NME2 and NME3

Number of citations of the paper that reports this interaction (PMID 11042679)
5

Data Source:
HPRD (in vivo)

		NME2	NME3
Gene Name		NME/NM23 nucleoside diphosphate kinase 2	NME/NM23 nucleoside diphosphate kinase 3
Image
Gene Ontology Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Intermediate Filament Focal Adhesion Membrane Lamellipodium Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cell Periphery	Mitochondrion Cytosol Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Single-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Binding ATP Binding Intermediate Filament Binding Protein Kinase Binding Gamma-tubulin Binding Metal Ion Binding	Nucleoside Diphosphate Kinase Activity ATP Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Myeloid Leukocyte Differentiation Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Adhesion Integrin-mediated Signaling Pathway Nucleoside Triphosphate Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Amine Nucleobase-containing Small Molecule Interconversion Peptidyl-histidine Phosphorylation Hippocampus Development Response To Testosterone Cellular Response To Drug Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Keratinocyte Differentiation Regulation Of Epidermis Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial Cell Proliferation Response To CAMP Nucleobase-containing Small Molecule Metabolic Process Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid	Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process Apoptotic Process Nucleoside Triphosphate Biosynthetic Process Regulation Of Apoptotic Process
Pathways		Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS		Height ( 20881960)
Protein-Protein Interactions		20 interactors: BNIPL CTBP1 DNM1 GIT2 HERC3 HERC5 HERC6 MOB4 NME1 NME1-NME2 NME3 NME4 PPP2CA RAB5A RORA RORB SVIL TBXA2R TERF1 VIM	8 interactors: APP HTR2A JAM2 NME1 NME2 SGTA UBQLN1 UBQLN4
Entrez ID		4831	4832
HPRD ID		01132	03488
Ensembl ID		ENSG00000243678	ENSG00000103024
Uniprot IDs		P22392 Q6FHN3	Q13232
PDB IDs		1NSK 1NUE 3BBB 3BBC 3BBF	1ZS6
Enriched GO Terms of Interacting Partners?		GTP Biosynthetic Process UTP Biosynthetic Process GTP Metabolic Process UTP Metabolic Process CTP Biosynthetic Process Nucleoside Diphosphate Phosphorylation Pyrimidine Ribonucleotide Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nucleotide Phosphorylation Nucleoside Diphosphate Metabolic Process Pyrimidine Nucleoside Metabolic Process Pyrimidine Nucleotide Metabolic Process Nucleoside Triphosphate Biosynthetic Process Ribonucleotide Metabolic Process Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Purine Nucleoside Metabolic Process Nucleotide Metabolic Process Nucleobase-containing Small Molecule Interconversion Nucleoside Metabolic Process Nucleotide Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Negative Regulation Of Cell Differentiation Cellular Macromolecule Catabolic Process Receptor Internalization Thromboxane A2 Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Organophosphate Metabolic Process Regulation Of Cellular Process Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Developmental Process Receptor Metabolic Process Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Regulation Of Growth Rate Telomeric Loop Formation Age-dependent Telomere Shortening Negative Regulation Of Chromosome Organization Regulation Of Circadian Rhythm Cerebellar Granule Cell Precursor Proliferation Telomere Maintenance Via Telomere Shortening Steroid Hormone Mediated Signaling Pathway Regulation Of Cellular Component Organization Cell Differentiation Cell Proliferation In Hindbrain Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein	Nucleobase-containing Small Molecule Interconversion GTP Biosynthetic Process UTP Biosynthetic Process GTP Metabolic Process UTP Metabolic Process CTP Biosynthetic Process Nucleoside Diphosphate Phosphorylation Pyrimidine Ribonucleotide Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nucleotide Phosphorylation Nucleoside Diphosphate Metabolic Process Pyrimidine Nucleoside Metabolic Process Pyrimidine Nucleotide Metabolic Process Nucleoside Triphosphate Biosynthetic Process Cellular Chemical Homeostasis Phospholipase C-activating Serotonin Receptor Signaling Pathway Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Positive Regulation Of Epithelial Cell Proliferation Cellular Homeostasis Positive Regulation Of Phosphatidylinositol Biosynthetic Process Purine Nucleotide Biosynthetic Process Adult Behavior Ribose Phosphate Biosynthetic Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Cell Proliferation Regulation Of Peptidyl-tyrosine Phosphorylation Axon Choice Point Recognition Chemical Homeostasis Regulation Of Cellular Protein Metabolic Process Artery Smooth Muscle Contraction Purine Nucleoside Metabolic Process Tonic Smooth Muscle Contraction Neuron Remodeling Regulation Of Binding Learning Or Memory Urinary Bladder Smooth Muscle Contraction Peptidyl-histidine Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Epithelial Cell Proliferation Cognition Ribonucleotide Metabolic Process Nucleoside Metabolic Process Cellular Calcium Ion Homeostasis Nucleotide Biosynthetic Process Positive Regulation Of Glycolytic Process
Tagcloud ?		17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme1 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3	address affecting arhgdib autonomous bcl3 concomitant deregulated dissociation erbb2 gdp intrinsic lungs malignancy mammary metalloprotease mmtv modifying motility neu nme1 nme2 oncogene oncogenic proto rescued solid timp1 timp2 turnover
Tagcloud (Difference) ?		17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3	address affecting arhgdib autonomous bcl3 concomitant deregulated dissociation erbb2 gdp intrinsic lungs malignancy mammary metalloprotease mmtv modifying motility neu oncogene oncogenic proto rescued solid timp1 timp2 turnover
Tagcloud (Intersection) ?		nme1 nme2