LMNA

Gene Name		lamin A/C
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Lamin Filament Nuclear Lamina Nucleoplasm Cytoplasm Cytosol Intermediate Filament Nuclear Speck Perinuclear Region Of Cytoplasm
	Molecular Function	Structural Molecule Activity Protein Binding
	Biological Process	Mitotic Cell Cycle Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Mitotic Nuclear Envelope Disassembly Mitotic Nuclear Envelope Reassembly Muscle Organ Development Regulation Of Cell Migration Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Endoplasmic Reticulum Unfolded Protein Response Protein Localization To Nucleus Sterol Regulatory Element Binding Protein Import Into Nucleus Cellular Protein Metabolic Process Ventricular Cardiac Muscle Cell Development Cellular Response To Hypoxia Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Cell Aging Regulation Of Protein Localization To Nucleus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-protein Interactions		43 interactors: ACTB ALOX12 ALOX12B CASP1 CASP6 CDK1 DBNL DUSP13 EGF EMD FLNA FOS GZMA GZMB KAT5 KRTAP10-3 KRTAP10-7 LMNB1 MLIP MRPS26 NARF PCBP1 PCGF2 PRKCA RB1 RBBP4 SH3KBP1 SMAD3 SREBF1 STAC SUMO4 SVIL SYNE1 TMPO TOR1A TOR1AIP1 UBE2I UCHL5 UNC13D URB2 VAV1 YWHAQ ZNF239
Entrez ID		4000
HPRD ID		01035
Ensembl ID		ENSG00000160789
Uniprot IDs		P02545
PDB IDs		1IFR 1IVT 1X8Y 2XV5 2YPT 3GEF 3V4Q 3V4W 3V5B
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Protein Localization Regulation Of Cellular Localization Positive Regulation Of Transport Nucleus Organization Nuclear Envelope Organization Regulation Of Signaling Regulation Of Establishment Of Protein Localization Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Regulation Of Signal Transduction Organelle Organization Positive Regulation Of Nucleocytoplasmic Transport Enzyme Linked Receptor Protein Signaling Pathway Response To Stress Cellular Response To Growth Factor Stimulus Positive Regulation Of Signal Transduction Response To Growth Factor Immune Response Cellular Response To Organic Substance Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Transport Regulation Of Catenin Import Into Nucleus Epidermal Growth Factor Receptor Signaling Pathway Execution Phase Of Apoptosis ERBB Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Protein Import Into Nucleus Positive Regulation Of Cellular Protein Metabolic Process Organ Development Cellular Response To Stimulus Response To Wounding Platelet Activation Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Transport Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Anatomical Structure Development Regulation Of Nucleocytoplasmic Transport Immune System Process Nuclear Membrane Organization Mitotic Nuclear Envelope Disassembly Intracellular Signal Transduction Positive Regulation Of Protein Localization To Nucleus Hepoxilin Metabolic Process Hepoxilin Biosynthetic Process
Tagcloud ?		1824c acro affiliated alopecia bossing chin clavicles contracture extremities g608g gilford groove hgps horse huazhong hutchinson joints micrognathia midline osteolysis phalanges progeria radiographical riding sclerodermatous stance stature tongji x10