RPSA and LAMA2

Number of citations of the paper that reports this interaction (PMID 11054877)
51

Data Source:
HPRD (in vitro)

		RPSA	LAMA2
Gene Name		ribosomal protein SA	laminin, alpha 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cytosolic Small Ribosomal Subunit 90S Preribosome Extracellular Vesicular Exosome	Extracellular Region Basement Membrane Laminin-1 Complex Extracellular Matrix Sarcolemma Dendritic Spine Extracellular Vesicular Exosome
	Molecular Function	Structural Constituent Of Ribosome Laminin Receptor Activity Protein Binding Ribosome Binding Laminin Binding Poly(A) RNA Binding	Receptor Binding Structural Molecule Activity
	Biological Process	Ribosomal Small Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Export From Nucleus Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Cell Adhesion Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process	Cell Adhesion Axon Guidance Muscle Organ Development Myelination In Peripheral Nervous System Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Embryonic Development
Pathways		Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Laminin interactions ECM proteoglycans Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS			Body mass index ( 20397748) Refractive error ( 23396134)
Protein-Protein Interactions		27 interactors: ABCD1 ACADVL ACD ANKH C6orf106 CALM2 CBX5 CLEC4G CSF2RA DCTN6 GNMT HBG2 HNRNPD IL7R ITGA6 KARS LAMA2 NKX3-1 POT1 PRND PROS1 RNF114 RPS21 SLC2A5 SUMO4 TINF2 TRIB3	2 interactors: DAG1 RPSA
Entrez ID		3921	3908
HPRD ID		01038	01125
Ensembl ID		ENSG00000168028	ENSG00000196569
Uniprot IDs		P08865	P24043 Q59H37
PDB IDs		3BCH 3J3A
Enriched GO Terms of Interacting Partners?		Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Protein Localization To Chromosome, Telomeric Region Telomere Capping Negative Regulation Of DNA Replication Positive Regulation Of Telomerase Activity Positive Regulation Of Transferase Activity Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Fatty Acid Biosynthetic Process Blood Coagulation Hemostasis Negative Regulation Of Chromosome Organization Regulation Of Telomerase Activity Negative Regulation Of DNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Fatty Acid Metabolic Process Regulation Of Body Fluid Levels Regulation Of DNA Replication Wound Healing Negative Regulation Of Biosynthetic Process Protein Localization To Chromosome Positive Regulation Of DNA Metabolic Process Cellular Response To Organic Substance Telomere Maintenance Via Telomere Lengthening Regulation Of Fatty Acid Biosynthetic Process Response To Wounding Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of Protein ADP-ribosylation Lysyl-tRNA Aminoacylation Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Peroxisomal Long-chain Fatty Acid Import Fructose Transport Regulation Of DNA Biosynthetic Process Fatty Acid Beta-oxidation Regulation Of Chromosome Organization Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Metabolic Process Glycogen Metabolic Process Response To Stress Regulation Of Protein ADP-ribosylation Inorganic Diphosphate Transport Positive Regulation Of Androgen Secretion Interleukin-7-mediated Signaling Pathway	Viral Life Cycle Nerve Maturation Nucleocytoplasmic Transport Nuclear Transport Calcium-dependent Cell-matrix Adhesion RRNA Export From Nucleus Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Establishment Of Protein Localization To Organelle Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Protein Targeting RRNA Transport RRNA 3'-end Processing Protein Localization To Organelle Viral Process Commissural Neuron Axon Guidance Cytoplasmic Transport Ribosomal Small Subunit Assembly Cytoskeletal Anchoring At Plasma Membrane Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Basement Membrane Organization Maturation Of 5.8S RRNA Intracellular Protein Transport Membrane Protein Ectodomain Proteolysis NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Morphology Or Physiology Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Branching Involved In Salivary Gland Morphogenesis Ribosome Assembly Maturation Of SSU-rRNA Cell Adhesion Membrane Protein Proteolysis Negative Regulation Of Protein Kinase B Signaling Cellular Protein Localization Ribosomal Small Subunit Biogenesis Salivary Gland Morphogenesis Viral Entry Into Host Cell Myelination In Peripheral Nervous System Salivary Gland Development Epithelial Tube Branching Involved In Lung Morphogenesis Protein Transport Entry Into Host Cell Schwann Cell Development Establishment Of Protein Localization Intracellular Transport Exocrine System Development Morphogenesis Of An Epithelial Sheet Microtubule Anchoring Schwann Cell Differentiation Lung Morphogenesis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Tagcloud ?		abolish arg357 bonds confer conformational crystal elusive exhibits exquisite hydrogen hydrophobic insights lys303 mode mtb phe307 phe310 poa pyrazinamide pyrazinoic pza questions reveals ribosomal s1 shortening tb terminus tmrna	activlim ambulatory cmd cmds col6 dystrophy egen extremities fvc goniometry hammersmith hfms klassification meter mfm32 muscular myometry neuromuscular nsaa pedsql promis quest rater rd reliabilities sitting star timed walk
Tagcloud (Difference) ?		abolish arg357 bonds confer conformational crystal elusive exhibits exquisite hydrogen hydrophobic insights lys303 mode mtb phe307 phe310 poa pyrazinamide pyrazinoic pza questions reveals ribosomal s1 shortening tb terminus tmrna	activlim ambulatory cmd cmds col6 dystrophy egen extremities fvc goniometry hammersmith hfms klassification meter mfm32 muscular myometry neuromuscular nsaa pedsql promis quest rater rd reliabilities sitting star timed walk
Tagcloud (Intersection) ?