ACHE and LAMA1

Number of citations of the paper that reports this interaction (PMID 12524166)
4

Data Source:
HPRD (in vitro)

		ACHE	LAMA1
Gene Name		acetylcholinesterase (Yt blood group)	laminin, alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basal Lamina Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Cell Surface Membrane Cell Junction Anchored Component Of Membrane Neuromuscular Junction Synapse Perinuclear Region Of Cytoplasm	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Laminin-1 Complex Laminin-3 Complex Extracellular Space Cell-cell Junction Extracellular Matrix
	Molecular Function	Beta-amyloid Binding Acetylcholinesterase Activity Cholinesterase Activity Protein Binding Collagen Binding Hydrolase Activity Serine Hydrolase Activity Acetylcholine Binding Protein Homodimerization Activity Laminin Binding Protein Self-association	Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Glycosphingolipid Binding
	Biological Process	Acetylcholine Catabolic Process In Synaptic Cleft Regulation Of Receptor Recycling Osteoblast Development DNA Replication Acetylcholine Catabolic Process Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cell Adhesion Synaptic Transmission Nervous System Development Synapse Assembly Muscle Organ Development Cell Proliferation Response To Wounding Receptor Internalization Negative Regulation Of Synaptic Transmission, Cholinergic Neurotransmitter Biosynthetic Process Amyloid Precursor Protein Metabolic Process Small Molecule Metabolic Process Neurotransmitter Receptor Biosynthetic Process Glycerophospholipid Biosynthetic Process Positive Regulation Of Protein Secretion Protein Tetramerization Retina Development In Camera-type Eye	Morphogenesis Of An Epithelial Sheet Cell Adhesion Cell Surface Receptor Signaling Pathway Axon Guidance Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Embryonic Development Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Retinal Blood Vessel Morphogenesis
Pathways		Synthesis of PC Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Metabolism of lipids and lipoproteins Neurotransmitter Clearance In The Synaptic Cleft Phospholipid metabolism Glycerophospholipid biosynthesis Transmission across Chemical Synapses	Axon guidance Laminin interactions ECM proteoglycans L1CAM interactions Non-integrin membrane-ECM interactions
Drugs		Choline Tacrine Gallamine Triethiodide Pyridostigmine Galantamine Isoflurophate Pralidoxime Minaprine Donepezil Demecarium Physostigmine Rivastigmine Edrophonium Ambenonium Tubocurarine Decamethonium Ephedrine Neostigmine Monoisopropylphosphorylserine Huperaine A Propidium 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium 3,6,9,12,15-Pentaoxaheptadecane 1-Deoxy-1-Thio-Heptaethylene Glycol (4ar,6s,8ar)-11-[8-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Octyl]-6-Hydroxy-3-Methoxy-5,6,9,10-Tetrahydro-4ah-[1]Benzofuro[3a,3,2-Ef][2]Benzazepin-11-Ium Methylphosphonic Acid Ester Group Methylphosphinic Acid 3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium Acetylcholine beta-L-fucose M-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene 2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose 2-(N-Morpholino)-Ethanesulfonic Acid MF268 3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine 3-[(1s)-1-(Dimethylamino)Ethyl]Phenol (R)-tacrine(10)-hupyridone (S)-tacrine(10)-hupyridone TACRINE(8)-4-AMINOQUINOLINE (9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM 1-(2-nitrophenyl)-2,2,2-trifluoroethyl]-arsenocholine 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL (1R)-1,2,2-TRIMETHYLPROPYL (S)-METHYLPHOSPHINATE 1S,3AS,8AS-TRIMETHYL-1-OXIDO-1,2,3,3A,8,8A-HEXAHYDROPYRROLO[2,3-B]INDOL-5-YL 2-ETHYLPHENYLCARBAMATE 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE 2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM
Diseases
GWAS		Heart rate ( 23583979) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Type 2 diabetes ( 21490949)	Response to citalopram treatment ( 22760553) Type 2 diabetes ( 22693455)
Protein-Protein Interactions		9 interactors: APP COL1A1 COL4A1 COLQ EIF2D HAND1 LAMA1 LAMB1 PRIMA1	19 interactors: ACHE APCS APP C3 COL7A1 DAG1 FBLN2 HSPG2 ITGA1 ITGA2 ITGB1 MEP1A NID1 NT5E PLAT PLG SAA1 SAA2 TMPRSS6
Entrez ID		43	284217
HPRD ID		00010	01033
Ensembl ID		ENSG00000087085	ENSG00000101680
Uniprot IDs		P22303	P25391
PDB IDs		1B41 1F8U 1PUV 1PUW 1VZJ 2CLJ 2X8B 3LII 4BDT 4EY4 4EY5 4EY6 4EY7 4EY8
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Retinal Blood Vessel Morphogenesis Extracellular Matrix Disassembly Axon Guidance Retina Vasculature Morphogenesis In Camera-type Eye Neurotransmitter Catabolic Process Odontogenesis Blood Vessel Development Axonogenesis Vasculature Development Retina Vasculature Development In Camera-type Eye Axon Development Cell Morphogenesis Involved In Neuron Differentiation Locomotion Chemotaxis Neurotransmitter Metabolic Process Neuron Projection Morphogenesis Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Head Development Neuron Projection Development Cell Projection Morphogenesis Neuromuscular Junction Development Cell Part Morphogenesis Cardiovascular System Development Tissue Development Cellular Response To Amino Acid Stimulus Organ Development Response To External Stimulus Collagen Catabolic Process Neuron Development Epithelial Tube Morphogenesis Organ Morphogenesis Embryonic Heart Tube Formation Neuronal-glial Interaction Involved In Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Cellular Response To Fluoride Collagen Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Cell Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Blood Vessel Morphogenesis Tube Morphogenesis Cell Differentiation Multicellular Organismal Metabolic Process Neuron Differentiation Cell Projection Organization Morphogenesis Of An Epithelium	Extracellular Matrix Organization Extracellular Structure Organization Blood Coagulation Hemostasis Response To Wounding Cell-matrix Adhesion Regulation Of Body Fluid Levels Negative Regulation Of Wound Healing Wound Healing Cell-substrate Adhesion Extracellular Matrix Disassembly Cell Adhesion Fibrinolysis Regulation Of Inflammatory Response Locomotion Regulation Of Wound Healing Acute-phase Response Viral Entry Into Host Cell Chemotaxis Entry Into Host Cell Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Movement Of Cell Or Subcellular Component Axon Guidance Negative Regulation Of Blood Coagulation Response To Stress Regulation Of Cell-substrate Adhesion Negative Regulation Of Coagulation Acute Inflammatory Response Leukocyte Migration Cell Migration Axonogenesis Cell Motility Cell Adhesion Mediated By Integrin Basement Membrane Organization Axon Development Positive Regulation Of Endocytosis Regulation Of Blood Coagulation Cell Morphogenesis Involved In Neuron Differentiation Interaction With Host Negative Regulation Of Inflammatory Response Positive Regulation Of Cell-substrate Adhesion Integrin-mediated Signaling Pathway Neuron Projection Morphogenesis Regulation Of Protein Metabolic Process Formation Of Primary Germ Layer Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport
Tagcloud ?		acetylcholinesterase amphetamine atropine bring ceb diazepam drl irreversible ld50 mecamylamine methylatropine modafinil muscarinic opc organophosphorus oximes physostigmine pralidoxime psychotropic pyridostigmine pyrimidoxime reinforcement responding sarin schedule scopolamine soman subtoxic wakening	annexin2 col1a1 committed desensitized ecm fbln1 fbn2 fibrillin fibullin fn1 has1 hsc hyaluronan ifi ifi44l ifit1 ifnbeta isgf3 laminin mineralization modifies niche opn osteoblast osteoblasts osteoimmunology osteopontin pinpoints timing
Tagcloud (Difference) ?		acetylcholinesterase amphetamine atropine bring ceb diazepam drl irreversible ld50 mecamylamine methylatropine modafinil muscarinic opc organophosphorus oximes physostigmine pralidoxime psychotropic pyridostigmine pyrimidoxime reinforcement responding sarin schedule scopolamine soman subtoxic wakening	annexin2 col1a1 committed desensitized ecm fbln1 fbn2 fibrillin fibullin fn1 has1 hsc hyaluronan ifi ifi44l ifit1 ifnbeta isgf3 laminin mineralization modifies niche opn osteoblast osteoblasts osteoimmunology osteopontin pinpoints timing
Tagcloud (Intersection) ?