PPP1R12A and DMPK

Number of citations of the paper that reports this interaction (PMID 10601309)
113

Data Source:
HPRD (in vitro)

		PPP1R12A	DMPK
Gene Name		protein phosphatase 1, regulatory subunit 12A	dystrophia myotonica-protein kinase
Image
Gene Ontology Annotations	Cellular Component	Kinetochore Nucleoplasm Cytoplasm Centrosome Focal Adhesion Actin Cytoskeleton Contractile Fiber PTW/PP1 Phosphatase Complex	Nuclear Outer Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Mitochondrial Outer Membrane Nuclear Membrane Sarcoplasmic Reticulum Membrane
	Molecular Function	Enzyme Inhibitor Activity Signal Transducer Activity Protein Binding Phosphatase Regulator Activity Protein Kinase Binding 14-3-3 Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Myosin Phosphatase Regulator Activity Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Dephosphorylation Mitotic Nuclear Division Signal Transduction Regulation Of Cell Adhesion Regulation Of Myosin-light-chain-phosphatase Activity Negative Regulation Of Catalytic Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleocytoplasmic Transport Centrosome Organization	Protein Phosphorylation Cellular Calcium Ion Homeostasis Nuclear Envelope Organization Regulation Of Heart Contraction Muscle Cell Apoptotic Process Regulation Of Myotube Differentiation Regulation Of Catalytic Activity
Pathways		G2/M Transition Mitotic G2-G2/M phases Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		12 interactors: ATXN10 DMPK IL16 ILK KDM1A MPRIP PRKG1 RHOA ROCK1 ROCK2 SETD7 YWHAG	18 interactors: ANXA7 ATN1 ATXN1 CELF1 FXYD1 GABARAP GEMIN4 HOXA2 HSPB2 PIN1 PLN PPP1R12A RAC1 RAF1 RPS10 SMN1 TK1 UBQLN4
Entrez ID		4659	1760
HPRD ID		03606	05645
Ensembl ID		ENSG00000058272	ENSG00000104936
Uniprot IDs		B2RAH5 O14974	E5KR05 E5KR06 E5KR07 E5KR08 M0R333 Q09013
PDB IDs		2KJY	1WT6 2VD5
Enriched GO Terms of Interacting Partners?		Neuron Projection Development Nervous System Development Regulation Of Organelle Organization Generation Of Neurons Regulation Of Cell Differentiation Neuron Development Rho Protein Signal Transduction Neurogenesis Regulation Of Stress Fiber Assembly Cell Development Neuron Differentiation Cell Projection Organization Regulation Of Locomotion Locomotion Ephrin Receptor Signaling Pathway Organelle Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-matrix Adhesion Cell Differentiation Cell Migration Movement Of Cell Or Subcellular Component Regulation Of Actin Filament-based Process Blood Coagulation Cell Motility Hemostasis Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Keratinocyte Differentiation Regulation Of Cell-substrate Adhesion System Development Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Wound Healing Chemotaxis Ras Protein Signal Transduction Actin Cytoskeleton Organization Regulation Of Establishment Of Cell Polarity Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Establishment Or Maintenance Of Cell Polarity Neuron Projection Morphogenesis Actin Filament-based Process Cellular Protein Modification Process Protein Phosphorylation Regulation Of Epidermal Cell Differentiation Regulation Of Cellular Component Movement Muscle System Process Response To Wounding Regulation Of Focal Adhesion Assembly	Regulation Of Cardiac Muscle Cell Membrane Potential Cellular Component Assembly Response To Organic Substance Ribonucleoprotein Complex Assembly Spliceosomal SnRNP Assembly MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Death-inducing Signaling Complex Assembly Fetal Process Involved In Parturition Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Negative Regulation Of Calcium-transporting ATPase Activity Spliceosomal Complex Assembly Anatomical Structure Development Regulation Of Membrane Potential Cellular Macromolecular Complex Assembly Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Cellular Component Movement Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Rhombomere 3 Morphogenesis Rhombomere 2 Development Skeletal Muscle Cell Proliferation Negative Regulation Of Calcium Ion Binding Regulation Of The Force Of Heart Contraction By Cardiac Conduction Ribonucleoprotein Complex Biogenesis Response To Metal Ion Cell Proliferation Regulation Of Rho Protein Signal Transduction RNA Splicing Response To Osmotic Stress Apoptotic Signaling Pathway Regulation Of Metabolic Process Brain Segmentation Engulfment Of Apoptotic Cell Regulation Of Myosin-light-chain-phosphatase Activity Regulation Of Calcium-transporting ATPase Activity Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Gene Expression Vascular Endothelial Growth Factor Receptor Signaling Pathway Developmental Process Axon Guidance Extrinsic Apoptotic Signaling Pathway Mast Cell Chemotaxis Rhombomere 3 Development Positive Regulation Of Sodium Ion Export From Cell G-protein Coupled Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Cellular Metabolic Process
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Tagcloud (Difference) ?			acquire arenas bioanalysis budgets capturing career celltech ei employing exactive graduating introducing joined lloyd momentum oceanography orbitrap pharma projects qc qual quan spent swansea tasked thermospray ucb whilst wyeth
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