SH2D1A and CD84

Number of citations of the paper that reports this interaction (PMID 12928397)
12

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SH2D1A	CD84
Gene Name		SH2 domain containing 1A	CD84 molecule
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Receptor Activity Protein Binding
	Biological Process	Humoral Immune Response Cellular Defense Response Cell-cell Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	Defense Response Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Blood Coagulation Leukocyte Migration
Pathways			Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS			Response to anti-TNF treatment in rheumatoid arthritis ( 23555300)
Protein-Protein Interactions		19 interactors: ARHGEF6 ARHGEF7 CD84 DOK1 EGFR ERBB3 FYB FYN GRB2 LCK LHX4 LY9 MAPK1 MAPK11 MAPK14 SLAMF1 SLAMF6 SLAMF7 TNK2	2 interactors: SH2D1A SH2D1B
Entrez ID		4068	8832
HPRD ID		02390	05151
Ensembl ID		ENSG00000183918	ENSG00000066294
Uniprot IDs		O60880	Q9UIB8
PDB IDs		1D1Z 1D4T 1D4W 1KA6 1KA7 1M27	2PKD
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Immune System Process Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Intracellular Signal Transduction Innate Immune Response Immune Response Defense Response Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Immune Response Locomotion Response To Fibroblast Growth Factor Immune Response-regulating Cell Surface Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Fc-epsilon Receptor Signaling Pathway Cellular Response To Organic Substance Cell Activation Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Protein Phosphorylation Wound Healing Chemotaxis Response To Stimulus Phosphorylation Positive Regulation Of Immune Response Platelet Activation Response To Organic Substance Axon Guidance Response To Wounding Blood Coagulation Ras Protein Signal Transduction Hemostasis Positive Regulation Of Protein Phosphorylation MAPK Cascade Response To Stress Signal Transduction Cellular Response To Organonitrogen Compound Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Peptide	Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Cytotoxicity Immune Response Regulation Of Immune System Process Cellular Defense Response Positive Regulation Of Leukocyte Mediated Cytotoxicity Immune System Process Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Leukocyte Activation Involved In Immune Response Humoral Immune Response
Tagcloud ?		abl1 abl2 arrays bcar3 btk crk domains elisas exquisite fabricated fyn grap2 identity lck lyn monospecific nck1 phage pik3r1 plcgamma1 ptpn11 rasa1 resultant selections shc1 syk vav1 zap70
Tagcloud (Difference) ?		abl1 abl2 arrays bcar3 btk crk domains elisas exquisite fabricated fyn grap2 identity lck lyn monospecific nck1 phage pik3r1 plcgamma1 ptpn11 rasa1 resultant selections shc1 syk vav1 zap70
Tagcloud (Intersection) ?