COL1A1 and FGF7

Number of citations of the paper that reports this interaction (PMID 11973338)
8

Data Source:
HPRD (in vitro)

		COL1A1	FGF7
Gene Name		collagen, type I, alpha 1	fibroblast growth factor 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Secretory Granule Extracellular Matrix	Extracellular Region Golgi Apparatus
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity
	Biological Process	Skeletal System Development Blood Vessel Development Osteoblast Differentiation Intramembranous Ossification Endochondral Ossification Receptor-mediated Endocytosis Blood Coagulation Visual Perception Sensory Perception Of Sound Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Protein Transport Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Corticosteroid Response To Estradiol Collagen Biosynthetic Process Protein Localization To Nucleus Tooth Mineralization Response To Drug Response To Hydrogen Peroxide Response To Peptide Hormone Skin Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Tooth Eruption Positive Regulation Of Transcription, DNA-templated Embryonic Skeletal System Development Leukocyte Migration Response To CAMP Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Cartilage Development Involved In Endochondral Bone Morphogenesis Protein Heterotrimerization Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Vitamin E Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Fluoride	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Epidermis Development Response To Wounding Mesenchymal Cell Proliferation Positive Regulation Of Keratinocyte Proliferation Hair Follicle Morphogenesis Actin Cytoskeleton Reorganization Protein Localization To Cell Surface Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Cell Division Branching Involved In Salivary Gland Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Secretion By Lung Epithelial Cell Involved In Lung Growth
Pathways		Platelet Adhesion to exposed collagen Collagen formation Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Syndecan interactions Crosslinking of collagen fibrils ECM proteoglycans GPVI-mediated activation cascade Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Platelet activation, signaling and aggregation Scavenging by Class A Receptors	Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Downstream signaling of activated FGFR FGFR ligand binding and activation FGFR2b ligand binding and activation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling FGFR2 ligand binding and activation FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade
Drugs		Collagenase
Diseases
GWAS		Breast cancer ( 17903305) Response to taxane treatment (docetaxel) ( 23006423)	Thyroid hormone levels ( 23408906) Thyroid volume ( 21565293)
Protein-Protein Interactions		37 interactors: ACHE ATP13A2 BARD1 BGN BMP1 BRCA1 CAPN1 CD36 CD44 CD93 COL7A1 DCN DDR2 FGF7 FN1 HTRA1 IGFBP3 ITGA2 ITGA5 MAG MATN2 MMP2 MMP9 NID1 NID2 P4HB PAK1 PDGFA PDGFB PKD1 PRELP SPARC TGFBI THBS1 TMPRSS6 TXN VWF	13 interactors: COL1A1 COL2A1 COL3A1 COL6A1 DESI1 DUSP3 FGFR1 FGFR2 FGFR3 FGFR4 HSPG2 NRP1 UBQLN1
Entrez ID		1277	2252
HPRD ID		00362	01022
Ensembl ID		ENSG00000108821
Uniprot IDs		P02452	P21781 Q6FGV5
PDB IDs		1Q7D 2LLP 3EJH 3GXE
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Extracellular Matrix Disassembly Wound Healing Multicellular Organismal Development Cell Adhesion Anatomical Structure Development Tissue Development Platelet Degranulation Developmental Process System Development Blood Coagulation Hemostasis Anatomical Structure Morphogenesis Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Protein Metabolic Process Regulation Of Locomotion Regulation Of Cellular Amino Acid Metabolic Process Response To Stress Regulation Of Cellular Component Movement Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Body Fluid Levels Regulation Of Cell Migration Cell-substrate Adhesion Regulation Of Epithelial Cell Migration Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Phosphorylation Endodermal Cell Differentiation Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Skeletal System Development Regulation Of Cellular Protein Metabolic Process Organ Development Blood Vessel Morphogenesis Regulation Of Phosphorus Metabolic Process Platelet Activation Organ Morphogenesis Locomotion Endoderm Formation Angiogenesis Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Exocytosis	Cellular Response To Growth Factor Stimulus Response To Growth Factor Tissue Development Extracellular Matrix Disassembly Cellular Response To Organonitrogen Compound Cellular Response To Organic Substance Skeletal System Morphogenesis Axonogenesis Bone Morphogenesis Ossification Skeletal System Development Endochondral Ossification Axon Development Cell Morphogenesis Involved In Neuron Differentiation Organ Morphogenesis Neuron Projection Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Embryo Development Cell Morphogenesis Involved In Differentiation Collagen Catabolic Process Inner Ear Development Response To Organic Substance Regulation Of ERK1 And ERK2 Cascade Cartilage Development Neurotrophin TRK Receptor Signaling Pathway Head Development Neuron Projection Development Collagen Metabolic Process Otic Vesicle Development Neurotrophin Signaling Pathway Response To Organonitrogen Compound Cell Projection Morphogenesis Bone Development Endochondral Bone Morphogenesis Regulation Of Signal Transduction Multicellular Organismal Macromolecule Metabolic Process Chondrocyte Differentiation Ear Development Cell Part Morphogenesis Cardiovascular System Development Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Metabolic Process Connective Tissue Development Blood Vessel Development Vasculature Development Peptidyl-tyrosine Phosphorylation Inner Ear Morphogenesis Neuron Development Central Nervous System Development
Tagcloud ?		archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools	abrogated abundance ck1 correlates csnk1e disrupting erk fgf1 fgfr fibroblast grb2 message modulated motifs negatively neurite outgrowth pc12 ras sevenless son sos sprouty2 spry2 structurally therapeutically transcript transduces
Tagcloud (Difference) ?		archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools	abrogated abundance ck1 correlates csnk1e disrupting erk fgf1 fgfr fibroblast grb2 message modulated motifs negatively neurite outgrowth pc12 ras sevenless son sos sprouty2 spry2 structurally therapeutically transcript transduces
Tagcloud (Intersection) ?