MAP1A and HTR2A

Number of citations of the paper that reports this interaction (PMID 16537434)
10

Data Source:
HPRD (two hybrid)

		MAP1A	HTR2A
Gene Name		microtubule-associated protein 1A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Microtubule Microtubule Associated Complex	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola Cytoplasmic Membrane-bounded Vesicle Axon Neuronal Cell Body Dendritic Shaft Cell Body Fiber
	Molecular Function	Structural Molecule Activity Protein Binding Microtubule Binding	G-protein Alpha-subunit Binding Serotonin Receptor Activity Drug Binding Protein Complex Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding
	Biological Process	Microtubule Cytoskeleton Organization Sensory Perception Of Sound	Temperature Homeostasis Cellular Calcium Ion Homeostasis Activation Of Phospholipase C Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Aging Memory Cell Death Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Dopamine Secretion Phosphatidylinositol 3-kinase Signaling Artery Smooth Muscle Contraction Urinary Bladder Smooth Muscle Contraction Sleep Response To Drug Negative Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Protein Localization To Cytoskeleton Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Vasoconstriction Regulation Of Hormone Secretion Behavioral Response To Cocaine Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Behavior Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs		Estramustine	Ziprasidone Methysergide Cabergoline Ropinirole Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Remoxipride Pramipexole Promazine Cyproheptadine Imipramine Chlorpromazine Haloperidol Nortriptyline Lisuride Cisapride Trazodone Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Epinastine Propiomazine Minaprine Donepezil Flupenthixol Cyclobenzaprine Mesoridazine Promethazine Tegaserod Doxepin Nefazodone Desipramine Pergolide Bromocriptine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Dihydroergotoxine Yohimbine Methotrimeprazine MMDA 3,4-Methylenedioxymethamphetamine Dimethyltryptamine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Iloperidone Sertindole Mianserin Asenapine Amisulpride Cinitapride Lurasidone
Diseases
GWAS			Cardiac hypertrophy ( 21348951) Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		22 interactors: ACTA1 ACTG1 AP1G1 ARHGEF11 CACNB4 DISC1 DLG1 DLG2 DLG4 GRB2 HTR2A KCNMA1 MAP1B MAP1LC3A NXF1 NXF2 RAPGEF3 RAPGEF4 SPP1 TUBA4A TUBB UPF2	16 interactors: ANKS1B DLG4 EIF3F GLUL GNA11 GNAI1 GNAQ JAK2 MAP1A MRPL28 NDUFB10 NME3 NTRK3 PON2 PPP5C RPS6KA3
Entrez ID		4130	3356
HPRD ID		02549	01638
Ensembl ID		ENSG00000166963	ENSG00000102468
Uniprot IDs		E9PGC8 P78559 Q504X9	P28223
PDB IDs
Enriched GO Terms of Interacting Partners?		Movement Of Cell Or Subcellular Component Cellular Localization Receptor Localization To Synapse Response To External Stimulus Cytoskeleton Organization Axonogenesis Axon Development Protein Localization To Synapse Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Platelet Activation Cell-cell Signaling Developmental Process Axon Guidance Neuron Projection Morphogenesis Muscle Contraction Blood Coagulation Hemostasis Cell Morphogenesis Involved In Differentiation Muscle System Process Establishment Of Localization In Cell Generation Of Neurons Neuron Projection Development Response To Stimulus Cell Projection Morphogenesis Neurogenesis Cell Part Morphogenesis Locomotion Multicellular Organismal Development Regulation Of Body Fluid Levels Cell Differentiation Synaptic Transmission Wound Healing System Development Nervous System Development Receptor Clustering Transport Neuron Development Cell Development Smooth Muscle Contraction Nucleotide Phosphorylation Establishment Or Maintenance Of Cell Polarity Cell Activation MRNA Export From Nucleus Cytoplasmic Transport Cellular Metal Ion Homeostasis Response To Wounding Cell Morphogenesis Organelle Organization Intracellular Transport	Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Melanocyte Differentiation Response To Wounding Response To Stress Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Developmental Pigmentation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Platelet Activation Dopamine Receptor Signaling Pathway Regulation Of Body Fluid Levels Synaptic Transmission Wound Healing Neuron Differentiation Nucleotide Phosphorylation Phosphorylation Regulation Of Membrane Potential Histone H3-Y41 Phosphorylation Host Programmed Cell Death Induced By Symbiont Positive Regulation Of Axon Extension Involved In Regeneration Modulation By Virus Of Host Transcription Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Developmental Pigmentation Positive Regulation Of Insulin Secretion Response To Axon Injury Phosphate-containing Compound Metabolic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Glutamine Biosynthetic Process Mineralocorticoid Receptor Signaling Pathway Action Potential Interleukin-12-mediated Signaling Pathway Positive Regulation Of Growth Hormone Receptor Signaling Pathway Activation Of JAK2 Kinase Activity Generation Of Neurons Positive Regulation Of Hormone Secretion Cell-cell Signaling Regulation Of Cell Differentiation Positive Regulation Of Synaptic Transmission Neuron Development Pigmentation Positive Regulation Of Cell Growth Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein Neurogenesis Signaling Posttranscriptional Regulation Of Gene Expression Response To Organic Substance Cell Communication
Tagcloud ?		1b adapting apparently assign chain chains coimmunoprecipitation consisting cooh dimerize entire epitope filament flexible fragments harbor heavy homologous immunofluorescence light map1b maps microtubule microtubules nocodazole oligomerize tagged taxol transiently	adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic slc6a1 slc6a3 trajectories variations
Tagcloud (Difference) ?		1b adapting apparently assign chain chains coimmunoprecipitation consisting cooh dimerize entire epitope filament flexible fragments harbor heavy homologous immunofluorescence light map1b maps microtubule microtubules nocodazole oligomerize tagged taxol transiently	adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic slc6a1 slc6a3 trajectories variations
Tagcloud (Intersection) ?