DMPK and PLN

Number of citations of the paper that reports this interaction (PMID 15598648)
6

Data Source:
HPRD (in vitro, in vivo)

		DMPK	PLN
Gene Name		dystrophia myotonica-protein kinase	phospholamban
Image
Gene Ontology Annotations	Cellular Component	Nuclear Outer Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Mitochondrial Outer Membrane Nuclear Membrane Sarcoplasmic Reticulum Membrane	Mitochondrion Endoplasmic Reticulum Membrane Mitochondrial Membrane Vesicle Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Calcium Ion-transporting ATPase Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Myosin Phosphatase Regulator Activity Metal Ion Binding	Enzyme Inhibitor Activity Calcium Channel Regulator Activity Protein Binding ATPase Inhibitor Activity Identical Protein Binding ATPase Binding
	Biological Process	Protein Phosphorylation Cellular Calcium Ion Homeostasis Nuclear Envelope Organization Regulation Of Heart Contraction Muscle Cell Apoptotic Process Regulation Of Myotube Differentiation Regulation Of Catalytic Activity	Regulation Of The Force Of Heart Contraction Calcium Ion Transport Blood Circulation Regulation Of Heart Contraction Response To Zinc Ion Negative Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of ATPase Activity Response To Insulin Response To Testosterone Negative Regulation Of Catalytic Activity Cardiac Muscle Tissue Development Protein Homooligomerization Cytosolic Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Relaxation Of Cardiac Muscle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Negative Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Binding Regulation Of Calcium-transporting ATPase Activity Negative Regulation Of Calcium-transporting ATPase Activity Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways			Ion transport by P-type ATPases Ion channel transport
Drugs
Diseases
GWAS			Cardiac structure and function ( 19584346) QT interval ( 23166209 19305408 19305409 19587794) Ventricular conduction ( 21076409)
Protein-Protein Interactions		18 interactors: ANXA7 ATN1 ATXN1 CELF1 FXYD1 GABARAP GEMIN4 HOXA2 HSPB2 PIN1 PLN PPP1R12A RAC1 RAF1 RPS10 SMN1 TK1 UBQLN4	11 interactors: ATP2A1 ATP2A2 DMPK DVL3 EDA LDLRAD1 PPP1R3A PRKACA S100A1 SLN TMEM79
Entrez ID		1760	5350
HPRD ID		05645	01395
Ensembl ID		ENSG00000104936	ENSG00000198523
Uniprot IDs		E5KR05 E5KR06 E5KR07 E5KR08 M0R333 Q09013	P26678 Q5R352
PDB IDs		1WT6 2VD5	1K9N 1KCH 1PLN 1PLP 1PSL 1ZLL 2HYN
Enriched GO Terms of Interacting Partners?		Regulation Of Cardiac Muscle Cell Membrane Potential Cellular Component Assembly Response To Organic Substance Ribonucleoprotein Complex Assembly Spliceosomal SnRNP Assembly MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Death-inducing Signaling Complex Assembly Fetal Process Involved In Parturition Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Negative Regulation Of Calcium-transporting ATPase Activity Spliceosomal Complex Assembly Anatomical Structure Development Regulation Of Membrane Potential Cellular Macromolecular Complex Assembly Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Cellular Component Movement Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Rhombomere 3 Morphogenesis Rhombomere 2 Development Skeletal Muscle Cell Proliferation Negative Regulation Of Calcium Ion Binding Regulation Of The Force Of Heart Contraction By Cardiac Conduction Ribonucleoprotein Complex Biogenesis Response To Metal Ion Cell Proliferation Regulation Of Rho Protein Signal Transduction RNA Splicing Response To Osmotic Stress Apoptotic Signaling Pathway Regulation Of Metabolic Process Brain Segmentation Engulfment Of Apoptotic Cell Regulation Of Myosin-light-chain-phosphatase Activity Regulation Of Calcium-transporting ATPase Activity Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Gene Expression Vascular Endothelial Growth Factor Receptor Signaling Pathway Developmental Process Axon Guidance Extrinsic Apoptotic Signaling Pathway Mast Cell Chemotaxis Rhombomere 3 Development Positive Regulation Of Sodium Ion Export From Cell G-protein Coupled Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Cellular Metabolic Process	Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Regulation Of Heart Contraction Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Striated Muscle Contraction Sarcoplasmic Reticulum Calcium Ion Transport Chemical Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Metal Ion Homeostasis Regulation Of Muscle Contraction Relaxation Of Muscle Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cellular Chemical Homeostasis Ion Homeostasis Regulation Of Calcium Ion Transport Regulation Of Body Fluid Levels Regulation Of The Force Of Heart Contraction Calcium Ion Import Endoplasmic Reticulum Calcium Ion Homeostasis Homeostatic Process Cellular Homeostasis Epidermis Development Multicellular Organismal Water Homeostasis Calcium Ion Transport Water Homeostasis Nuclear Envelope Organization Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Positive Regulation Of Dense Core Granule Biogenesis Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Intracellular Signal Transduction Programmed Cell Death Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Cell Death Death Calcium-mediated Signaling Hair Follicle Development Hair Cycle Process Epithelium Development
Tagcloud ?		acquire arenas bioanalysis budgets capturing career celltech ei employing exactive graduating introducing joined lloyd momentum oceanography orbitrap pharma projects qc qual quan spent swansea tasked thermospray ucb whilst wyeth	augment axillary ccr7 cd45 clue conditioned cues deadly drained emerge fivefold infiltrated infiltrating intriguingly leukocyte leukocytes lymph mcf microenvironment nln nlns nodes plns secreted secretions skbr3 subsets tals tributaries
Tagcloud (Difference) ?		acquire arenas bioanalysis budgets capturing career celltech ei employing exactive graduating introducing joined lloyd momentum oceanography orbitrap pharma projects qc qual quan spent swansea tasked thermospray ucb whilst wyeth	augment axillary ccr7 cd45 clue conditioned cues deadly drained emerge fivefold infiltrated infiltrating intriguingly leukocyte leukocytes lymph mcf microenvironment nln nlns nodes plns secreted secretions skbr3 subsets tals tributaries
Tagcloud (Intersection) ?