HTR2A and PPP5C

Number of citations of the paper that reports this interaction (PMID 16537434)
10

Data Source:
HPRD (two hybrid)

		HTR2A	PPP5C
Gene Name		5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	protein phosphatase 5, catalytic subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola Cytoplasmic Membrane-bounded Vesicle Axon Neuronal Cell Body Dendritic Shaft Cell Body Fiber	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle
	Molecular Function	G-protein Alpha-subunit Binding Serotonin Receptor Activity Drug Binding Protein Complex Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Signal Transducer Activity Protein Binding Lipid Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Temperature Homeostasis Cellular Calcium Ion Homeostasis Activation Of Phospholipase C Activity Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Aging Memory Cell Death Positive Regulation Of Cell Proliferation Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Dopamine Secretion Phosphatidylinositol 3-kinase Signaling Artery Smooth Muscle Contraction Urinary Bladder Smooth Muscle Contraction Sleep Response To Drug Negative Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Protein Localization To Cytoskeleton Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycolytic Process Positive Regulation Of Vasoconstriction Regulation Of Hormone Secretion Behavioral Response To Cocaine Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Behavior Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade	DNA Repair Transcription, DNA-templated Protein Dephosphorylation Mitotic Nuclear Division Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Morphine Protein Heterooligomerization
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs		Ziprasidone Methysergide Cabergoline Ropinirole Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Remoxipride Pramipexole Promazine Cyproheptadine Imipramine Chlorpromazine Haloperidol Nortriptyline Lisuride Cisapride Trazodone Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Epinastine Propiomazine Minaprine Donepezil Flupenthixol Cyclobenzaprine Mesoridazine Promethazine Tegaserod Doxepin Nefazodone Desipramine Pergolide Bromocriptine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Dihydroergotoxine Yohimbine Methotrimeprazine MMDA 3,4-Methylenedioxymethamphetamine Dimethyltryptamine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Iloperidone Sertindole Mianserin Asenapine Amisulpride Cinitapride Lurasidone
Diseases
GWAS		Cardiac hypertrophy ( 21348951) Subcutaneous adipose tissue ( 22589738)
Protein-Protein Interactions		16 interactors: ANKS1B DLG4 EIF3F GLUL GNA11 GNAI1 GNAQ JAK2 MAP1A MRPL28 NDUFB10 NME3 NTRK3 PON2 PPP5C RPS6KA3	22 interactors: APP CDC16 CDC27 CDK20 CHORDC1 CPNE1 CPNE2 CPNE4 CRY2 CSE1L DISC1 EGFR ESR2 GNA12 GNA13 HSP90AA1 HTR2A MAP3K5 MAP3K7 MAPT PPP2R1A PPP2R3A
Entrez ID		3356	5536
HPRD ID		01638	02805
Ensembl ID		ENSG00000102468	ENSG00000011485
Uniprot IDs		P28223	B7Z1I1 P53041
PDB IDs			1A17 1S95 1WAO 2BUG 3H60 3H61 3H62 3H63 3H64 3H66 3H67 3H68 3H69
Enriched GO Terms of Interacting Partners?		Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Melanocyte Differentiation Response To Wounding Response To Stress Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Developmental Pigmentation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Blood Coagulation Hemostasis Platelet Activation Dopamine Receptor Signaling Pathway Regulation Of Body Fluid Levels Synaptic Transmission Wound Healing Neuron Differentiation Nucleotide Phosphorylation Phosphorylation Regulation Of Membrane Potential Histone H3-Y41 Phosphorylation Host Programmed Cell Death Induced By Symbiont Positive Regulation Of Axon Extension Involved In Regeneration Modulation By Virus Of Host Transcription Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Developmental Pigmentation Positive Regulation Of Insulin Secretion Response To Axon Injury Phosphate-containing Compound Metabolic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Glutamine Biosynthetic Process Mineralocorticoid Receptor Signaling Pathway Action Potential Interleukin-12-mediated Signaling Pathway Positive Regulation Of Growth Hormone Receptor Signaling Pathway Activation Of JAK2 Kinase Activity Generation Of Neurons Positive Regulation Of Hormone Secretion Cell-cell Signaling Regulation Of Cell Differentiation Positive Regulation Of Synaptic Transmission Neuron Development Pigmentation Positive Regulation Of Cell Growth Tyrosine Phosphorylation Of Stat1 Protein Tyrosine Phosphorylation Of Stat5 Protein Neurogenesis Signaling Posttranscriptional Regulation Of Gene Expression Response To Organic Substance Cell Communication	Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Cell Death Death Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Regulation Of Signal Transduction Regulation Of MAP Kinase Activity Positive Regulation Of Proteolysis Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Apoptotic Process Regulation Of Signaling Programmed Cell Death Regulation Of Proteolysis Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Catalytic Activity Intracellular Receptor Signaling Pathway Activation Of MAPKK Activity Positive Regulation Of Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Signaling Negative Regulation Of Catalytic Activity Metal Ion Homeostasis Positive Regulation Of Phospholipase Activity Cellular Protein Metabolic Process Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Phospholipase Activity Chemical Homeostasis Positive Regulation Of Lipase Activity Regulation Of Phosphorylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Morphogenesis Intracellular Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway
Tagcloud ?		adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic slc6a1 slc6a3 trajectories variations	cantharidin catalytic communities date desired fluorescent greatly libraries microcystin okadaic optimization pharmaceutical phosphatase phosphatases pp1 pp1alpha pp1calpha ppp1c representative robust screen selectively share simultaneously threonine z
Tagcloud (Difference) ?		adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic slc6a1 slc6a3 trajectories variations	cantharidin catalytic communities date desired fluorescent greatly libraries microcystin okadaic optimization pharmaceutical phosphatase phosphatases pp1 pp1alpha pp1calpha ppp1c representative robust screen selectively share simultaneously threonine z
Tagcloud (Intersection) ?