NPPC and NPR3

Number of citations of the paper that reports this interaction (PMID 1672777)
65

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		NPPC	NPR3
Gene Name		natriuretic peptide C	natriuretic peptide receptor 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Secretory Granule	Integral Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Hormone Activity Protein Homodimerization Activity Peptide Hormone Receptor Binding	G-protein Coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Hormone Binding Protein Homodimerization Activity
	Biological Process	Ossification Response To Hypoxia Growth Plate Cartilage Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Proliferation CGMP Biosynthetic Process Receptor Guanylyl Cyclase Signaling Pathway Negative Regulation Of Cell Proliferation Post-embryonic Development Regulation Of CAMP Metabolic Process Regulation Of CGMP Metabolic Process Positive Regulation Of CGMP Biosynthetic Process Regulation Of Multicellular Organism Growth Response To Drug Single Organism Reproductive Process Response To Ethanol Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Vasodilation Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Vessel Size Negative Regulation Of DNA Metabolic Process Negative Regulation Of Meiotic Cell Cycle Negative Regulation Of Oocyte Maturation	Skeletal System Development Osteoclast Proliferation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Blood Pressure Pancreatic Juice Secretion Regulation Of Osteoblast Proliferation Positive Regulation Of Urine Volume Phosphatidylinositol-mediated Signaling Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Nitric-oxide Synthase Activity
Pathways
Drugs
Diseases
GWAS		Height ( 20881960 19570815 18391951)	Blood pressure ( 21572416 21909110) Diastolic blood pressure ( 21909115) Height ( 20881960 19343178 23563607 19570815) Hypertension ( 21909115) Ovarian reserve ( 22116950) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		4 interactors: MME NPR1 NPR2 NPR3	3 interactors: NPPA NPPB NPPC
Entrez ID		4880	4883
HPRD ID		08975	00167
Ensembl ID			ENSG00000113389
Uniprot IDs		E5LCN7 P23582	A8K4A5 C9JK69 P17342 Q60I31
PDB IDs		1JDP	1JDN 1JDP 1YK0 1YK1
Enriched GO Terms of Interacting Partners?		Regulation Of Blood Pressure Blood Circulation Receptor Guanylyl Cyclase Signaling Pathway Positive Regulation Of Urine Volume CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Cyclic Nucleotide Biosynthetic Process Cyclic Nucleotide Metabolic Process Renal System Process Regulation Of Smooth Muscle Cell Proliferation Body Fluid Secretion Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Cellular Response To UV-A Negative Regulation Of Oocyte Maturation Negative Regulation Of Oocyte Development Osteoclast Proliferation Creatinine Metabolic Process Ribonucleotide Metabolic Process Response To UV-A Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Pancreatic Juice Secretion Cellular Response To UV-B Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Angiotensin Maturation Intracellular Signal Transduction Regulation Of Angiotensin Metabolic Process Positive Regulation Of Renal Sodium Excretion Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Response To UV-B Replicative Senescence Positive Regulation Of CGMP Biosynthetic Process Positive Regulation Of Nitric-oxide Synthase Activity Beta-amyloid Metabolic Process Positive Regulation Of CGMP Metabolic Process Skeletal System Development Nucleotide Metabolic Process Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus Small Molecule Metabolic Process Regulation Of Renal Sodium Excretion Negative Regulation Of Adenylate Cyclase Activity Regulation Of CGMP Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Negative Regulation Of Lyase Activity Regulation Of Osteoblast Proliferation	Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Cyclic Nucleotide Biosynthetic Process Regulation Of Blood Vessel Size Regulation Of Tube Size Cyclic Nucleotide Metabolic Process Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Blood Circulation Ribose Phosphate Metabolic Process Regulation Of Vasodilation Nucleotide Metabolic Process Regulation Of Growth Nucleobase-containing Small Molecule Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Organophosphate Metabolic Process Negative Regulation Of Cell Growth Regulation Of Blood Pressure Growth Plate Cartilage Chondrocyte Proliferation Negative Regulation Of Growth Negative Regulation Of Oocyte Maturation Response To Hypoxia Regulation Of Generation Of L-type Calcium Current Positive Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Oocyte Development Regulation Of Cell Growth Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Cardiac Muscle Contraction Growth Plate Cartilage Chondrocyte Differentiation Small Molecule Metabolic Process Regulation Of Delayed Rectifier Potassium Channel Activity Response To Muscle Stretch Positive Regulation Of Striated Muscle Contraction Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Renal Sodium Excretion Phosphate-containing Compound Metabolic Process Positive Regulation Of Urine Volume Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of CGMP Biosynthetic Process Cardiac Muscle Hypertrophy In Response To Stress Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Cell Surface Receptor Signaling Pathway Positive Regulation Of CGMP Metabolic Process Growth Plate Cartilage Development
Tagcloud ?			atherogenic cip1 cnp cytoprotective exerting facet gpcrs huvec innovative ischaemic kip1 ko m372049 mitogenesis myocardium natriuretic pd98059 pertussis raosmc reversing salvaging smooth umbilical underlies vasculature vasoprotective vasorelaxant waf1
Tagcloud (Difference) ?			atherogenic cip1 cnp cytoprotective exerting facet gpcrs huvec innovative ischaemic kip1 ko m372049 mitogenesis myocardium natriuretic pd98059 pertussis raosmc reversing salvaging smooth umbilical underlies vasculature vasoprotective vasorelaxant waf1
Tagcloud (Intersection) ?