SH2D1A and DOK1

Number of citations of the paper that reports this interaction (PMID 10852966)
8

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		SH2D1A	DOK1
Gene Name		SH2 domain containing 1A	docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Receptor Signaling Protein Activity Insulin Receptor Binding Protein Binding
	Biological Process	Humoral Immune Response Cellular Defense Response Cell-cell Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Insulin Receptor Signaling Pathway
Pathways			IRS-related events triggered by IGF1R Insulin receptor signalling cascade IRS activation IRS-mediated signalling Signal attenuation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events IGF1R signaling cascade PI3K Cascade PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: ARHGEF6 ARHGEF7 CD84 DOK1 EGFR ERBB3 FYB FYN GRB2 LCK LHX4 LY9 MAPK1 MAPK11 MAPK14 SLAMF1 SLAMF6 SLAMF7 TNK2	39 interactors: ABL1 ABL2 BCR CRK CRKL CSK ERBB2 FES FGR FYN GRB10 HCK INPP5D INSR ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 ITK KIT LCK LYN MAP4K4 NCK1 NCK2 PIK3R1 PLCG1 PTK6 PTPN6 PTPRH RASA1 RET SH2D1A SHC1 SRC TEC VAV1 YES1
Entrez ID		4068	1796
HPRD ID		02390	04228
Ensembl ID		ENSG00000183918	ENSG00000115325
Uniprot IDs		O60880	B3KP83 B4DJN1 Q2TA81 Q99704
PDB IDs		1D1Z 1D4T 1D4W 1KA6 1KA7 1M27	2V76
Enriched GO Terms of Interacting Partners?		Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Immune System Process Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Intracellular Signal Transduction Innate Immune Response Immune Response Defense Response Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Immune Response Locomotion Response To Fibroblast Growth Factor Immune Response-regulating Cell Surface Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Fc-epsilon Receptor Signaling Pathway Cellular Response To Organic Substance Cell Activation Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Protein Phosphorylation Wound Healing Chemotaxis Response To Stimulus Phosphorylation Positive Regulation Of Immune Response Platelet Activation Response To Organic Substance Axon Guidance Response To Wounding Blood Coagulation Ras Protein Signal Transduction Hemostasis Positive Regulation Of Protein Phosphorylation MAPK Cascade Response To Stress Signal Transduction Cellular Response To Organonitrogen Compound Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Peptide	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Autophosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Locomotion Cell Migration Immune System Process Cell Surface Receptor Signaling Pathway Cell Motility Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Protein Autophosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune System Process Leukocyte Migration Innate Immune Response Fc Receptor Signaling Pathway Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Communication Signal Transduction Immune Response Defense Response Wound Healing Blood Coagulation Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Hemostasis Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation ERBB Signaling Pathway Response To Wounding Cellular Response To Stimulus Single Organismal Cell-cell Adhesion Cellular Response To Organic Substance Peptidyl-amino Acid Modification Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Cell Activation Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Cell Activation Regulation Of Body Fluid Levels Chemotaxis Regulation Of Cell Adhesion Response To Stimulus Antigen Receptor-mediated Signaling Pathway Regulation Of Signaling
Tagcloud ?		abl1 abl2 arrays bcar3 btk crk domains elisas exquisite fabricated fyn grap2 identity lck lyn monospecific nck1 phage pik3r1 plcgamma1 ptpn11 rasa1 resultant selections shc1 syk vav1 zap70	adaptors coimmunoprecipitated comprises epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 stam2 transducing ut7epo validating
Tagcloud (Difference) ?		abl1 abl2 arrays bcar3 btk crk domains elisas exquisite fabricated fyn grap2 identity lck lyn monospecific nck1 phage pik3r1 plcgamma1 ptpn11 rasa1 resultant selections syk vav1 zap70	adaptors coimmunoprecipitated comprises epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a sprouty spry1 spry2 stam2 transducing ut7epo validating
Tagcloud (Intersection) ?		shc1