MPP1 and KLHL12

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MPP1	KLHL12
Gene Name		membrane protein, palmitoylated 1, 55kDa	kelch-like family member 12
Image
Gene Ontology Annotations	Cellular Component	Intracellular Integral Component Of Plasma Membrane Membrane Cortical Cytoskeleton Stereocilium	Golgi Membrane Cytosol ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Guanylate Kinase Activity Protein Binding	Protein Binding
	Biological Process	Signal Transduction Nucleotide Phosphorylation Regulation Of Neutrophil Chemotaxis	Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Hematology traits ( 23263863) Mean corpuscular volume ( 23263863) Red blood cell traits ( 23446634)
Protein-Protein Interactions		19 interactors: AMOTL2 ATP5C1 DNPEP ERBB2IP GADD45A GSK3B GYPC HNRNPD KLHL12 NR1H2 OPTN RPS6KA1 RPS6KA6 SGSM2 SMN1 STK3 STUB1 TK1 ZAK	39 interactors: ARAF ATXN1 BAG6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CUL3 DGCR6 DRD4 DVL3 FGD2 FLNA GLYCTK INMT KLHL2 KLHL3 LNX1 MED28 MPP1 MRPL10 NDC80 PDGFRB PEF1 PRR13 RIT1 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TTBK2 UBE2I VEGFB VTA1 WDYHV1 ZBP1
Entrez ID		4354	59349
HPRD ID		02370	13925
Ensembl ID		ENSG00000130830	ENSG00000117153
Uniprot IDs		B4E325 Q00013	Q53G59
PDB IDs		2EJY 2EV8 3NEY	2VPJ
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Catalytic Activity Cell Death Death Regulation Of Protein Metabolic Process Positive Regulation Of JNK Cascade Signaling Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Cell Communication Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Regulation Of Protein Binding Negative Regulation Of Canonical Wnt Signaling Pathway Hippo Signaling Phosphorylation Intracellular Signal Transduction Regulation Of JNK Cascade Positive Regulation Of Cellular Metabolic Process Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Stimulus Intracellular Transport Positive Regulation Of Transferase Activity Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Fetal Process Involved In Parturition Negative Regulation Of Protein Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Binding Golgi Vesicle Transport Positive Regulation Of Cell Death Positive Regulation Of Protein Serine/threonine Kinase Activity Wnt Signaling Pathway	Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Component Assembly Positive Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Coronary Vasculature Development Actin Cytoskeleton Organization Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Chromosome Segregation Actin Filament-based Process Positive Regulation Of Catalytic Activity Anatomical Structure Development Cellular Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Modification-dependent Protein Catabolic Process Cell Projection Assembly Regulation Of MAP Kinase Activity Positive Regulation Of Cell Division Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Chemotaxis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division
Tagcloud ?		boundaries cdna conservation conserved construction discs drosophila encodes establish exon exons fugu gives heavily homology identity intron knockout lethal likewise location notion p55 palmitoylated puffer rubripes studying suppressor ubiquitously
Tagcloud (Difference) ?		boundaries cdna conservation conserved construction discs drosophila encodes establish exon exons fugu gives heavily homology identity intron knockout lethal likewise location notion p55 palmitoylated puffer rubripes studying suppressor ubiquitously
Tagcloud (Intersection) ?