RHOC and DIAPH1

Number of citations of the paper that reports this interaction (PMID 15864301)
70

Data Source:
HPRD (in vitro)

		RHOC	DIAPH1
Gene Name		ras homolog family member C	diaphanous-related formin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Cleavage Furrow Extracellular Vesicular Exosome	Cytoplasm Ruffle Membrane Neuron Projection Mitotic Spindle
	Molecular Function	Signal Transducer Activity Protein Binding GTP Binding	Actin Binding Receptor Binding Protein Binding Profilin Binding Rho GTPase Binding Identical Protein Binding Ion Channel Binding Poly(A) RNA Binding
	Biological Process	Cytokinesis Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apical Junction Assembly Wound Healing, Spreading Of Cells Regulation Of Small GTPase Mediated Signal Transduction Skeletal Muscle Satellite Cell Migration	Cytoskeleton Organization Sensory Perception Of Sound Regulation Of Cell Shape Actin Filament Polymerization Positive Regulation Of Cell Migration Neuron Projection Development Regulation Of Microtubule-based Process Protein Localization To Microtubule Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Histamine
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Axon guidance Semaphorin interactions Signaling by Rho GTPases G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ARHGAP1 CAV1 CIT DIAPH1 FAM65B ROCK1 RTKN	15 interactors: APBB1 BAIAP2 CDC7 CENPA GAS7 NEDD4 PAX6 PKD2 PRPF40A RAC1 RHOA RHOC TCERG1 WBP4 XPO6
Entrez ID		389	1729
HPRD ID		01322	03670
Ensembl ID		ENSG00000155366	ENSG00000131504
Uniprot IDs		P08134	O60610 Q6URC4
PDB IDs		1Z2C 2GCN 2GCO 2GCP
Enriched GO Terms of Interacting Partners?		Rho Protein Signal Transduction Ras Protein Signal Transduction Intracellular Signal Transduction Regulation Of Actin Filament-based Process Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Nitric Oxide Homeostasis Regulation Of Epithelial Cell Differentiation Regulation Of Cellular Component Movement Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Inward Rectifier Potassium Channel Activity Sensory Perception Of Sound Regulation Of Ion Homeostasis Cell Differentiation Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Pinocytosis Sensory Perception Of Mechanical Stimulus Regulation Of Cellular Component Organization Neuron Projection Development Regulation Of Calcium Ion Transport Caveolin-mediated Endocytosis Protein Localization To Basolateral Plasma Membrane Membrane To Membrane Docking Mammary Gland Involution Protein Localization To Plasma Membrane Raft Apical Constriction Leukocyte Migration Positive Regulation Of Metalloenzyme Activity Caveola Assembly Neuron Development Apoptotic Process Regulation Of Cardiac Muscle Cell Action Potential Regulation Of The Force Of Heart Contraction By Chemical Signal Protein Localization To Microtubule Programmed Cell Death Metaphase/anaphase Transition Of Mitotic Cell Cycle Negative Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Dendrite Morphogenesis Cellular Response To Stimulus System Development Cell Death Death Cellular Response To Hyperoxia Cellular Response To Histamine Regulation Of Catalytic Activity Muscle Organ Development	Regulation Of Cell Morphogenesis Neuron Projection Development Cell Cycle Regulation Of Cellular Component Organization Neuron Development Neuron Projection Morphogenesis Cell Cycle Process Neuron Differentiation Cytoskeleton Organization Cell Projection Organization Cell Projection Morphogenesis Skeletal Muscle Satellite Cell Migration Cell Part Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Generation Of Neurons Cell Morphogenesis Positive Regulation Of DNA Metabolic Process Nervous System Development Regulation Of Cell Shape Neurogenesis Cell Morphogenesis Involved In Differentiation Axon Guidance Anatomical Structure Morphogenesis Cell Development Locomotion Cell Migration Cell Motility Regulation Of Cell Cycle Chemotaxis Organelle Organization Mitotic Cell Cycle Process Response To External Stimulus Response To Stress Mitotic Cell Cycle Protein Localization Cell Cycle Arrest Positive Regulation Of Intracellular Signal Transduction Cellular Protein Localization Cell Division Regulation Of Cell Development Microtubule Cytoskeleton Organization Movement Of Cell Or Subcellular Component Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Projection Organization Regulation Of Cell Cycle Process Negative Regulation Of Neuron Differentiation Wound Healing, Spreading Of Cells
Tagcloud ?		addiction belongs compromised cytoskeletal epilepsy glioblastoma glioma gtpase homologs inversely limiting nononcogene p21cip1 phenotypes retaining rhoa rhob scarcity spheroid stat3 trafficking tumorigenic v14 vast vesicle waf1 xenograft xenografts	5q 5q31 aberrantly abnormality autonomous cd14 del deregulated formin granulocytes hematologic heterozygosity heterozygous hypersensitive innate knockout lenalidomide lineages lipopolysaccharide mdia1 mdss mechanistically messenger mimicking neoplasm polymerization rescued toll underscore
Tagcloud (Difference) ?		addiction belongs compromised cytoskeletal epilepsy glioblastoma glioma gtpase homologs inversely limiting nononcogene p21cip1 phenotypes retaining rhoa rhob scarcity spheroid stat3 trafficking tumorigenic v14 vast vesicle waf1 xenograft xenografts	5q 5q31 aberrantly abnormality autonomous cd14 del deregulated formin granulocytes hematologic heterozygosity heterozygous hypersensitive innate knockout lenalidomide lineages lipopolysaccharide mdia1 mdss mechanistically messenger mimicking neoplasm polymerization rescued toll underscore
Tagcloud (Intersection) ?