MMP1 and SERPINA3

Number of citations of the paper that reports this interaction (PMID 1311327)
23

Data Source:
HPRD (in vivo, in vitro)

		MMP1	SERPINA3
Gene Name		matrix metallopeptidase 1 (interstitial collagenase)	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix	Extracellular Region Extracellular Space Intracellular Nucleus Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Proteolysis Blood Coagulation Viral Process Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein Oligomerization Cellular Protein Metabolic Process Leukocyte Migration	Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Basigin interactions Cell surface interactions at the vascular wall
Drugs		Marimastat N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE N-[3-(N\'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE
Diseases
GWAS			Body mass index ( 23669352)
Protein-Protein Interactions		17 interactors: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11	25 interactors: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 ZNRD1
Entrez ID		4312	12
HPRD ID		00384	00120
Ensembl ID		ENSG00000196611	ENSG00000196136
Uniprot IDs		B4DN15 P03956 Q53G95	G3V5I3 P01011
PDB IDs		1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C	1AS4 1QMN 2ACH 3CAA 3DLW 4CAA
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Leukocyte Migration Cell Migration Locomotion Cell Motility Monocyte Chemotaxis Organ Morphogenesis Movement Of Cell Or Subcellular Component Leukocyte Chemotaxis Chemotaxis Response To Stress Cell Chemotaxis Regulation Of Protein Metabolic Process Response To Wounding Organ Development Glycosaminoglycan Catabolic Process Blood Coagulation Inflammatory Response Hemostasis Granulocyte Chemotaxis Eosinophil Chemotaxis Response To Organic Substance Eosinophil Migration Connective Tissue Development Homeostatic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Positive Regulation Of Leukocyte Migration Negative Regulation Of Peptidase Activity Regulation Of Body Fluid Levels Developmental Process Ossification Regulation Of Cell Migration Wound Healing Proteoglycan Metabolic Process Calcium Ion Homeostasis Regulation Of Cell Motility Positive Regulation Of Chemotaxis Response To Stimulus Regulation Of Leukocyte Migration Regulation Of Locomotion Negative Regulation Of Proteolysis Regulation Of Cellular Component Movement Positive Regulation Of Behavior Regulation Of Catalytic Activity Tissue Development Negative Regulation Of Protein Processing Anatomical Structure Morphogenesis	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Proteolysis Protein Metabolic Process Killing By Host Of Symbiont Cells Defense Response Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Inflammatory Response Metabolic Process Regulation Of Protein Metabolic Process Neutrophil Mediated Immunity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Stress Killing Of Cells Of Other Organism Wound Healing Negative Regulation Of Growth Of Symbiont In Host Regulation Of Growth Defense Response To Fungus Central Nervous System Development Interaction With Symbiont Leukocyte Mediated Cytotoxicity Peptide Hormone Processing Response To Wounding Negative Regulation Of Cytokine Biosynthetic Process Response To Fungus Blood Coagulation Inflammatory Response Hemostasis Defense Response To Bacterium Negative Regulation Of Interleukin-12 Biosynthetic Process Interleukin-1 Beta Biosynthetic Process Neuromuscular Junction Development Response To Bacterium Regulation Of Angiogenesis Protein Processing Negative Regulation Of Growth Collagen Catabolic Process Facial Nucleus Development Leading Strand Elongation Factor XII Activation Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Platelet Degranulation Regulation Of Body Fluid Levels Regulation Of Translation Acute Inflammatory Response
Tagcloud ?		artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 map3k10 merits nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2	add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported
Tagcloud (Difference) ?		artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 map3k10 merits nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2	add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported
Tagcloud (Intersection) ?