NME2 and NME4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NME2	NME4
Gene Name		NME/NM23 nucleoside diphosphate kinase 2	NME/NM23 nucleoside diphosphate kinase 4
Image
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Intermediate Filament Focal Adhesion Membrane Lamellipodium Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cell Periphery	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Binding ATP Binding Intermediate Filament Binding Protein Kinase Binding Gamma-tubulin Binding Metal Ion Binding	Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding Protein Complex Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Myeloid Leukocyte Differentiation Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Adhesion Integrin-mediated Signaling Pathway Nucleoside Triphosphate Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Amine Nucleobase-containing Small Molecule Interconversion Peptidyl-histidine Phosphorylation Hippocampus Development Response To Testosterone Cellular Response To Drug Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Keratinocyte Differentiation Regulation Of Epidermis Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial Cell Proliferation Response To CAMP Nucleobase-containing Small Molecule Metabolic Process Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid	Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process Nucleoside Metabolic Process Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Regulation Of Apoptotic Process Small Molecule Metabolic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways		Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates	Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS		Height ( 20881960)	Red blood cell traits ( 23446634)
Protein-Protein Interactions		20 interactors: BNIPL CTBP1 DNM1 GIT2 HERC3 HERC5 HERC6 MOB4 NME1 NME1-NME2 NME3 NME4 PPP2CA RAB5A RORA RORB SVIL TBXA2R TERF1 VIM	7 interactors: LSM8 NME1 NME1-NME2 NME2 SOCS3 SUV39H2 TRIP13
Entrez ID		4831	4833
HPRD ID		01132	03489
Ensembl ID		ENSG00000243678	ENSG00000103202
Uniprot IDs		P22392 Q6FHN3	A2IDD0 O00746
PDB IDs		1NSK 1NUE 3BBB 3BBC 3BBF	1EHW
Enriched GO Terms of Interacting Partners?		GTP Biosynthetic Process UTP Biosynthetic Process GTP Metabolic Process UTP Metabolic Process CTP Biosynthetic Process Nucleoside Diphosphate Phosphorylation Pyrimidine Ribonucleotide Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nucleotide Phosphorylation Nucleoside Diphosphate Metabolic Process Pyrimidine Nucleoside Metabolic Process Pyrimidine Nucleotide Metabolic Process Nucleoside Triphosphate Biosynthetic Process Ribonucleotide Metabolic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Purine Nucleoside Metabolic Process Nucleotide Metabolic Process Nucleobase-containing Small Molecule Interconversion Nucleoside Metabolic Process Nucleotide Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Negative Regulation Of Cell Differentiation Cellular Macromolecule Catabolic Process Receptor Internalization Thromboxane A2 Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Organophosphate Metabolic Process Regulation Of Cellular Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Developmental Process Receptor Metabolic Process Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Regulation Of Growth Rate Telomeric Loop Formation Age-dependent Telomere Shortening Negative Regulation Of Chromosome Organization Regulation Of Circadian Rhythm Cerebellar Granule Cell Precursor Proliferation Telomere Maintenance Via Telomere Shortening Steroid Hormone Mediated Signaling Pathway Regulation Of Cellular Component Organization Cell Differentiation Cell Proliferation In Hindbrain Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein	GTP Biosynthetic Process UTP Biosynthetic Process GTP Metabolic Process UTP Metabolic Process CTP Biosynthetic Process Nucleoside Diphosphate Phosphorylation Pyrimidine Ribonucleotide Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nucleotide Phosphorylation Nucleoside Diphosphate Metabolic Process Pyrimidine Nucleoside Metabolic Process Pyrimidine Nucleotide Metabolic Process Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Purine Nucleoside Metabolic Process Response To Testosterone Cell Differentiation Ribonucleotide Metabolic Process Nucleoside Metabolic Process Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Cellular Response To Fatty Acid Ribose Phosphate Metabolic Process Response To Amine Negative Regulation Of Myeloid Leukocyte Differentiation Cellular Response To Drug Male Meiosis Cellular Response To Glucose Stimulus Response To Fatty Acid Hippocampus Development Cellular Glucose Homeostasis Cellular Response To Carbohydrate Stimulus Negative Regulation Of Myeloid Cell Differentiation Nucleobase-containing Compound Metabolic Process Limbic System Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleotide Metabolic Process Regulation Of Myeloid Leukocyte Differentiation Cellular Nitrogen Compound Metabolic Process Response To CAMP Response To Glucose Nucleobase-containing Small Molecule Metabolic Process Response To Organophosphorus Positive Regulation Of Epithelial Cell Proliferation Developmental Process Nitrogen Compound Metabolic Process
Tagcloud ?		17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme1 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3	5q aml analysed array arrays blast cdna cluster comprising de differently ercc1 flt1 larger myelodysplastic novo pcna probes profiles progressive qrt raeb rcmd represents subtypes transformation unfavorable validated whose
Tagcloud (Difference) ?		17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme1 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3	5q aml analysed array arrays blast cdna cluster comprising de differently ercc1 flt1 larger myelodysplastic novo pcna probes profiles progressive qrt raeb rcmd represents subtypes transformation unfavorable validated whose
Tagcloud (Intersection) ?