MMP1 and ITGA2

Number of citations of the paper that reports this interaction (PMID 11359786)
33

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		MMP1	ITGA2
Gene Name		matrix metallopeptidase 1 (interstitial collagenase)	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix	Nucleus Plasma Membrane Focal Adhesion Integrin Complex Cell Outer Membrane External Side Of Plasma Membrane Cell Surface Integrin Alpha2-beta1 Complex Axon Terminus Basal Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding	Virus Receptor Activity Integrin Binding Protein Binding Collagen Binding Collagen Receptor Activity Laminin Binding Metal Ion Binding Protein Heterodimerization Activity Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process	Proteolysis Blood Coagulation Viral Process Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein Oligomerization Cellular Protein Metabolic Process Leukocyte Migration	Response To Hypoxia Positive Regulation Of Leukocyte Migration Substrate-dependent Cell Migration Hypotonic Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Cell Proliferation Response To Virus Organ Morphogenesis Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Response To Organic Cyclic Compound Response To Amine Response To Muscle Activity Positive Regulation Of Smooth Muscle Cell Migration Viral Process Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of Cell Projection Organization Cell-substrate Adhesion Cellular Response To Hormone Stimulus Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Binding Response To L-ascorbic Acid Cell Adhesion Mediated By Integrin Collagen-activated Signaling Pathway Response To Drug Positive Regulation Of DNA Binding Skin Morphogenesis Establishment Of Protein Localization Positive Regulation Of Translation Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Contraction Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Positive Chemotaxis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Phagocytosis, Engulfment Hepatocyte Differentiation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Basigin interactions Cell surface interactions at the vascular wall	Syndecan interactions Platelet Adhesion to exposed collagen Axon guidance CHL1 interactions Laminin interactions ECM proteoglycans L1CAM interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions
Drugs		Marimastat N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE N-[3-(N\'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11	12 interactors: ACTA1 AUP1 CD9 COL1A1 COL1A2 COL8A1 HSPG2 ITGB1 LAMA1 MMP1 RABIF SHARPIN
Entrez ID		4312	3673
HPRD ID		00384	01893
Ensembl ID		ENSG00000196611	ENSG00000164171
Uniprot IDs		B4DN15 P03956 Q53G95	P17301
PDB IDs		1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C	1AOX 1DZI 1PQB 1V7P
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Leukocyte Migration Cell Migration Locomotion Cell Motility Monocyte Chemotaxis Organ Morphogenesis Movement Of Cell Or Subcellular Component Leukocyte Chemotaxis Chemotaxis Response To Stress Cell Chemotaxis Regulation Of Protein Metabolic Process Response To Wounding Organ Development Glycosaminoglycan Catabolic Process Blood Coagulation Inflammatory Response Hemostasis Granulocyte Chemotaxis Eosinophil Chemotaxis Response To Organic Substance Eosinophil Migration Connective Tissue Development Homeostatic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Positive Regulation Of Leukocyte Migration Negative Regulation Of Peptidase Activity Regulation Of Body Fluid Levels Developmental Process Ossification Regulation Of Cell Migration Wound Healing Proteoglycan Metabolic Process Calcium Ion Homeostasis Regulation Of Cell Motility Positive Regulation Of Chemotaxis Response To Stimulus Regulation Of Leukocyte Migration Regulation Of Locomotion Negative Regulation Of Proteolysis Regulation Of Cellular Component Movement Positive Regulation Of Behavior Regulation Of Catalytic Activity Tissue Development Negative Regulation Of Protein Processing Anatomical Structure Morphogenesis	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Blood Vessel Development Multicellular Organismal Macromolecule Metabolic Process Vasculature Development Multicellular Organismal Metabolic Process Organ Development Blood Coagulation Hemostasis Cardiovascular System Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Leukocyte Migration Tissue Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Body Fluid Levels Wound Healing System Development Response To Wounding Protein Heterotrimerization Head Development Multicellular Organismal Development Cell Differentiation Anatomical Structure Development Blood Vessel Morphogenesis Organ Morphogenesis Developmental Process Response To Abiotic Stimulus Response To Transforming Growth Factor Beta Regulation Of Cell-substrate Adhesion Cellular Component Assembly Platelet Activation Response To Mechanical Stimulus Protein Trimerization Cellular Response To Nutrient Regulation Of Cell Adhesion Cartilage Development Involved In Endochondral Bone Morphogenesis Skin Development Locomotion Endochondral Ossification Cell Activation Skin Morphogenesis Brain Development Striated Muscle Tissue Development Cellular Response To Amino Acid Stimulus Collagen Fibril Organization Angiogenesis
Tagcloud ?		artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 map3k10 merits nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Difference) ?		artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 irf2 map3k10 merits nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Intersection) ?