ACHE and COL1A1

Number of citations of the paper that reports this interaction (PMID 12524166)
4

Data Source:
BioGRID (pull down)

		ACHE	COL1A1
Gene Name		acetylcholinesterase (Yt blood group)	collagen, type I, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Basal Lamina Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Cell Surface Membrane Cell Junction Anchored Component Of Membrane Neuromuscular Junction Synapse Perinuclear Region Of Cytoplasm	Extracellular Region Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Secretory Granule Extracellular Matrix
	Molecular Function	Beta-amyloid Binding Acetylcholinesterase Activity Cholinesterase Activity Protein Binding Collagen Binding Hydrolase Activity Serine Hydrolase Activity Acetylcholine Binding Protein Homodimerization Activity Laminin Binding Protein Self-association	Extracellular Matrix Structural Constituent Protein Binding Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Receptor Recycling Osteoblast Development DNA Replication Acetylcholine Catabolic Process Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cell Adhesion Synaptic Transmission Nervous System Development Synapse Assembly Muscle Organ Development Cell Proliferation Response To Wounding Receptor Internalization Negative Regulation Of Synaptic Transmission, Cholinergic Neurotransmitter Biosynthetic Process Amyloid Precursor Protein Metabolic Process Small Molecule Metabolic Process Neurotransmitter Receptor Biosynthetic Process Glycerophospholipid Biosynthetic Process Positive Regulation Of Protein Secretion Protein Tetramerization Retina Development In Camera-type Eye	Skeletal System Development Blood Vessel Development Osteoblast Differentiation Intramembranous Ossification Endochondral Ossification Receptor-mediated Endocytosis Blood Coagulation Visual Perception Sensory Perception Of Sound Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Protein Transport Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Corticosteroid Response To Estradiol Collagen Biosynthetic Process Protein Localization To Nucleus Tooth Mineralization Response To Drug Response To Hydrogen Peroxide Response To Peptide Hormone Skin Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Tooth Eruption Positive Regulation Of Transcription, DNA-templated Embryonic Skeletal System Development Leukocyte Migration Response To CAMP Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Cartilage Development Involved In Endochondral Bone Morphogenesis Protein Heterotrimerization Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Vitamin E Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Fluoride
Pathways		Synthesis of PC Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Metabolism of lipids and lipoproteins Neurotransmitter Clearance In The Synaptic Cleft Phospholipid metabolism Glycerophospholipid biosynthesis Transmission across Chemical Synapses	Platelet Adhesion to exposed collagen Collagen formation Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Syndecan interactions Crosslinking of collagen fibrils ECM proteoglycans GPVI-mediated activation cascade Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Platelet activation, signaling and aggregation Scavenging by Class A Receptors
Drugs		Choline Tacrine Gallamine Triethiodide Pyridostigmine Galantamine Isoflurophate Pralidoxime Minaprine Donepezil Demecarium Physostigmine Rivastigmine Edrophonium Ambenonium Tubocurarine Decamethonium Ephedrine Neostigmine Monoisopropylphosphorylserine Huperaine A Propidium 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium 3,6,9,12,15-Pentaoxaheptadecane 1-Deoxy-1-Thio-Heptaethylene Glycol (4ar,6s,8ar)-11-[8-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Octyl]-6-Hydroxy-3-Methoxy-5,6,9,10-Tetrahydro-4ah-[1]Benzofuro[3a,3,2-Ef][2]Benzazepin-11-Ium Methylphosphonic Acid Ester Group Methylphosphinic Acid 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium Acetylcholine beta-L-fucose M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose 2-(N-Morpholino)-Ethanesulfonic Acid MF268 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine 3-[(1s)-1-(Dimethylamino)Ethyl]Phenol (R)-tacrine(10)-hupyridone (S)-tacrine(10)-hupyridone TACRINE(8)-4-AMINOQUINOLINE (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM 1-(2-nitrophenyl)-2,2,2-trifluoroethyl]-arsenocholine 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL (1R)-1,2,2-TRIMETHYLPROPYL (S)-METHYLPHOSPHINATE 1S,3AS,8AS-TRIMETHYL-1-OXIDO-1,2,3,3A,8,8A-HEXAHYDROPYRROLO[2,3-B]INDOL-5-YL 2-ETHYLPHENYLCARBAMATE 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM	Collagenase
Diseases
GWAS		Heart rate ( 23583979) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Type 2 diabetes ( 21490949)	Breast cancer ( 17903305) Response to taxane treatment (docetaxel) ( 23006423)
Protein-Protein Interactions		9 interactors: APP COL1A1 COL4A1 COLQ EIF2D HAND1 LAMA1 LAMB1 PRIMA1	37 interactors: ACHE ATP13A2 BARD1 BGN BMP1 BRCA1 CAPN1 CD36 CD44 CD93 COL7A1 DCN DDR2 FGF7 FN1 HTRA1 IGFBP3 ITGA2 ITGA5 MAG MATN2 MMP2 MMP9 NID1 NID2 P4HB PAK1 PDGFA PDGFB PKD1 PRELP SPARC TGFBI THBS1 TMPRSS6 TXN VWF
Entrez ID		43	1277
HPRD ID		00010	00362
Ensembl ID		ENSG00000087085	ENSG00000108821
Uniprot IDs		P22303	P02452
PDB IDs		1B41 1F8U 1PUV 1PUW 1VZJ 2CLJ 2X8B 3LII 4BDT 4EY4 4EY5 4EY6 4EY7 4EY8	1Q7D 2LLP 3EJH 3GXE
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Retinal Blood Vessel Morphogenesis Extracellular Matrix Disassembly Axon Guidance Retina Vasculature Morphogenesis In Camera-type Eye Neurotransmitter Catabolic Process Odontogenesis Blood Vessel Development Axonogenesis Vasculature Development Retina Vasculature Development In Camera-type Eye Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Chemotaxis Neurotransmitter Metabolic Process Neuron Projection Morphogenesis Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Head Development Neuron Projection Development Cell Projection Morphogenesis Neuromuscular Junction Development Cell Part Morphogenesis Cardiovascular System Development Tissue Development Cellular Response To Amino Acid Stimulus Organ Development Response To External Stimulus Collagen Catabolic Process Neuron Development Epithelial Tube Morphogenesis Organ Morphogenesis Embryonic Heart Tube Formation Neuronal-glial Interaction Involved In Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Cellular Response To Fluoride Collagen Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Cell Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Blood Vessel Morphogenesis Tube Morphogenesis Cell Differentiation Multicellular Organismal Metabolic Process Neuron Differentiation Cell Projection Organization Morphogenesis Of An Epithelium	Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Extracellular Matrix Disassembly Wound Healing Multicellular Organismal Development Cell Adhesion Anatomical Structure Development Tissue Development Platelet Degranulation Developmental Process System Development Blood Coagulation Hemostasis Anatomical Structure Morphogenesis Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Protein Metabolic Process Regulation Of Locomotion Regulation Of Cellular Amino Acid Metabolic Process Response To Stress Regulation Of Cellular Component Movement Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Body Fluid Levels Regulation Of Cell Migration Cell-substrate Adhesion Regulation Of Epithelial Cell Migration Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Phosphorylation Endodermal Cell Differentiation Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Skeletal System Development Regulation Of Cellular Protein Metabolic Process Organ Development Blood Vessel Morphogenesis Regulation Of Phosphorus Metabolic Process Platelet Activation Organ Morphogenesis Locomotion Endoderm Formation Angiogenesis Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Exocytosis
Tagcloud ?		acetylcholinesterase amphetamine atropine bring ceb diazepam drl irreversible ld50 mecamylamine methylatropine modafinil muscarinic opc organophosphorus oximes physostigmine pralidoxime psychotropic pyridostigmine pyrimidoxime reinforcement responding sarin schedule scopolamine soman subtoxic wakening	archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools
Tagcloud (Difference) ?		acetylcholinesterase amphetamine atropine bring ceb diazepam drl irreversible ld50 mecamylamine methylatropine modafinil muscarinic opc organophosphorus oximes physostigmine pralidoxime psychotropic pyridostigmine pyrimidoxime reinforcement responding sarin schedule scopolamine soman subtoxic wakening	archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools
Tagcloud (Intersection) ?