NME2 and HERC5

Number of citations of the paper that reports this interaction (PMID 18535780)
6

Data Source:
HPRD (in vivo)

		NME2	HERC5
Gene Name		NME/NM23 nucleoside diphosphate kinase 2	HECT and RLD domain containing E3 ubiquitin protein ligase 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Intermediate Filament Focal Adhesion Membrane Lamellipodium Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cell Periphery	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Binding ATP Binding Intermediate Filament Binding Protein Kinase Binding Gamma-tubulin Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity ISG15 Transferase Activity Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Myeloid Leukocyte Differentiation Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Adhesion Integrin-mediated Signaling Pathway Nucleoside Triphosphate Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Amine Nucleobase-containing Small Molecule Interconversion Peptidyl-histidine Phosphorylation Hippocampus Development Response To Testosterone Cellular Response To Drug Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Keratinocyte Differentiation Regulation Of Epidermis Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial Cell Proliferation Response To CAMP Nucleobase-containing Small Molecule Metabolic Process Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cytokine-mediated Signaling Pathway ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Defense Response To Virus Defense Response To Virus
Pathways		Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Innate Immune System
Drugs
Diseases
GWAS		Height ( 20881960)	Pulmonary function decline ( 22424883)
Protein-Protein Interactions		20 interactors: BNIPL CTBP1 DNM1 GIT2 HERC3 HERC5 HERC6 MOB4 NME1 NME1-NME2 NME3 NME4 PPP2CA RAB5A RORA RORB SVIL TBXA2R TERF1 VIM	10 interactors: CCNA2 CCNB1 CCND1 CCNE1 CDKN1A ERCC2 NME2 PITX2 STK38 UBE2D1
Entrez ID		4831	51191
HPRD ID		01132	10502
Ensembl ID		ENSG00000243678	ENSG00000138646
Uniprot IDs		P22392 Q6FHN3	B4DXV3 E9PBL0 Q9UII4
PDB IDs		1NSK 1NUE 3BBB 3BBC 3BBF
Enriched GO Terms of Interacting Partners?		GTP Biosynthetic Process UTP Biosynthetic Process GTP Metabolic Process UTP Metabolic Process CTP Biosynthetic Process Nucleoside Diphosphate Phosphorylation Pyrimidine Ribonucleotide Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nucleotide Phosphorylation Nucleoside Diphosphate Metabolic Process Pyrimidine Nucleoside Metabolic Process Pyrimidine Nucleotide Metabolic Process Nucleoside Triphosphate Biosynthetic Process Ribonucleotide Metabolic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Purine Nucleoside Metabolic Process Nucleotide Metabolic Process Nucleobase-containing Small Molecule Interconversion Nucleoside Metabolic Process Nucleotide Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Negative Regulation Of Cell Differentiation Cellular Macromolecule Catabolic Process Receptor Internalization Thromboxane A2 Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Organophosphate Metabolic Process Regulation Of Cellular Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Developmental Process Receptor Metabolic Process Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Regulation Of Growth Rate Telomeric Loop Formation Age-dependent Telomere Shortening Negative Regulation Of Chromosome Organization Regulation Of Circadian Rhythm Cerebellar Granule Cell Precursor Proliferation Telomere Maintenance Via Telomere Shortening Steroid Hormone Mediated Signaling Pathway Regulation Of Cellular Component Organization Cell Differentiation Cell Proliferation In Hindbrain Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein	Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic Cell Cycle Process Regulation Of Protein Kinase Activity Negative Regulation Of Gene Expression Protein Phosphorylation Mitotic Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Cell Proliferation G1/S Transition Of Mitotic Cell Cycle Response To Lipid Cell Division Mitotic Cell Cycle Checkpoint Cell Cycle Process Regulation Of Protein Phosphorylation Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Phosphorylation Positive Regulation Of Fibroblast Proliferation Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Organ Regeneration Cellular Protein Modification Process Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Cell Cycle Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Mitotic DNA Damage Checkpoint Regulation Of Fibroblast Proliferation Mitotic DNA Integrity Checkpoint Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Regulation Of Metabolic Process Cellular Response To Stress Positive Regulation Of Gene Expression Response To Organic Substance G2/M Transition Of Mitotic Cell Cycle Response To Organic Cyclic Compound Response To UV Response To Hormone
Tagcloud ?		17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme1 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3	accumulation alternative attractive deletion drugs enhancing inactivation involving isg15 isgylation multistep native oncogene oncogenes p53 promoting propose regulate src stability suppressing suppressor suppressors transformation transformed tumorigenesis turn tyr126 tyr220
Tagcloud (Difference) ?		17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme1 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3	accumulation alternative attractive deletion drugs enhancing inactivation involving isg15 isgylation multistep native oncogene oncogenes p53 promoting propose regulate src stability suppressing suppressor suppressors transformation transformed tumorigenesis turn tyr126 tyr220
Tagcloud (Intersection) ?