ARHGAP1 and BNIPL

Number of citations of the paper that reports this interaction (PMID 12901880)
4

Data Source:
HPRD (in vitro, two hybrid)

		ARHGAP1	BNIPL
Gene Name		Rho GTPase activating protein 1	BCL2/adenovirus E1B 19kD interacting protein like
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytosol Plasma Membrane Extracellular Vesicular Exosome	Nucleus Cytosol
	Molecular Function	SH3/SH2 Adaptor Activity Rho GTPase Activator Activity Protein Binding SH3 Domain Binding Rac GTPase Activator Activity	Protein Binding Identical Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Rac GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Apoptotic Process Negative Regulation Of Cell Proliferation Regulation Of Growth Rate
Pathways		Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Bone mineral density (hip) ( 19801982)	Chronic kidney disease ( 20383146)
Protein-Protein Interactions		21 interactors: BAI2 BNIP2 BNIPL CDC42 CHEK2 EPB41L1 HMGCR HSP90AB1 ITPR1 KIF1B PIK3R1 PTPN11 RAC1 RASA1 RHOA RHOC SMARCD3 SRC TAX1BP1 TUBA4A WAS	14 interactors: ARHGAP1 BAX BCL2 BCL2L1 BNIP2 CDC42 FKBP8 GFER MIF NME2 PXDN PYCR1 RECQL5 SNAPIN
Entrez ID		392	149428
HPRD ID		04108	16557
Ensembl ID		ENSG00000175220	ENSG00000163141
Uniprot IDs		Q07960	Q7Z465
PDB IDs		1AM4 1GRN 1OW3 1RGP 1TX4 2NGR
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Wound Healing Blood Coagulation Fc Receptor Signaling Pathway Hemostasis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Wounding Ephrin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Axon Guidance Phagocytosis Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway T Cell Costimulation Axonogenesis Movement Of Cell Or Subcellular Component Innate Immune Response Platelet Activation Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neurotrophin TRK Receptor Signaling Pathway Chemotaxis Neurotrophin Signaling Pathway Regulation Of Protein Transport Neuron Projection Morphogenesis Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Phosphatidylinositol 3-kinase Activity Programmed Cell Death Cell Morphogenesis Involved In Differentiation Cell Death Death Regulation Of Lipid Kinase Activity Regulation Of Protein Localization Cytoskeleton Organization Positive Regulation Of Intracellular Signal Transduction Neuron Projection Development Generation Of Neurons Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Projection Morphogenesis Developmental Process Cell Part Morphogenesis Regulation Of Immune Response Neurogenesis Locomotion	Regulation Of Mitochondrial Membrane Potential Regulation Of Protein Heterodimerization Activity Negative Regulation Of Cell Death Regulation Of Cell Death Ovarian Follicle Development Positive Regulation Of Signal Transduction Ovulation Cycle Process Negative Regulation Of Apoptotic Process Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Programmed Cell Death Female Gonad Development Regulation Of Apoptotic Process Ovulation Cycle Development Of Primary Female Sexual Characteristics Release Of Cytochrome C From Mitochondria Regulation Of Nitrogen Utilization Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Protein Binding Mitochondrial Transport Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Gamma Radiation Male Sex Differentiation Positive Regulation Of Intracellular Signal Transduction Neuron Apoptotic Process Regulation Of Signal Transduction Regulation Of Cell Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Neuron Death Positive Regulation Of Cell Development Gonad Development Apoptotic Mitochondrial Changes Development Of Primary Sexual Characteristics Regulation Of Neuron Apoptotic Process Positive Regulation Of Intracellular Transport Germ Cell Development Regulation Of Signaling Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Binding Regulation Of Cellular Localization Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Membrane Potential Positive Regulation Of Muscle Cell Differentiation Regulation Of Neuron Death Negative Regulation Of Signal Transduction Sex Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Tagcloud ?		al7a1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus f2rl2 fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1	allowing alters antagonization antagonize antiapoptotic bag1 bcl bcl2l13 becn1 bmf bnip1 bnip3 clu conditional considering erbb2 influences influencing master mcl members proapoptotic prognosis prototypic relevance remission substitute tegt whereby
Tagcloud (Difference) ?		al7a1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus f2rl2 fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1	allowing alters antagonization antagonize antiapoptotic bag1 bcl bcl2l13 becn1 bmf bnip1 bnip3 clu conditional considering erbb2 influences influencing master mcl members proapoptotic prognosis prototypic relevance remission substitute tegt whereby
Tagcloud (Intersection) ?