LGALS1 and MUC16

Number of citations of the paper that reports this interaction (PMID 12615972)
18

Data Source:
HPRD (in vitro, in vivo)

		LGALS1	MUC16
Gene Name		lectin, galactoside-binding, soluble, 1	mucin 16, cell surface associated
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Intracellular Nucleus Cytoplasm Cell Surface Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Space Golgi Lumen Plasma Membrane Integral Component Of Membrane Extrinsic Component Of Membrane Vesicle Extracellular Vesicular Exosome
	Molecular Function	Glycoprotein Binding Signal Transducer Activity Protein Binding Galactoside Binding Lactose Binding Protein Homodimerization Activity Laminin Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	Plasma Cell Differentiation Apoptotic Process Signal Transduction Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Neuron Projection Development T Cell Costimulation Multicellular Organismal Response To Stress Positive Regulation Of Erythrocyte Aggregation Response To Drug Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Myoblast Differentiation Response To Axon Injury Cellular Response To Glucose Stimulus Cellular Response To Organic Cyclic Compound	Protein O-linked Glycosylation Cell Adhesion O-glycan Processing Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			Post-translational protein modification Termination of O-glycan biosynthesis O-linked glycosylation of mucins O-linked glycosylation
Drugs
Diseases
GWAS		Fat distribution (HIV) ( 21897333)
Protein-Protein Interactions		14 interactors: CD2 CD4 CD7 CD8A CDC42 GEMIN4 HRAS ITGB1 LGALS3BP MUC16 PTPRC SPN USP4 VPREB1	3 interactors: LGALS1 MSLN UBC
Entrez ID		3956	94025
HPRD ID		01040	07548
Ensembl ID		ENSG00000100097	ENSG00000181143
Uniprot IDs		P09382	B3KY81 B5ME49 Q8WXI7
PDB IDs		1GZW 1W6M 1W6N 1W6O 1W6P 1W6Q 2KM2 2ZKN 3OY8 3OYW 3T2T
Enriched GO Terms of Interacting Partners?		Cell Adhesion Single Organismal Cell-cell Adhesion Leukocyte Cell-cell Adhesion Lymphocyte Activation Leukocyte Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Homotypic Cell-cell Adhesion Leukocyte Differentiation Cell Activation Regulation Of Immune System Process Leukocyte Migration Defense Response Regulation Of Immune Response Lymphocyte Differentiation Heterotypic Cell-cell Adhesion Immune System Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell Adhesion Hemopoiesis Immune System Development Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Phosphorylation Regulation Of Cell-cell Adhesion T Cell Differentiation Regulation Of Lymphocyte Activation Locomotion T Cell Selection Blood Coagulation Positive Regulation Of Intracellular Signal Transduction Hemostasis Cell Migration Positive Regulation Of Phosphorylation Cellular Defense Response Regulation Of Cell Activation Visual Learning Positive Regulation Of T Cell Activation Cell Motility Positive Regulation Of Protein Modification Process Visual Behavior Positive Regulation Of Homotypic Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion T Cell Costimulation Regulation Of Body Fluid Levels Associative Learning Regulation Of Protein Phosphorylation	Positive Regulation Of Erythrocyte Aggregation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Plasma Cell Differentiation Viral Protein Processing Mature B Cell Differentiation Involved In Immune Response Mature B Cell Differentiation Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Apoptotic Process Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Programmed Cell Death Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Myoblast Differentiation Cell Death Death Negative Regulation Of ERBB Signaling Pathway B Cell Activation Involved In Immune Response Negative Regulation Of Cell-substrate Adhesion Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 9 Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Cellular Response To Glucose Stimulus Glycogen Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway
Tagcloud ?		abundance adenocarcinomas aversely clues die dismal ductal extend galectin lethal pancreas pancreatic pdac personalized prelp prolargin proteome proteomes rarely rps8 s8 sts survive survivors tgfbeta top upstream vegfa vlts	altering arhi atlas belong brca1 ca125 clarified cnvs consequences copy diras3 dysregulated emphasis he4 imprinted messenger micrornas mirna mirnas mirs ovarian profiling projects remarkable rnas summarizes tcga variations wfdc2
Tagcloud (Difference) ?		abundance adenocarcinomas aversely clues die dismal ductal extend galectin lethal pancreas pancreatic pdac personalized prelp prolargin proteome proteomes rarely rps8 s8 sts survive survivors tgfbeta top upstream vegfa vlts	altering arhi atlas belong brca1 ca125 clarified cnvs consequences copy diras3 dysregulated emphasis he4 imprinted messenger micrornas mirna mirnas mirs ovarian profiling projects remarkable rnas summarizes tcga variations wfdc2
Tagcloud (Intersection) ?