LMNA and ALOX12B

Number of citations of the paper that reports this interaction (PMID 10727209)
7

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		LMNA	ALOX12B
Gene Name		lamin A/C	arachidonate 12-lipoxygenase, 12R type
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Lamin Filament Nuclear Lamina Nucleoplasm Cytoplasm Cytosol Intermediate Filament Nuclear Speck Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function	Structural Molecule Activity Protein Binding	Arachidonate 12-lipoxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Linoleate 9S-lipoxygenase Activity
	Biological Process	Mitotic Cell Cycle Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Mitotic Nuclear Envelope Disassembly Mitotic Nuclear Envelope Reassembly Muscle Organ Development Regulation Of Cell Migration Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Endoplasmic Reticulum Unfolded Protein Response Protein Localization To Nucleus Sterol Regulatory Element Binding Protein Import Into Nucleus Cellular Protein Metabolic Process Ventricular Cardiac Muscle Cell Development Cellular Response To Hypoxia Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Cell Aging Regulation Of Protein Localization To Nucleus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Lipidation Sphingolipid Metabolic Process Positive Regulation Of Gene Expression Arachidonic Acid Metabolic Process Lipoxygenase Pathway Positive Regulation Of MAPK Cascade Linoleic Acid Metabolic Process Small Molecule Metabolic Process Ceramide Biosynthetic Process Hepoxilin Biosynthetic Process Oxidation-reduction Process Establishment Of Skin Barrier Positive Regulation Of Mucus Secretion
Pathways		IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)	Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of 12-eicosatetraenoic acid derivatives
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: ACTB ALOX12 ALOX12B CASP1 CASP6 CDK1 DBNL DUSP13 EGF EMD FLNA FOS GZMA GZMB KAT5 KRTAP10-3 KRTAP10-7 LMNB1 MLIP MRPS26 NARF PCBP1 PCGF2 PRKCA RB1 RBBP4 SH3KBP1 SMAD3 SREBF1 STAC SUMO4 SVIL SYNE1 TMPO TOR1A TOR1AIP1 UBE2I UCHL5 UNC13D URB2 VAV1 YWHAQ ZNF239	2 interactors: KRT5 LMNA
Entrez ID		4000	242
HPRD ID		01035	04772
Ensembl ID		ENSG00000160789	ENSG00000179477
Uniprot IDs		P02545	O75342
PDB IDs		1IFR 1IVT 1X8Y 2XV5 2YPT 3GEF 3V4Q 3V4W 3V5B
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Protein Localization Regulation Of Cellular Localization Positive Regulation Of Transport Nucleus Organization Nuclear Envelope Organization Regulation Of Signaling Regulation Of Establishment Of Protein Localization Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Regulation Of Signal Transduction Organelle Organization Positive Regulation Of Nucleocytoplasmic Transport Enzyme Linked Receptor Protein Signaling Pathway Response To Stress Cellular Response To Growth Factor Stimulus Positive Regulation Of Signal Transduction Response To Growth Factor Immune Response Cellular Response To Organic Substance Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Transport Regulation Of Catenin Import Into Nucleus Epidermal Growth Factor Receptor Signaling Pathway Execution Phase Of Apoptosis ERBB Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Protein Import Into Nucleus Positive Regulation Of Cellular Protein Metabolic Process Organ Development Cellular Response To Stimulus Response To Wounding Platelet Activation Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Transport Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Anatomical Structure Development Regulation Of Nucleocytoplasmic Transport Immune System Process Nuclear Membrane Organization Mitotic Nuclear Envelope Disassembly Intracellular Signal Transduction Positive Regulation Of Protein Localization To Nucleus Hepoxilin Metabolic Process Hepoxilin Biosynthetic Process	Sterol Regulatory Element Binding Protein Import Into Nucleus Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Positive Regulation Of Cell Aging Mitotic Nuclear Envelope Reassembly Nuclear Envelope Reassembly Hemidesmosome Assembly SREBP Signaling Pathway Response To Sterol Depletion Negative Regulation Of Release Of Cytochrome C From Mitochondria Ventricular Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Differentiation Negative Regulation Of Mitochondrion Organization Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Cell-substrate Junction Assembly Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Tissue Development Nuclear Envelope Organization Cardiac Muscle Cell Development Execution Phase Of Apoptosis Endoplasmic Reticulum Unfolded Protein Response Regulation Of Mitochondrion Organization Cellular Response To Hypoxia Cellular Response To Unfolded Protein Cellular Response To Decreased Oxygen Levels ER-nucleus Signaling Pathway Cellular Response To Oxygen Levels Cellular Response To Topologically Incorrect Protein Cardiac Muscle Cell Differentiation Protein Import Into Nucleus Nucleus Organization Nuclear Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Unfolded Protein Cardiocyte Differentiation
Tagcloud ?		1824c acro affiliated alopecia bossing chin clavicles contracture extremities g608g gilford groove hgps horse huazhong hutchinson joints micrognathia midline osteolysis phalanges progeria radiographical riding sclerodermatous stance stature tongji x10
Tagcloud (Difference) ?		1824c acro affiliated alopecia bossing chin clavicles contracture extremities g608g gilford groove hgps horse huazhong hutchinson joints micrognathia midline osteolysis phalanges progeria radiographical riding sclerodermatous stance stature tongji x10
Tagcloud (Intersection) ?