RPSA and IL7R

Number of citations of the paper that reports this interaction (PMID 23151878)
3

Data Source:
BioGRID (unspecified method)

		RPSA	IL7R
Gene Name		ribosomal protein SA	interleukin 7 receptor
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cytosolic Small Ribosomal Subunit 90S Preribosome Extracellular Vesicular Exosome	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Structural Constituent Of Ribosome Laminin Receptor Activity Protein Binding Ribosome Binding Laminin Binding Poly(A) RNA Binding	Antigen Binding Interleukin-7 Receptor Activity Protein Binding
	Biological Process	Ribosomal Small Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Export From Nucleus Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Cell Adhesion Gene Expression Viral Process Viral Life Cycle Viral Transcription Cellular Protein Metabolic Process	Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immunoglobulin Production Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Size Positive Regulation Of Gene Expression Cell Growth T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells
Pathways		Nonsense-Mediated Decay (NMD) Translation initiation complex formation Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition Formation of the ternary complex, and subsequently, the 43S complex Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Signaling by Interleukins Interleukin-7 signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			Multiple sclerosis ( 21244703 19525953 21833088) Primary biliary cirrhosis ( 23000144 21399635) Type 1 diabetes ( 17554260) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		27 interactors: ABCD1 ACADVL ACD ANKH C6orf106 CALM2 CBX5 CLEC4G CSF2RA DCTN6 GNMT HBG2 HNRNPD IL7R ITGA6 KARS LAMA2 NKX3-1 POT1 PRND PROS1 RNF114 RPS21 SLC2A5 SUMO4 TINF2 TRIB3	104 interactors: ALYREF CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 GNB2L1 H1FX HIST1H1C HIST1H1E HIST2H2BE HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MAP4 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787
Entrez ID		3921	3575
HPRD ID		01038	00893
Ensembl ID		ENSG00000168028	ENSG00000168685
Uniprot IDs		P08865	D6RGV2 D9N160 P16871
PDB IDs		3BCH 3J3A	3DI2 3DI3 3UP1
Enriched GO Terms of Interacting Partners?		Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Protein Localization To Chromosome, Telomeric Region Telomere Capping Negative Regulation Of DNA Replication Positive Regulation Of Telomerase Activity Positive Regulation Of Transferase Activity Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Fatty Acid Biosynthetic Process Blood Coagulation Hemostasis Negative Regulation Of Chromosome Organization Regulation Of Telomerase Activity Negative Regulation Of DNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of Fatty Acid Metabolic Process Regulation Of Body Fluid Levels Regulation Of DNA Replication Wound Healing Negative Regulation Of Biosynthetic Process Protein Localization To Chromosome Positive Regulation Of DNA Metabolic Process Cellular Response To Organic Substance Telomere Maintenance Via Telomere Lengthening Regulation Of Fatty Acid Biosynthetic Process Response To Wounding Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of Protein ADP-ribosylation Lysyl-tRNA Aminoacylation Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Peroxisomal Long-chain Fatty Acid Import Fructose Transport Regulation Of DNA Biosynthetic Process Fatty Acid Beta-oxidation Regulation Of Chromosome Organization Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Metabolic Process Glycogen Metabolic Process Response To Stress Regulation Of Protein ADP-ribosylation Inorganic Diphosphate Transport Positive Regulation Of Androgen Secretion Interleukin-7-mediated Signaling Pathway	MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing RNA Splicing MRNA Processing RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Viral Process RNA Biosynthetic Process SRP-dependent Cotranslational Protein Targeting To Membrane Termination Of RNA Polymerase II Transcription Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of RNA Stability Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein Localization To Endoplasmic Reticulum Viral Life Cycle Cytoplasmic Transport Posttranscriptional Regulation Of Gene Expression MRNA Stabilization RNA 3'-end Processing MRNA 3'-end Processing RNA Catabolic Process Viral Transcription Cellular Metabolic Process Protein Targeting To Membrane DNA-templated Transcription, Termination Protein Targeting Nuclear-transcribed MRNA Catabolic Process Establishment Of Protein Localization To Organelle MRNA Catabolic Process Ribonucleoprotein Complex Assembly Regulation Of Translation Ribonucleoprotein Complex Biogenesis Biosynthetic Process Protein Localization To Organelle Translational Termination Establishment Of Protein Localization To Membrane Intracellular Transport Translational Elongation
Tagcloud ?		abolish arg357 bonds confer conformational crystal elusive exhibits exquisite hydrogen hydrophobic insights lys303 mode mtb phe307 phe310 poa pyrazinamide pyrazinoic pza questions reveals ribosomal s1 shortening tb terminus tmrna	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		abolish arg357 bonds confer conformational crystal elusive exhibits exquisite hydrogen hydrophobic insights lys303 mode mtb phe307 phe310 poa pyrazinamide pyrazinoic pza questions reveals ribosomal s1 shortening tb terminus tmrna	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?