LGALS1 and USP4

Number of citations of the paper that reports this interaction (PMID 23022198)
1

Data Source:
BioGRID (two hybrid)

		LGALS1	USP4
Gene Name		lectin, galactoside-binding, soluble, 1	ubiquitin specific peptidase 4 (proto-oncogene)
Image
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Intracellular Nucleus Cytoplasm Cell Surface Extracellular Matrix Extracellular Vesicular Exosome	Nucleus Cytoplasm Lysosome Plasma Membrane
	Molecular Function	Glycoprotein Binding Signal Transducer Activity Protein Binding Galactoside Binding Lactose Binding Protein Homodimerization Activity Laminin Binding Poly(A) RNA Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Adenosine Receptor Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Plasma Cell Differentiation Apoptotic Process Signal Transduction Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Neuron Projection Development T Cell Costimulation Multicellular Organismal Response To Stress Positive Regulation Of Erythrocyte Aggregation Response To Drug Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Myoblast Differentiation Response To Axon Injury Cellular Response To Glucose Stimulus Cellular Response To Organic Cyclic Compound	Spliceosomal Tri-snRNP Complex Assembly Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Cell Surface Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Fat distribution (HIV) ( 21897333)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		14 interactors: CD2 CD4 CD7 CD8A CDC42 GEMIN4 HRAS ITGB1 LGALS3BP MUC16 PTPRC SPN USP4 VPREB1	46 interactors: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BRAP CDKN1A FAM96B HUWE1 IGKV2D-29 LAMA5 LGALS1 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBL1 RBL2 RCC1 SART3 SMN1 TCF4 TGFBR1 TK1 TP53BP2 TRAF2 TRAF6 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28
Entrez ID		3956	7375
HPRD ID		01040	04598
Ensembl ID		ENSG00000100097	ENSG00000114316
Uniprot IDs		P09382	Q08AK7 Q13107
PDB IDs		1GZW 1W6M 1W6N 1W6O 1W6P 1W6Q 2KM2 2ZKN 3OY8 3OYW 3T2T	2Y6E
Enriched GO Terms of Interacting Partners?		Cell Adhesion Single Organismal Cell-cell Adhesion Leukocyte Cell-cell Adhesion Lymphocyte Activation Leukocyte Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Homotypic Cell-cell Adhesion Leukocyte Differentiation Cell Activation Regulation Of Immune System Process Leukocyte Migration Defense Response Regulation Of Immune Response Lymphocyte Differentiation Heterotypic Cell-cell Adhesion Immune System Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell Adhesion Hemopoiesis Immune System Development Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Phosphorylation Regulation Of Cell-cell Adhesion T Cell Differentiation Regulation Of Lymphocyte Activation Locomotion T Cell Selection Blood Coagulation Positive Regulation Of Intracellular Signal Transduction Hemostasis Cell Migration Positive Regulation Of Phosphorylation Cellular Defense Response Regulation Of Cell Activation Visual Learning Positive Regulation Of T Cell Activation Cell Motility Positive Regulation Of Protein Modification Process Visual Behavior Positive Regulation Of Homotypic Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion T Cell Costimulation Regulation Of Body Fluid Levels Associative Learning Regulation Of Protein Phosphorylation	G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Apoptotic Process Cell Cycle Response To Stress Programmed Cell Death Cell Death Death Response To Stimulus Protein Polyubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle Protein Ubiquitination Mitotic Cell Cycle Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Immune System Process Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Cell Cycle Process Regulation Of Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Proteolysis Regulation Of Lipid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Transferase Activity Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Catalytic Activity Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Intracellular Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cell Cycle Checkpoint Cellular Response To Stimulus Mitotic G1 DNA Damage Checkpoint Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		abundance adenocarcinomas aversely clues die dismal ductal extend galectin lethal pancreas pancreatic pdac personalized prelp prolargin proteome proteomes rarely rps8 s8 sts survive survivors tgfbeta top upstream vegfa vlts	1beta adaptor associates deubiquitinase deubiquitinates deubiquitination ectopic ikappabalpha importantly incompletely insight interact interacts kappab kappabalpha negatively nf polyubiquitination protease reporter signalling tnfalpha traf traf2 traf3 traf6 ubiquitin uncovers
Tagcloud (Difference) ?		abundance adenocarcinomas aversely clues die dismal ductal extend galectin lethal pancreas pancreatic pdac personalized prelp prolargin proteome proteomes rarely rps8 s8 sts survive survivors tgfbeta top upstream vegfa vlts	1beta adaptor associates deubiquitinase deubiquitinates deubiquitination ectopic ikappabalpha importantly incompletely insight interact interacts kappab kappabalpha negatively nf polyubiquitination protease reporter signalling tnfalpha traf traf2 traf3 traf6 ubiquitin uncovers
Tagcloud (Intersection) ?