VAV3 ZAP70 ZNF207
Entrez ID		8503	2065
HPRD ID		05831	01820
Ensembl ID		ENSG00000117461	ENSG00000065361
Uniprot IDs		F6TDL0 Q8N381 Q92569	P21860
PDB IDs			1M6B 2L9U 3KEX 3LMG 3P11 4LEO
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-mediated Signaling Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Innate Immune Response Immune System Process Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase Signaling Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Hormone Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Negative Regulation Of Cell Death Cellular Response To Hormone Stimulus Positive Regulation Of Signal Transduction Wound Healing Positive Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Defense Response Organ Development Negative Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Regulation Of Signaling Response To Wounding Protein Autophosphorylation Regulation Of Apoptotic Process Regulation Of Signal Transduction Negative Regulation Of Signaling Peptidyl-amino Acid Modification	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Cell Communication Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Signaling Regulation Of Signaling Cell Migration Signal Transduction Immune Response Regulation Of Immune Response Peptidyl-tyrosine Autophosphorylation Cell Motility Locomotion Positive Regulation Of Signal Transduction Regulation Of Immune System Process Intracellular Signal Transduction Defense Response Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Immune System Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Cellular Response To Stimulus Regulation Of Kinase Activity Regulation Of Catalytic Activity Fc-epsilon Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Cell Activation Response To Growth Factor Response To Stress Positive Regulation Of Catalytic Activity Response To Stimulus Wound Healing Response To Organic Substance Cellular Response To Growth Factor Stimulus Regulation Of Cell Proliferation Blood Coagulation Hemostasis
Tagcloud ?		akt carcinogenesis diagnostic downregulated elucidating hcc hepatocellular insights invasion inversely investigations lead malignancy markedly micrornas migration mir mirnas mtor negatively phosphoinositide regulating repressing strategies suppressed suppression taken tissues underlying	acquire alteration associate cascades concurrent dependence egf enhancing latent mapk mediators p42 p44 phosphotyrosine potentiates potentiating predicts prime priming progestin progestins r5020 shc shift stat5 steroid switches synergistically waf1
Tagcloud (Difference) ?		akt carcinogenesis diagnostic downregulated elucidating hcc hepatocellular insights invasion inversely investigations lead malignancy markedly micrornas migration mir mirnas mtor negatively phosphoinositide regulating repressing strategies suppressed suppression taken tissues underlying	acquire alteration associate cascades concurrent dependence egf enhancing latent mapk mediators p42 p44 phosphotyrosine potentiates potentiating predicts prime priming progestin progestins r5020 shc shift stat5 steroid switches synergistically waf1
Tagcloud (Intersection) ?